Plasma cell but not CD20-mediated B-cell depletion protects from bleomycin-induced lung fibrosis.

Humans Mice Animals Bleomycin / pharmacology Plasma Cells Idiopathic Pulmonary Fibrosis / drug therapy Lung / metabolism Lung Diseases, Interstitial / chemically induced

Journal

The European respiratory journal
ISSN: 1399-3003
Titre abrégé: Eur Respir J
Pays: England
ID NLM: 8803460

Informations de publication

Date de publication:
11 2022
Historique:
received: 30 05 2021
accepted: 16 05 2022
pubmed: 8 7 2022
medline: 29 11 2022
entrez: 7 7 2022
Statut: epublish

Résumé

Idiopathic pulmonary fibrosis (IPF) is an interstitial lung disease associated with chronic inflammation and tissue remodelling leading to fibrosis, reduced pulmonary function, respiratory failure and death. Bleomycin (Blm)-induced lung fibrosis in mice replicates several clinical features of human IPF, including prominent lymphoid aggregates of predominantly B-cells that accumulate in the lung adjacent to areas of active fibrosis. We have shown previously a requirement for B-cells in the development of Blm-induced lung fibrosis in mice. To determine the therapeutic potential of inhibiting B-cell function in pulmonary fibrosis, we examined the effects of anti-CD20 B-cell ablation therapy to selectively remove mature B-cells from the immune system and inhibit Blm-induced lung fibrosis. Anti-CD20 B-cell ablation did not reduce fibrosis in this model; however, immune phenotyping of peripheral blood and lung resident cells revealed that anti-CD20-treated mice retained a high frequency of CD19

Identifiants

DOI: 10.1183/13993003.01469-2021 PMID: 35798357 PMC: PMC9684624
pubmed: 35798357
pii: 13993003.01469-2021
doi: 10.1183/13993003.01469-2021
pmc: PMC9684624
pii:
doi:

Substances chimiques

Bleomycin 11056-06-7

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright ©The authors 2022.

Déclaration de conflit d'intérêts

Conflict of interest: S.E. Mutsaers, C.M. Prêle, R.J. McAnulty, G.J. Laurent, G. Hoyne, D.A. Knight, R.J. O'Donoghue and M. Ernst received grants from National Health and Medical Research Council (NHMRC), project grants ID APP1067511. R.J. McAnulty, S.E. Mutsaers, C.M. Prêle and D.R. Pearce received grants from British Lung Foundation, project grant number PPRG15-10. T. Miles reports that Genentech provided the anti-CD20 antibody, and received UWA Research Training Program Scholarship and the Lung Foundation Australia Bill van Nierop PhD Scholarship. All other authors have nothing to disclose.

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Auteurs

Cecilia M Prêle (CM)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Nedlands, Australia.
C.M. Prêle and T. Miles have contributed equally to this work and share first authorship.

Tylah Miles (T)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
C.M. Prêle and T. Miles have contributed equally to this work and share first authorship.

David R Pearce (DR)

Centre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK.
ORCID: 0000-0001-8443-2924

Robert J O'Donoghue (RJ)

Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia.

Chris Grainge (C)

Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia.
Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, Australia.

Lucy Barrett (L)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.

Kimberly Birnie (K)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.

Andrew D Lucas (AD)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.

Svetlana Baltic (S)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.

Matthias Ernst (M)

Olivia Newton John Cancer Research Institute and La Trobe University School of Cancer Medicine, Heidelberg, Australia.
ORCID: 0000-0002-6399-1177

Catherine Rinaldi (C)

Centre for Microscopy Characterisation and Analysis, The University of Western Australia, Nedlands, Australia.

Geoffrey J Laurent (GJ)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Nedlands, Australia.

Darryl A Knight (DA)

Providence Health Care Research Institute, Vancouver, BC, Canada.
ORCID: 0000-0002-4064-6127

Mark Fear (M)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
Burn Injury Research Unit, School of Biomedical Sciences, The University of Western Australia, Nedlands, Australia.

Gerard Hoyne (G)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
The University of Notre Dame Australia, Fremantle, Australia.

Robin J McAnulty (RJ)

Centre for Inflammation and Tissue Repair, Division of Medicine, University College London, London, UK.
S.E. Mutsaers and R.J. McAnulty have contributed equally to this work and share senior authorship.

Steven E Mutsaers (SE)

Institute for Respiratory Health, The University of Western Australia, Nedlands, Australia.
Centre for Cell Therapy and Regenerative Medicine, School of Biomedical Sciences, The University of Western Australia, Nedlands, Australia.
S.E. Mutsaers and R.J. McAnulty have contributed equally to this work and share senior authorship.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Eucaryotes › Animaux › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Glycopeptides › Bléomycine › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Plasmocytes › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Fibrose pulmonaire idiopathique › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Appareil respiratoire › Poumon › Plasma cell but not CD20-mediated B-cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Pneumopathies interstitielles › Plasma cell but not CD20-mediated B-cell...