Autoimmune/autoinflammatory syndrome induced by adjuvants: a focus on silicone.
ASIA
Breast implant illness
Silicone
Silicone breast implant
Journal
Clinical rheumatology
ISSN: 1434-9949
Titre abrégé: Clin Rheumatol
Pays: Germany
ID NLM: 8211469
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
18
01
2022
accepted:
29
06
2022
revised:
30
05
2022
pubmed:
8
7
2022
medline:
19
10
2022
entrez:
7
7
2022
Statut:
ppublish
Résumé
Autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA) was first described in 2011 to cover disorders characterized by dysregulation of the immune system after exposure to an adjuvant. In the present review, the authors focus on silicone-induced ASIA. In the last two decades, there has been worldwide increase in the use of silicone breast implant (SBI) as an aesthetic procedure, raising concerns for possible effects on the immune system, especially in people who already have previous immune dysregulation. The authors did a critical review of the most important articles referring to silicone-induced ASIA, including most recent studies regarding physiopathologic mechanism. Despite large-scale epidemiological studies conducted to assess the association between SBI and autoimmune/rheumatic disorders, the results remain inconclusive, and the debate over the safety of SBIs remains heated. The explantation of silicone breast has been indicated for silicone-induced ASIA with improvement of unspecific symptoms in the majority of patients; however, the outcome seems different in patients with definitive autoimmune rheumatic disease (AIRD). There is no prospective study evaluating the risk of flares after SBI in patients who already have an AIRD. Therefore, based on the literature, we cannot contraindicate the procedure; however, we need to advertise about the risk of ASIA to the patients with AIRD. Long-term safety and implant-related outcomes should be discussed with these patients, considering each case individually, assessing genetic and environmental factors, and determining if the autoimmune disease is in remission or not, for shared decision among patient and the physician.
Identifiants
pubmed: 35798923
doi: 10.1007/s10067-022-06274-0
pii: 10.1007/s10067-022-06274-0
doi:
Substances chimiques
Adjuvants, Immunologic
0
Silicones
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
3275-3283Informations de copyright
© 2022. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).
Références
Shoenfeld Y, Agmon-Levin N (2011) ‘ASIA’ - autoimmune/inflammatory syndrome induced by adjuvants. J Autoimmunity 36(1):4–8. https://doi.org/10.1016/j.jaut.2010.07.003
doi: 10.1016/j.jaut.2010.07.003
Schijns VE (2000) Immunological concepts of vaccine adjuvant activity. Curr opinion Immunol 12(4):456–463. https://doi.org/10.1016/s0952-7915(00)00120-5
doi: 10.1016/s0952-7915(00)00120-5
Audibert F (2003) Adjuvants for vaccines, a quest. Int Immunopharmacol 3(8):1187–1193. https://doi.org/10.1016/S1567-5769(03)00011-0
doi: 10.1016/S1567-5769(03)00011-0
pubmed: 12860174
Audibert FM, Lise LD (1993) Adjuvants: current status, clinical perspectives and future prospects. Immunol Today 14(6):281–284. https://doi.org/10.1016/0167-5699(93)90046-N
doi: 10.1016/0167-5699(93)90046-N
pubmed: 8104409
Awate S, Babiuk LA, Mutwiri G (2013) Mechanisms of action of adjuvants. Front Immunol 4:114. https://doi.org/10.3389/fimmu.2013.00114
doi: 10.3389/fimmu.2013.00114
pubmed: 23720661
pmcid: 3655441
Watad A, Bragazzi NL, McGonagle D, Adawi M, Bridgewood C, Damiani G, Alijotas-Reig J, Esteve-Valverde E, Quaresma M, Amital H, Shoenfeld Y (2019) Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) demonstrates distinct autoimmune and autoinflammatory disease associations according to the adjuvant subtype: insights from an analysis of 500 cases. Clin Immunol (Orlando Fla) 203:1–8. https://doi.org/10.1016/j.clim.2019.03.007
