To unwind the biological knots: The DNA/RNA G-quadruplex resolvase RHAU (DHX36) in development and disease.
DHX36
G-quadruplex
RHAU
development and disease
Journal
Animal models and experimental medicine
ISSN: 2576-2095
Titre abrégé: Animal Model Exp Med
Pays: United States
ID NLM: 101726292
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
16
03
2022
accepted:
21
04
2022
pubmed:
6
7
2022
medline:
24
12
2022
entrez:
5
7
2022
Statut:
ppublish
Résumé
The G-quadruplex (G4) sequences are short fragments of 4-interval triple guanine (G) with frequent and ubiquitous distribution in the genome and RNA transcripts. The G4 sequences are usually folded into secondary "knot" structure via Hoogsteen hydrogen bond to exert negative regulation on a variety of biological processes, including DNA replication and transcription, mRNA translation, and telomere maintenance. Recent structural biological and mouse genetics studies have demonstrated that RHAU (DHX36) can bind and unwind the G4 "knots" to modulate embryonic development and postnatal organ function. Deficiency of RHAU gives rise to embryonic lethality, impaired organogenesis, and organ dysfunction. These studies uncovered the pivotal G4 resolvase function of RHAU to release the G4 barrier, which plays fundamental roles in development and physiological homeostasis. This review discusses the latest advancements and findings in deciphering RHAU functions using animal models.
Identifiants
pubmed: 35789129
doi: 10.1002/ame2.12251
pmc: PMC9773310
doi:
Substances chimiques
RNA
63231-63-0
Recombinases
0
DEAD-box RNA Helicases
EC 3.6.4.13
DNA
9007-49-2
Dhx36 protein, mouse
EC 3.6.1.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
542-549Informations de copyright
© 2022 The Authors. Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.
Références
Nat Commun. 2021 Aug 19;12(1):5043
pubmed: 34413292
Genes Dev. 2013 May 1;27(9):991-6
pubmed: 23651854
Development. 2020 Jan 24;147(2):
pubmed: 31980483
Nat Chem Biol. 2007 Apr;3(4):218-21
pubmed: 17322877
Cell Rep. 2015 Oct 27;13(4):723-732
pubmed: 26489465
Animal Model Exp Med. 2022 Dec;5(6):542-549
pubmed: 35789129
Nucleic Acids Res. 2010 Oct;38(18):6219-33
pubmed: 20472641
Oncol Rep. 2020 Feb;43(2):461-470
pubmed: 31894342
Nat Cell Biol. 2011 Aug 07;13(9):1084-91
pubmed: 21822279
Oncogene. 2006 Feb 23;25(8):1125-42
pubmed: 16314846
Nat Commun. 2019 Apr 23;10(1):1855
pubmed: 31015431
J Biol Chem. 2005 Jul 1;280(26):24428-34
pubmed: 15870067
Front Cell Dev Biol. 2020 Jun 17;8:486
pubmed: 32626712
Nat Rev Genet. 2014 Jan;15(1):7-21
pubmed: 24296535
EMBO J. 2003 Mar 17;22(6):1347-58
pubmed: 12628927
Cell. 2013 Jul 3;154(1):26-46
pubmed: 23827673
Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1382-1388
pubmed: 28065761
J Biol Chem. 2008 Dec 12;283(50):34626-34
pubmed: 18842585
Nucleic Acids Res. 2010 Nov;38(20):7022-36
pubmed: 20571090
Nucleic Acids Res. 2011 Nov;39(21):9390-404
pubmed: 21846770
Mol Cell. 2004 Jan 16;13(1):101-11
pubmed: 14731398
Transcription. 2020 Apr;11(2):83-96
pubmed: 32522085
Int J Oncol. 2007 Jul;31(1):69-79
pubmed: 17549406
J Biol Chem. 2021 Jan-Jun;296:100080
pubmed: 33199370
Virus Res. 2022 Feb;309:198658
pubmed: 34929216
J Biol Chem. 2022 Jan;298(1):101449
pubmed: 34838591
Nat Commun. 2019 Jun 3;10(1):2421
pubmed: 31160600
Front Mol Neurosci. 2018 Jun 11;11:171
pubmed: 29942249
Cell Death Dis. 2015 Jan 22;6:e1610
pubmed: 25611385
Science. 2005 Sep 2;309(5740):1559-63
pubmed: 16141072
Nature. 2010 Aug 26;466(7310):1105-9
pubmed: 20622856
PLoS Pathog. 2014 Mar 20;10(3):e1004012
pubmed: 24651521
Nucleic Acids Res. 2012 Feb;40(3):1033-49
pubmed: 21993297
Oncogene. 2017 Mar 2;36(9):1191-1199
pubmed: 27797375
Genome Res. 2021 Sep;31(9):1546-1560
pubmed: 34400476
Fish Shellfish Immunol. 2020 Sep;104:62-73
pubmed: 32526283
J Mol Biol. 2017 Oct 27;429(21):3121-3131
pubmed: 27940037
Cell Mol Life Sci. 2021 Oct;78(19-20):6557-6583
pubmed: 34459951
Biochim Biophys Acta. 2004 Nov 4;1659(1):1-18
pubmed: 15511523
J Bone Miner Res. 2011 Sep;26(9):2161-73
pubmed: 21590736
Front Oncol. 2020 Aug 20;10:1392
pubmed: 32974142
Front Oncol. 2021 Apr 27;11:655757
pubmed: 33987090
Nat Rev Genet. 2009 Jan;10(1):32-42
pubmed: 19065135
J Biol Chem. 2005 Nov 18;280(46):38117-20
pubmed: 16150737
Nat Rev Mol Cell Biol. 2019 Apr;20(4):211-226
pubmed: 30546055
Immunity. 2011 Jun 24;34(6):866-78
pubmed: 21703541
Am J Cancer Res. 2020 Dec 01;10(12):4211-4233
pubmed: 33414996
Blood. 2012 May 3;119(18):4291-300
pubmed: 22422825
Nature. 2009 Mar 12;458(7235):223-7
pubmed: 19182780
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Sep;34(5):655-61
pubmed: 12198572
ACS Omega. 2020 Sep 16;5(38):24916-24926
pubmed: 33015511
Comput Struct Biotechnol J. 2021 Apr 23;19:2526-2536
pubmed: 34025941
Nature. 2018 Jun;558(7710):465-469
pubmed: 29899445
J Biol Chem. 2016 Mar 4;291(10):5355-72
pubmed: 26740632
EMBO Rep. 2010 Mar;11(3):180-6
pubmed: 20168331
Biol Chem. 2020 Dec 16;402(5):593-604
pubmed: 33857359