EGR2 Deletion Suppresses Anti-DsDNA Autoantibody and IL-17 Production in Autoimmune-Prone B6/lpr Mice: A Differential Immune Regulatory Role of EGR2 in B6/lpr Versus Normal B6 Mice.

Animals Antibodies, Antinuclear Autoantibodies Early Growth Response Protein 2 / genetics Immunoglobulin G Inflammation Interleukin-17 / biosynthesis Mice Mice, Inbred C57BL
EGR2 IL-17 anti-dsDNA autoantibody double negative T cell murine model plasma cell

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2022
Historique:
received: 11 04 2022
accepted: 20 05 2022
entrez: 5 7 2022
pubmed: 6 7 2022
medline: 7 7 2022
Statut: epublish

Résumé

Previous studies have reported that deletion of the transcription factor, early growth response protein 2 (EGR2), in normal C57BL/6 (B6) resulted in the development of lupus-like autoimmune disease. However, increased EGR2 expression has been noted in human and murine lupus, which challenges the notion of the autoimmune suppressive role of EGR2 in B6 mice. In this study, we derived both conditional EGR2

Identifiants

DOI: 10.3389/fimmu.2022.917866 PMID: 35784356 PMC: PMC9241489
pubmed: 35784356
doi: 10.3389/fimmu.2022.917866
pmc: PMC9241489
doi:

Substances chimiques

Antibodies, Antinuclear 0
Autoantibodies 0
Early Growth Response Protein 2 0
Egr2 protein, mouse 0
Il17a protein, mouse 0
Immunoglobulin G 0
Interleukin-17 0
anti-dsDNA autoantibody 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

917866

Informations de copyright

Copyright © 2022 Dai, Wang, Heid, Eden, Reilly and Ahmed.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Rujuan Dai (R)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.

Zhuang Wang (Z)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.

Bettina Heid (B)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.

Kristin Eden (K)

Department of Basic Science Education, Virginia Tech Carilion School of Medicine, Roanoke, VA, United States.

Christopher M Reilly (CM)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.
Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States.

S Ansar Ahmed (SA)

Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine (VMCVM), Virginia Tech, Blacksburg, VA, United States.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Anticorps antinucléaires › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription EGR › Facteur de transcription EGR-2 › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline G › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › EGR2 Deletion Suppresses Anti-DsDNA...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › EGR2 Deletion Suppresses Anti-DsDNA...