doi: 10.1016/j.clim.2019.03.007
Zafrir Y, Agmon-Levin N, Paz Z, Shilton T, Shoenfeld Y (2012) Autoimmunity following hepatitis B vaccine as part of the spectrum of ‘autoimmune (auto-inflammatory) syndrome induced by adjuvants’ (ASIA): analysis of 93 cases. Lupus 21(2):146–152. https://doi.org/10.1177/0961203311429318
doi: 10.1177/0961203311429318
pubmed: 22235045
Ameratunga R, Gillis D, Gold M, Linneberg A, Elwood JM (2017) Evidence refuting the existence of autoimmune/autoinflammatory syndrome induced by adjuvants (ASIA). J Allergy Clin Immunol Pract 5(6):1551-1555.e1. https://doi.org/10.1016/j.jaip.2017.06.033
doi: 10.1016/j.jaip.2017.06.033
pubmed: 28888842
Collins MM, Tang T, Slack R, Sintasath D, Hartzman RJ, Ng J, Hurley CK, Ng J, Hurley CK (2000) The relative frequencies of HLA-DRB1*01 alleles in the major US populations. Tissue Antigens 55(1):48–52. https://doi.org/10.1034/j.1399-0039.2000.550108.x
doi: 10.1034/j.1399-0039.2000.550108.x
pubmed: 10703608
Cohen Tervaert JW (2018) Autoinflammatory/autoimmunity syndrome induced by adjuvants (ASIA; Shoenfeld’s syndrome): a new flame. Autoimmun Rev 17(12):1259–1264. https://doi.org/10.1016/j.autrev.2018.07.003
doi: 10.1016/j.autrev.2018.07.003
pubmed: 30316995
Cohen Tervaert JW, Kappel RM (2013) Silicone implant incompatibility syndrome (SIIS): a frequent cause of ASIA (Shoenfeld’s syndrome). Immunol Res 56(2–3):293–298. https://doi.org/10.1007/s12026-013-8401-3
doi: 10.1007/s12026-013-8401-3
pubmed: 23576058
Hodge SD, Miles MG & Pancio JB. Everything you wanted to know about breast augmentation surgery but were afraid to ask: a medical - legal overview, 12 Fla. A&M U. L. Rev. 103 (2016). Available at: https://commons.law.famu.edu/famulawreview/vol12/iss1/5
Caravantes-Cortes MI, Roldan-Valadez E, Zwojewski-Martinez RD, Salazar-Ruiz SY, Carballo-Zarate AA (2020) Breast prosthesis syndrome: pathophysiology and management algorithm. Aesthetic Plast Surg 44(5):1423–1437. https://doi.org/10.1007/s00266-020-01663-9
doi: 10.1007/s00266-020-01663-9
pubmed: 32152711
Gleeson JP, Redmond HP, O’Reilly S (2019) Siliconosis and the long-term implications of silent breast implant rupture. Breast J 25(5):1002–1003. https://doi.org/10.1111/tbj.13393
doi: 10.1111/tbj.13393
pubmed: 31219206
Caldeira M, Ferreira AC (2012) Siliconosis: autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Israel Medical Assoc J IMAJ 14(2):137–138
Maijers MC, de Blok CJ, Niessen FB, van der Veldt AA, Ritt MJ, Winters HA, Kramer MH, Nanayakkara PW (2013) Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study. Neth J Med 71(10):534–540
pubmed: 24394743
U.S. Food and Drug Administration (2011). FDA update on the safety of silicone gel-filled breast implants. Available at: http://www.fda.gov/downloads/MedicalDevices/ProductsandMedicalProcedures/ImplantsandProsthetics/BreastImplants/UCM260090.pdf .
McDonald AH, Weir K, Schneider M, Gudenkauf L, Sanger JR (1998) Silicone gel enhances the development of autoimmune disease in New Zealand black mice but fails to induce it in BALB/cAnPt mice. Clin Immunol Immunopathol 87(3):248–255. https://doi.org/10.1006/clin.1998.4532
doi: 10.1006/clin.1998.4532
pubmed: 9646834
Schaefer CJ, Wooley PH (1999) The influence of silicone implantation on murine lupus in MRL lpr/lpr mice. J Rheumatol 26(10):2215–2221
pubmed: 10529143
Schaefer CJ (1997) The influence of silicone implantation on experimental models of autoimmunity. EDT Collect Wayne State Univ.
