Early SARS-CoV-2-associated acute transverse myelitis: A case for neurotropism?
COVID-19
SARS-COV-2
myelitis
neurotropism
Journal
Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
pubmed:
6
7
2022
medline:
21
9
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
There are increasing reports of immune-mediated and para-infectious syndromes beyond the well-known respiratory manifestations of severe-acute-respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the spectrum of severe neurological sequelae of SARS-CoV-2 remains undefined. We present the case of a 66-year-old female with rapidly progressive lower limb neurology 3 days post SARS-CoV-2 infection. Clinical and radiological findings were in keeping with transverse myelitis and treatment success was achieved with methylprednisolone and remdesivir. This report will discuss the associations between SARS-CoV-2 and acute transverse myelitis. We believe this is one of few described cases of early SARS-CoV-2-associated transverse myelitis secondary to neurotropism and the first successfully treated with the inclusion of remdesivir in the therapeutic regimen.
Identifiants
pubmed: 35781711
doi: 10.1111/joim.13542
pmc: PMC9350090
doi:
Substances chimiques
Methylprednisolone
X4W7ZR7023
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
679-683Informations de copyright
© 2022 The Association for the Publication of the Journal of Internal Medicine.
Références
Immun Inflamm Dis. 2021 Mar;9(1):48-58
pubmed: 33332737
J Intern Med. 2022 Oct;292(4):679-683
pubmed: 35781711
Adv Exp Med Biol. 2014;807:75-96
pubmed: 24619619
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
J Neurol Sci. 2021 Feb 15;421:117316
pubmed: 33561753
Front Immunol. 2021 Apr 26;12:653786
pubmed: 33981305
Semin Neurol. 2012 Apr;32(2):97-113
pubmed: 22961185
J Neurol. 2021 Sep;268(9):3059-3071
pubmed: 33486564
J Neurol. 2020 Jul;267(7):1880-1882
pubmed: 32361836
J Med Virol. 2020 Jun;92(6):552-555
pubmed: 32104915
N Engl J Med. 2022 Jan 27;386(4):305-315
pubmed: 34937145
ACS Chem Neurosci. 2020 Apr 1;11(7):995-998
pubmed: 32167747
Acta Neurol Scand. 2022 Jan;145(1):5-9
pubmed: 34750810
Radiol Case Rep. 2020 Jun 06;15(9):1591-1595
pubmed: 32685076