Low potency inhibition of Na

Anesthetics, Local / pharmacology HEK293 Cells Humans Lidocaine / analogs & derivatives Sodium / metabolism Sodium Channel Blockers / pharmacology
Lidocaine Local anesthetic Na(V)1.7 Pain QX-314 Voltage-gated sodium channel

Journal

European journal of pharmacology
ISSN: 1879-0712
Titre abrégé: Eur J Pharmacol
Pays: Netherlands
ID NLM: 1254354

Informations de publication

Date de publication:
15 Jun 2022
Historique:
received: 26 08 2021
revised: 11 04 2022
accepted: 04 05 2022
pubmed: 11 5 2022
medline: 1 6 2022
entrez: 10 5 2022
Statut: ppublish

Résumé

QX-314 is a quaternary permanently charged lidocaine derivative that inhibits voltage-gated sodium channels (Na

Identifiants

DOI: 10.1016/j.ejphar.2022.175013 PMID: 35537491
pubmed: 35537491
pii: S0014-2999(22)00274-6
doi: 10.1016/j.ejphar.2022.175013
pii:
doi:

Substances chimiques

Anesthetics, Local 0
Sodium Channel Blockers 0
QX-314 21306-56-9
Lidocaine 98PI200987
Sodium 9NEZ333N27

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

175013

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Auteurs

Tabea Klasfauseweh (T)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia; Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.

Mathilde R Israel (MR)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia; Wolfson Centre for Age-Related Diseases, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE1 1UL, UK.

Lotten Ragnarsson (L)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia.

James J Cox (JJ)

Molecular Nociception Group, Wolfson Institute for Biomedical Research, University College London, London, WC1E 6BT, UK.

Thomas Durek (T)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia.

David A Carter (DA)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia.

Andreas Leffler (A)

Department of Anaesthesiology and Intensive Care Medicine, Hannover Medical School, 30625, Hannover, Germany.

Irina Vetter (I)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia; School of Pharmacy, The University of Queensland, Woolloongabba, QLD, 4102, Australia. Electronic address: i.vetter@uq.edu.au.

Jennifer R Deuis (JR)

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, QLD, 4072, Australia. Electronic address: j.deuis@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Dépresseurs du système nerveux central › Anesthésiques › Anesthésiques locaux › Low potency inhibition of Na
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Low potency inhibition of Na
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Low potency inhibition of Na
questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Anilides › Acétanilides › Lidocaïne › Low potency inhibition of Na
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Sodium › Low potency inhibition of Na
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Bloqueurs de canaux sodiques › Low potency inhibition of Na