Ryu AJ, Glazebrook KN, Samreen N, Bauer PR, Yi ES, Ryu JH (2018) Spectrum of chronic complications related to silicone leakage and migration. Am J Med 131(11):1383–1386. https://doi.org/10.1016/j.amjmed.2018.03.041
doi: 10.1016/j.amjmed.2018.03.041
pubmed: 29680487
Soriano A, Butnaru D, Shoenfeld Y (2014) Long-term inflammatory conditions following silicone exposure: the expanding spectrum of the autoimmune/inflammatory syndrome induced by adjuvants (ASIA). Clin Exp Rheumatol 32(2):151–154
pubmed: 24739519
Ellis TM, Hardt NS, Campbell L, Piacentini DA, Atkinson MA (1997) Cellular immune reactivities in women with silicone breast implants: a preliminary investigation. Ann Allergy Asthma Immunol 79(2):151–154. https://doi.org/10.1016/S1081-1206(10)63102-X
doi: 10.1016/S1081-1206(10)63102-X
pubmed: 9291420
Wolfram D, Rabensteiner E, Grundtman C, Böck G, Mayerl C, Parson W, Almanzar G, Hasenöhrl C, Piza-Katzer H, Wick G (2012) T regulatory cells and TH17 cells in peri-silicone implant capsular fibrosis. Plast Reconstr Surg 129(2):327e–337e. https://doi.org/10.1097/PRS.0b013e31823aeacf
doi: 10.1097/PRS.0b013e31823aeacf
pubmed: 22286447
Goldblum RM, Pelley RP, O’Donell AA, Pyron D, Heggers JP (1992) Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts. Lancet (London England) 340(8818):510–513. https://doi.org/10.1016/0140-6736(92)91710-p
doi: 10.1016/0140-6736(92)91710-p
Zandman-Goddard G, Blank M, Ehrenfeld M, Gilburd B, Peter J, Shoenfeld Y (1999) A comparison of autoantibody production in asymptomatic and symptomatic women with silicone breast implants. J Rheumatol 26(1):73–77
pubmed: 9918243
Teuber SS, Rowley MJ, Yoshida SH, Ansari AA, Gershwin ME (1993) Anti-collagen autoantibodies are found in women with silicone breast implants. J Autoimmunity 6(3):367–377. https://doi.org/10.1006/jaut.1993.1031
doi: 10.1006/jaut.1993.1031
Karlson EW, Lee IM, Cook NR, Buring JE, Hennekens CH, Bloch KJ (2001) Serologic evaluations of women exposed to breast implants. J Rheumatol 28(7):1523–1530
pubmed: 11469457
Dush DM (2001) Breast implants and illness: a model of psychological factors. Ann Rheum Dis 60(7):653–657. https://doi.org/10.1136/ard.60.7.653
doi: 10.1136/ard.60.7.653
pubmed: 11406518
pmcid: 1753733
Kappel RM, Boer LL, Dijkman H (2016) Gel bleed and rupture of silicone breast implants investigated by light-, electron microscopy and energy dispersive X-ray analysis of internal organs and nervous tissue. Clin Med Rev Case Rep 3:087
doi: 10.23937/2378-3656/1410087
Lee M, Ponraja G, McLeod K, Chong S (2020) Breast implant illness: a biofilm hypothesis. Plast Reconstr Surg Glob Open 8(4):e2755. https://doi.org/10.1097/GOX.0000000000002755
doi: 10.1097/GOX.0000000000002755
pubmed: 32440423
pmcid: 7209857
Babensee JE (2008) Interaction of dendritic cells with biomaterials. Semin Immunol 20(2):101–108. https://doi.org/10.1016/j.smim.2007.10.013
doi: 10.1016/j.smim.2007.10.013
pubmed: 18054498
Halpert G, Watad A, Tsur AM, Dotan A, Quiros-Lim HE, Heidecke H, Gilburd B, Haik J, Levy Y, Blank M, Amital H, Shoenfeld Y (2021) Autoimmune dysautonomia in women with silicone breast implants. J Autoimmun 120:102631. https://doi.org/10.1016/j.jaut.2021.102631
