Fast imaging-based single particle analysis method for solubility determination.
Dissolution
Image analysis
Miniaturization
Optical imaging
Single particle
Solubility
Journal
International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127
Informations de publication
Date de publication:
25 Aug 2022
25 Aug 2022
Historique:
received:
11
04
2022
revised:
24
06
2022
accepted:
30
06
2022
pubmed:
7
7
2022
medline:
17
8
2022
entrez:
6
7
2022
Statut:
ppublish
Résumé
The solubility and dissolution rates of chemical compounds are crucial properties in several fields of industry and research. However, accurate, rapid and green methods for their measurement, which only consume micrograms of compound, are lacking. Here, the unique approach of non-specific, image-based single particle analysis (SPA) for solubility testing is directly compared to and thus validated on the mid-solubility range with the current gold standard shake-flask method with UV-Vis spectroscopy employed for determining sample concentrations. Five biologically active compounds representing a range of physicochemical properties including pK
Identifiants
pubmed: 35792233
pii: S0378-5173(22)00531-2
doi: 10.1016/j.ijpharm.2022.121976
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
121976Informations de copyright
Copyright © 2022. Published by Elsevier B.V.