Delayed increase of plasma selenoproteins and absence of side effect induced by infusion of pharmacological dose of sodium selenite in septic shock: Secondary analysis of a multicenter, randomized controlled trial.
Glutathione peroxidase
Organ failure
Selenoprotein P
Sepsis
Sodium Selenite
Journal
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)
ISSN: 1878-3252
Titre abrégé: J Trace Elem Med Biol
Pays: Germany
ID NLM: 9508274
Informations de publication
Date de publication:
Sep 2022
Sep 2022
Historique:
received:
30
01
2022
revised:
14
06
2022
accepted:
24
06
2022
pubmed:
7
7
2022
medline:
9
8
2022
entrez:
6
7
2022
Statut:
ppublish
Résumé
In sepsis, neutrophil respiratory bursts participate in endothelium damage, the first step to multiple organ failure. In plasma two antioxidant selenoenzymes, which protect the endothelium, decrease: selenoprotein-P, and to a lesser extent glutathione peroxidase (GPX3). Sodium selenite (Na At baseline, plasma Se was about a quarter of reference values. From baseline to day-4 plasma Se, selenoprotein-P and GPX3 significantly increased by 3.9, 2.7 and 1.8 respectively in the Na Continuous infusion of Na
Sections du résumé
BACKGROUND
BACKGROUND
In sepsis, neutrophil respiratory bursts participate in endothelium damage, the first step to multiple organ failure. In plasma two antioxidant selenoenzymes, which protect the endothelium, decrease: selenoprotein-P, and to a lesser extent glutathione peroxidase (GPX3). Sodium selenite (Na
MAIN RESULTS
RESULTS
At baseline, plasma Se was about a quarter of reference values. From baseline to day-4 plasma Se, selenoprotein-P and GPX3 significantly increased by 3.9, 2.7 and 1.8 respectively in the Na
CONCLUSION
CONCLUSIONS
Continuous infusion of Na
Identifiants
pubmed: 35793609
pii: S0946-672X(22)00111-0
doi: 10.1016/j.jtemb.2022.127031
pii:
doi:
Substances chimiques
Lactates
0
Selenoprotein P
0
Selenoproteins
0
Glutathione Peroxidase
EC 1.11.1.9
Selenium
H6241UJ22B
Sodium Selenite
HIW548RQ3W
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
127031Informations de copyright
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