Impact of bacterial strain acquisition in the lung of patients with COPD: the AERIS study.
Exacerbation
Moraxella catarrhalis
acquisition
apparition
bacteria
non-typeable Haemophilus influenzae
Journal
Infectious diseases (London, England)
ISSN: 2374-4243
Titre abrégé: Infect Dis (Lond)
Pays: England
ID NLM: 101650235
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
pubmed:
8
7
2022
medline:
15
9
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Bacterial infections are associated with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the mechanism is incompletely understood. In a COPD observational study (NCT01360398), sputum samples were collected monthly at the stable state and exacerbation. The culture results confirmed a significant association with exacerbation only for NTHi species presence (OR 2.28; 95% confidence interval [CI]: 1.12-4.64) and strain apparition (OR 2.38; 95% CI: 1.08-5.27). For The results confirm that NTHi and
Sections du résumé
BACKGROUND
Bacterial infections are associated with acute exacerbations of chronic obstructive pulmonary disease (AECOPD), but the mechanism is incompletely understood.
METHOD
In a COPD observational study (NCT01360398), sputum samples were collected monthly at the stable state and exacerbation.
RESULTS
The culture results confirmed a significant association with exacerbation only for NTHi species presence (OR 2.28; 95% confidence interval [CI]: 1.12-4.64) and strain apparition (OR 2.38; 95% CI: 1.08-5.27). For
CONCLUSIONS
The results confirm that NTHi and
Identifiants
pubmed: 35794793
doi: 10.1080/23744235.2022.2092648
doi:
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
784-793Investigateurs
J Alnajar
(J)
R Anderson
(R)
E Aris
(E)
W R Ballou
(WR)
A Barton
(A)
S Bourne
(S)
M Caubet
(M)
S C Clarke
(SC)
D W Cleary
(DW)
C Cohet
(C)
N A Coombs
(NA)
K Osman
(K)
J-M Devaster
(JM)
V Devine
(V)
N Devos
(N)
E Dineen
(E)
T Elliott
(T)
R Gladstone
(R)
S Harden
(S)
J Jefferies
(J)
V L Kim
(VL)
P Moris
(P)
K K Ostridge
(KK)
T G Pascal
(TG)
M Peeters
(M)
S Schoonbroodt
(S)
B Sente
(B)
K J Staples
(KJ)
A C Tuck
(AC)
L Welch
(L)
V Weynants
(V)
T M A Wilkinson
(TMA)
A P Williams
(AP)
N P Williams
(NP)
C Woelk
(C)
M Wojtas
(M)
S A Wootton
(SA)