EZH2 Promotes T Follicular Helper Cell Differentiation Through Enhancing STAT3 Phosphorylation in Patients With Primary Sjögren's Syndrome.
STAT3
T cell
T follicular helper cell
enhancer zeste homolog 2 (EZH2)
primary Sjögren’s syndrome
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
18
04
2022
accepted:
16
05
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
9
7
2022
Statut:
epublish
Résumé
Enhancer of zeste homolog 2 (EZH2) is an epigenetic regulator that plays an essential role in immune system development and autoimmune diseases. This study aimed to characterize the role of EZH2 in the pathogenesis of primary Sjögren's syndrome (pSS). We analyzed EZH2 expression in two transcriptomic datasets of peripheral blood mononuclear cells (PBMCs) from pSS patients and healthy controls. We measured EZH2 expression in CD4 EZH2 was upregulated in GSE164885 and GSE48378. EZH2 expression was higher in pSS CD4 EZH2 expression was abnormally elevated in pSS CD4
Identifiants
pubmed: 35795677
doi: 10.3389/fimmu.2022.922871
pmc: PMC9252457
doi:
Substances chimiques
STAT3 Transcription Factor
0
STAT3 protein, human
0
EZH2 protein, human
EC 2.1.1.43
Enhancer of Zeste Homolog 2 Protein
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
922871Informations de copyright
Copyright © 2022 He, Yang, Chen, Liu, Lyu, Zeng, Wang, Li, Wang, Chen and Zhang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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