Detection of PRRSV-2 alone and co-localized with CD163 positive macrophages in porcine placental areolae.
Areola
Histotrophic
Immunofluorescence
Maternal fetal interface
Porcine reproductive and respiratory syndrome
Journal
Veterinary immunology and immunopathology
ISSN: 1873-2534
Titre abrégé: Vet Immunol Immunopathol
Pays: Netherlands
ID NLM: 8002006
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
23
12
2021
revised:
25
04
2022
accepted:
25
06
2022
pubmed:
8
7
2022
medline:
27
7
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
The porcine epitheliochorial placenta creates a barrier for the transplacental transfer of some nutrients from the dam to the fetus, as well as feto-lethal viruses such as porcine reproductive and respiratory syndrome virus 2 (PRRSV-2). Areolae are specialized structures within the porcine placenta with a high absorptive and substance transport capacity that facilitate embryonic development. The overarching aim of this study was to characterize the localization of PRRSV-2 in and adjacent to areolae to provide insight into whether transplacental transmission might occur through placental areolae. Control (CON) plus three phenotypic fetal groups were selected based on levels of virus in fetal placenta, sera and thymus, to determine if fetal resilience was related to differences in PRRSV-2 localization, alone or co-localized with CD163
Identifiants
pubmed: 35797846
pii: S0165-2427(22)00077-0
doi: 10.1016/j.vetimm.2022.110457
pii:
doi:
Substances chimiques
Antigens, CD
0
Antigens, Differentiation, Myelomonocytic
0
CD163 antigen
0
Receptors, Cell Surface
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110457Informations de copyright
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