Epilepsy and Cognitive Impairment in Childhood and Adolescence: A Mini-Review.
Epilepsy
anti-seizure medication
cognitive impairment
ganaxolone
gene therapy
intellectual disability
ketogenic diet
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2023
2023
Historique:
received:
05
01
2022
revised:
28
02
2022
accepted:
26
04
2022
pmc-release:
15
12
2023
medline:
22
6
2023
pubmed:
8
7
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Managing epilepsy in people with an intellectual disability remains a therapeutic challenge and must take into account additional issues such as diagnostic difficulties and frequent drug resistance. Advances in genomic technologies improved our understanding of epilepsy and raised the possibility to develop patients-tailored treatments acting on the key molecular mechanisms involved in the development of the disease. In addition to conventional antiseizure medications (ASMs), ketogenic diet, hormone therapy and epilepsy surgery play an important role, especially in cases of drugresistance. This review aims to provide a comprehensive overview of the mainfactors influencing cognition in children and adolescents with epilepsy and the main therapeutic options available for the epilepsies associated with intellectual disability.
Identifiants
pubmed: 35794776
pii: CN-EPUB-125013
doi: 10.2174/1570159X20666220706102708
pmc: PMC10514538
doi:
Types de publication
Review
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1646-1665Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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