doi: 10.1016/j.jaut.2021.102631
pubmed: 33799099
Cohen Tervaert JW, Mohazab N, Redmond D, van Eeden C, Osman M (2022) Breast implant illness: scientific evidence of its existence. Expert Rev Clin Immunol 18(1):15–29. https://doi.org/10.1080/1744666X.2022.2010546
doi: 10.1080/1744666X.2022.2010546
pubmed: 34882509
Hennekens CH, Lee IM, Cook NR, Hebert PR, Karlson EW, LaMotte F, Manson JE, Buring JE (1996) Self-reported breast implants and connective-tissue diseases in female health professionals. A retrospective cohort study. JAMA 275(8):616–621
doi: 10.1001/jama.1996.03530320040032
Janowsky EC, Kupper LL, Hulka BS (2000) Meta-analyses of the relation between silicone breast implants and the risk of connective-tissue diseases. N Engl J Med 342(11):781–790. https://doi.org/10.1056/NEJM200003163421105
doi: 10.1056/NEJM200003163421105
pubmed: 10717013
Fryzek JP, Signorello LB, Hakelius L, Feltelius N, Ringberg A, Blot WJ, McLaughlin JK, Nyren O (2001) Self-reported symptoms among women after cosmetic breast implant and breast reduction surgery. Plast Reconstr Surg 107(1):206–213. https://doi.org/10.1097/00006534-200101000-00034
doi: 10.1097/00006534-200101000-00034
pubmed: 11176625
Brown SL, Pennello G, Berg WA, Soo MS, Middleton MS (2001) Silicone gel breast implant rupture, extracapsular silicone, and health status in a population of women. J Rheumatol 28(5):996–1003
pubmed: 11361228
Balk EM, Earley A, Avendano EA, Raman G (2016) Long-term health outcomes in women with silicone gel breast implants: a systematic review. Ann Intern Med 164(3):164–175. https://doi.org/10.7326/M15-1169
doi: 10.7326/M15-1169
pubmed: 26550776
Colaris M, de Boer M, van der Hulst RR, Cohen Tervaert JW (2017) Two hundred cases of ASIA syndrome following silicone implants: a comparative study of 30 years and a review of current literature. Immunol Res 65(1):120–128. https://doi.org/10.1007/s12026-016-8821-y
doi: 10.1007/s12026-016-8821-y
pubmed: 27406737
Goren I, Segal G, Shoenfeld Y (2015) Autoimmune/inflammatory syndrome induced by adjuvant (ASIA) evolution after silicone implants. Who is at risk? Clin Rheumatol 34(10):1661–1666. https://doi.org/10.1007/s10067-015-2931-0
doi: 10.1007/s10067-015-2931-0
pubmed: 25877803
de Boer M, Colaris M, van der Hulst R, Cohen Tervaert JW (2017) Is explantation of silicone breast implants useful in patients with complaints? Immunol Res 65(1):25–36. https://doi.org/10.1007/s12026-016-8813-y
doi: 10.1007/s12026-016-8813-y
pubmed: 27412295
Singh N, Picha GJ, Hardas B, Schumacher A, Murphy DK (2017) Five-year safety data for more than 55,000 subjects following breast implantation: comparison of rare adverse event rates with silicone implants versus national norms and saline implants. Plast Reconstr Surg 140(4):666–679. https://doi.org/10.1097/PRS.0000000000003711
doi: 10.1097/PRS.0000000000003711
pubmed: 28953716
