Characterization and diagnostic potential of R
Brain iron
Convolutional neural network
Diagnostic marker
Progressive supranuclear palsy
R2*
Journal
Parkinsonism & related disorders
ISSN: 1873-5126
Titre abrégé: Parkinsonism Relat Disord
Pays: England
ID NLM: 9513583
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
29
03
2022
revised:
08
06
2022
accepted:
24
06
2022
pubmed:
7
7
2022
medline:
24
8
2022
entrez:
6
7
2022
Statut:
ppublish
Résumé
Iron accumulation in subcortical brain nuclei has been shown to be differentially increased in atypical parkinsonian disorders. It is unclear whether the patterns of iron accumulation are consistent between variants of progressive supranuclear palsy (PSP) and their diagnostic utility in early to moderately advanced stages of the diseases. Brain iron content (R Significant group differences in R Iron accumulation in subcortical brain nuclei has distinct correlated patterns in PSP-P and PSP-RS, which could be reflecting different pathophysiological mechanisms. Increased iron content in these nuclei appears to be a predictor for atypical parkinsonian disorders such as PSP and MSA. Further studies are required to reproduce this finding and elucidate the evolution of these patterns over the course of the disease.
Identifiants
pubmed: 35792337
pii: S1353-8020(22)00217-6
doi: 10.1016/j.parkreldis.2022.06.021
pii:
doi:
Substances chimiques
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-48Informations de copyright
Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.