Modification of the Langendorff system of the isolated beating heart for experimental radiotherapy at a synchrotron: 4000 Gy in a heart beat.
Langendorff model of the isolated beating heart
microbeam irradiation (MBI)
organ of risk
Journal
Journal of synchrotron radiation
ISSN: 1600-5775
Titre abrégé: J Synchrotron Radiat
Pays: United States
ID NLM: 9888878
Informations de publication
Date de publication:
01 Jul 2022
01 Jul 2022
Historique:
received:
12
12
2021
accepted:
28
04
2022
entrez:
5
7
2022
pubmed:
6
7
2022
medline:
7
7
2022
Statut:
ppublish
Résumé
Microbeam radiotherapy could help to cure malignant tumours which are currently still considered therapy-resistant. With an irradiation target in the thoracic cavity, the heart would be one of the most important organs at risk. To assess the acute adverse effects of microbeam irradiation in the heart, a powerful ex vivo tool was created by combining the Langendorff model of the isolated beating mammalian heart with X-Tream dosimetry. In a first pilot experiment conducted at the Biomedical and Imaging Beamline of the Australian Synchrotron, the system was tested at a microbeam peak dose approximately ten times higher than the anticipated future microbeam irradiation treatment doses. The entire heart was irradiated with a dose of 4000 Gy at a dose rate of >6000 Gy s
Identifiants
pubmed: 35787570
pii: S1600577522004489
doi: 10.1107/S1600577522004489
pmc: PMC9255585
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1027-1032Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU 2589/7-1
Organisme : Deutscher Akademischer Austauschdienst
ID : PPP 57444927
Organisme : Forun Rostock Faculty of Medicine
ID : 889035
Informations de copyright
open access.
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