Watad A, Rosenberg V, Tiosano S, Cohen Tervaert JW, Yavne Y, Shoenfeld Y, Shalev V, Chodick G, Amital H (2018) Silicone breast implants and the risk of autoimmune/rheumatic disorders: a real-world analysis. Int J Epidemiol 47(6):1846–1854. https://doi.org/10.1093/ije/dyy217
doi: 10.1093/ije/dyy217
pubmed: 30329056
Coroneos CJ, Selber JC, Offodile AC 2nd, Butler CE, Clemens MW (2019) US FDA breast implant postapproval studies: long-term outcomes in 99,993 patients. Ann Surg 269(1):30–36. https://doi.org/10.1097/SLA.0000000000002990
doi: 10.1097/SLA.0000000000002990
pubmed: 30222598
Vera-Lastra O, Cruz-Dominguez MP, MedradoRamírez G, Medina G, Amigo MC, Peralta-Amaro AL et al (2019) Autoimmune/inflammatory syndrome induced by silicone breast implant and risk factors associated to autoimmune diseases. Rheumatology (Sunnyvale) 9(1):1000248. https://doi.org/10.35248/2161-1149.19.9.248
doi: 10.35248/2161-1149.19.9.248
Young VL, Nemecek JR, Schwartz BD, Phelan DL, Schorr MW (1995) HLA typing in women with breast implants. Plast Reconstr Surg 96(7):1497–1520
doi: 10.1097/00006534-199512000-00001
Borba V, Malkova A, Basantsova N, Halpert G, Andreoli L, Tincani A, Amital H, Shoenfeld Y (2020) Classical examples of the concept of the ASIA syndrome. Biomolecules 10(1436):1–16. https://doi.org/10.3390/biom10101436
doi: 10.3390/biom10101436
Shoenfeld Y, Ryabkova VA, Scheibenbogen C, Brinth L, Martinez-Lavin M, Ikeda S, Heidecke H, Watad A, Bragazzi NL, Chapman J, Churilov LP, Amital H (2020) Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. Clin Immunol (Orlando Fla) 214:108384. https://doi.org/10.1016/j.clim.2020.108384
doi: 10.1016/j.clim.2020.108384
Woźniak-Roszkowska E, Maślińska M, Gierej P, Noszczyk B (2020) Autoimmune syndrome induced by adjuvants after breast enhancement with polyacrylamide hydrogel: a study in Poland. Rheumatol Int 40(11):1851–1856. https://doi.org/10.1007/s00296-020-04605-5
doi: 10.1007/s00296-020-04605-5
pubmed: 32449041
pmcid: 7519915
Slight-Webb S, Smith M, Bylinska A, Macwana S, Guthridge C, Lu R, Merrill JT, Chakravarty E, Arriens C, Munroe ME, Maecker HT, Utz PJ, Guthridge JM, James JA (2020) Autoantibody-positive healthy individuals with lower lupus risk display a unique immune endotype. J Allergy Clin Immunol 146(6):1419–1433. https://doi.org/10.1016/j.jaci.2020.04.047
doi: 10.1016/j.jaci.2020.04.047
pubmed: 32446964
pmcid: 7680268
Slight-Webb S, Lu R, Ritterhouse LL, Munroe ME, Maecker HT, Fathman CG, Utz PJ, Merrill JT, Guthridge JM, James JA (2016) Autoantibody-positive healthy individuals display unique immune profiles that may regulate autoimmunity. Arthritis Rheumatol (Hoboken NJ) 68(10):2492–2502. https://doi.org/10.1002/art.39706
doi: 10.1002/art.39706
Mariz HA, Sato EI, Barbosa SH, Rodrigues SH, Dellavance A, Andrade LE (2011) Pattern on the antinuclear antibody-HEp-2 test is a critical parameter for discriminating antinuclear antibody-positive healthy individuals and patients with autoimmune rheumatic diseases. Arthritis Rheum 63(1):191–200. https://doi.org/10.1002/art.30084
doi: 10.1002/art.30084
pubmed: 20954189
www.fda.gov/medical-devices/breast-implants/medical-device-reports-systemic-symptoms-women-breast-implants (2020)