Plasma and memory antibody responses to Gamma SARS-CoV-2 provide limited cross-protection to other variants.
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
05 09 2022
05 09 2022
Historique:
received:
28
02
2022
revised:
17
05
2022
accepted:
13
06
2022
entrez:
7
7
2022
pubmed:
8
7
2022
medline:
12
7
2022
Statut:
ppublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to be a global problem in part because of the emergence of variants of concern that evade neutralization by antibodies elicited by prior infection or vaccination. Here we report on human neutralizing antibody and memory responses to the Gamma variant in a cohort of hospitalized individuals. Plasma from infected individuals potently neutralized viruses pseudotyped with Gamma SARS-CoV-2 spike protein, but neutralizing activity against Wuhan-Hu-1-1, Beta, Delta, or Omicron was significantly lower. Monoclonal antibodies from memory B cells also neutralized Gamma and Beta pseudoviruses more effectively than Wuhan-Hu-1. 69% and 34% of Gamma-neutralizing antibodies failed to neutralize Delta or Wuhan-Hu-1. Although Class 1 and 2 antibodies dominate the response to Wuhan-Hu-1 or Beta, 54% of antibodies elicited by Gamma infection recognized Class 3 epitopes. The results have implications for variant-specific vaccines and infections, suggesting that exposure to variants generally provides more limited protection to other variants.
Identifiants
pubmed: 35796685
pii: 213338
doi: 10.1084/jem.20220367
pmc: PMC9270183
pii:
doi:
Substances chimiques
Antibodies, Neutralizing
0
Antibodies, Viral
0
Membrane Glycoproteins
0
Spike Glycoprotein, Coronavirus
0
Viral Envelope Proteins
0
spike protein, SARS-CoV-2
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bulgari Women & Science Fellowship
Organisme : NIAID NIH HHS
ID : R01 AI078788
Pays : United States
Organisme : Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Organisme : NIAID NIH HHS
ID : P01 AI138938
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : Instituto Serrapilheira
Organisme : NIAID NIH HHS
ID : R37 AI064003
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI111825
Pays : United States
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 404096/2020
Organisme : Rede Corona-ômica Brazil Ministério da Ciência, Tecnologia e Inovações/Financiadora de Estudos e Projetos
Informations de copyright
© 2022 Agudelo et al.
Références
Cell. 2020 Jul 9;182(1):73-84.e16
pubmed: 32425270
Nature. 2021 Dec;600(7889):517-522
pubmed: 34619745
Proc Natl Acad Sci U S A. 2021 Sep 7;118(36):
pubmed: 34417349
Nat Med. 2021 Apr;27(4):620-621
pubmed: 33558724
J Virol. 2021 Nov 9;95(23):e0131321
pubmed: 34549975
Nature. 2021 Apr;592(7855):616-622
pubmed: 33567448
Nature. 2021 Dec;600(7889):512-516
pubmed: 34544114
Nat Med. 2021 Jul;27(7):1205-1211
pubmed: 34002089
Nature. 2019 Feb;566(7744):393-397
pubmed: 30664748
Cell Host Microbe. 2022 Jan 12;30(1):53-68.e12
pubmed: 34921776
Science. 2022 Feb 18;375(6582):782-787
pubmed: 35076281
Cell. 2021 Apr 29;184(9):2332-2347.e16
pubmed: 33761326
Cell. 2021 May 27;184(11):2939-2954.e9
pubmed: 33852911
Nature. 2020 Aug;584(7821):437-442
pubmed: 32555388
Elife. 2020 Oct 28;9:
pubmed: 33112236
Science. 2021 Aug 13;373(6556):818-823
pubmed: 34016740
Cell. 2021 Apr 29;184(9):2372-2383.e9
pubmed: 33743213
J Exp Med. 2014 Nov 17;211(12):2361-72
pubmed: 25385756
Immunity. 2021 Aug 10;54(8):1853-1868.e7
pubmed: 34331873
J Exp Med. 2020 Nov 2;217(11):
pubmed: 32692348
Nature. 2021 May;593(7857):142-146
pubmed: 33780970
Cell. 2020 Aug 20;182(4):843-854.e12
pubmed: 32673567
Nat Rev Microbiol. 2021 Jul;19(7):409-424
pubmed: 34075212
Nature. 2021 Apr;592(7854):438-443
pubmed: 33690265
Nat Med. 2021 Apr;27(4):622-625
pubmed: 33654292
Cell. 2021 Apr 29;184(9):2384-2393.e12
pubmed: 33794143
N Engl J Med. 2021 Jun 3;384(22):2161-2163
pubmed: 33826816
Immunity. 2019 Jun 18;50(6):1513-1529.e9
pubmed: 31126879
Emerg Infect Dis. 2021 Apr;27(4):
pubmed: 33567247
Sci Adv. 2021 Sep 03;7(36):eabj5365
pubmed: 34516917
Cell Host Microbe. 2021 Mar 10;29(3):463-476.e6
pubmed: 33592168
Sci Immunol. 2021 Feb 23;6(56):
pubmed: 33622975
Nat Rev Genet. 2021 Dec;22(12):757-773
pubmed: 34535792
Science. 2020 Aug 21;369(6506):1014-1018
pubmed: 32540904
Cell Host Microbe. 2021 Mar 10;29(3):477-488.e4
pubmed: 33535027
Nature. 2019 Feb;566(7744):398-402
pubmed: 30760926
Nature. 2020 Aug;584(7819):115-119
pubmed: 32454513
Cell Rep. 2021 Sep 28;36(13):109760
pubmed: 34534459
Science. 2020 Aug 21;369(6506):956-963
pubmed: 32540903
Cell Host Microbe. 2021 May 12;29(5):747-751.e4
pubmed: 33887205
Science. 2021 May 21;372(6544):815-821
pubmed: 33853970
N Engl J Med. 2022 Feb 10;386(6):599-601
pubmed: 35030645
J Virol. 2021 Mar 1;:
pubmed: 33649194
Lancet Microbe. 2021 Oct;2(10):e527-e535
pubmed: 34258603
Cell. 2021 Apr 29;184(9):2348-2361.e6
pubmed: 33730597
Nature. 2021 Mar;591(7851):639-644
pubmed: 33461210
Cell. 2021 Mar 4;184(5):1171-1187.e20
pubmed: 33621484
Front Immunol. 2019 Oct 09;10:2365
pubmed: 31649674
Cell. 2020 Sep 3;182(5):1284-1294.e9
pubmed: 32730807
Proc Natl Acad Sci U S A. 2021 Jul 6;118(27):
pubmed: 34140350
Nature. 2020 Dec;588(7839):682-687
pubmed: 33045718
Braz J Infect Dis. 2021 May-Jun;25(3):101588
pubmed: 34102147
Science. 2020 Aug 7;369(6504):643-650
pubmed: 32540902
Cell. 2020 Aug 20;182(4):828-842.e16
pubmed: 32645326
Clin Infect Dis. 2021 Sep 15;73(6):e1337-e1344
pubmed: 33851216
Nature. 2021 Jul;595(7867):426-431
pubmed: 34126625
J Exp Med. 2021 May 3;218(5):
pubmed: 33831141
Nature. 2021 May;593(7857):130-135
pubmed: 33684923