Interleukin 24 promotes cell death in renal epithelial cells and is associated with acute renal injury.
basic (laboratory) research/science
kidney (allograft) function/dysfunction
kidney disease: immune/inflammatory
kidney transplantation/nephrology
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
02
06
2022
received:
23
01
2022
accepted:
03
07
2022
pubmed:
9
7
2022
medline:
10
11
2022
entrez:
8
7
2022
Statut:
ppublish
Résumé
Ischemia-reperfusion injury is a major cause of acute kidney injury. Many cytokines are involved in the pathogenesis of renal ischemia-reperfusion injury. IL24 is a member of the IL10 family and has gained importance because of its apoptosis-inducing effects in tumor disease besides its immunoregulative function. Littles is known about the role of IL24 in kidney disease. Using a mouse model, we found that IL24 is upregulated in the kidney after renal ischemia-reperfusion injury and that tubular epithelial cells and infiltrating inflammatory cells are the source of IL24. Mice lacking IL24 are protected from renal injury and inflammation. Cell culture studies showed that IL24 induces apoptosis in renal tubular epithelial cells, which is accompanied by an increased endoplasmatic reticulum stress response. Moreover, IL24 induces robust expression of endogenous IL24 in tubular cells, fostering ER-stress and apoptosis. In kidney transplant recipients with delayed graft function and patients at high risk to develop acute kidney injury after cardiac surgery IL24 is upregulated in the kidney and serum. Taken together, IL24 can serve as a biomarker, plays an important mechanistic role involving both extracellular and intracellular targets, and is a promising therapeutic target in patients at risk of or with ischemia-induced acute kidney injury.
Identifiants
pubmed: 35801504
doi: 10.1111/ajt.17143
pii: S1600-6135(22)29971-7
doi:
Substances chimiques
Interleukins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2548-2559Informations de copyright
© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
Références
Chawla LS, Eggers PW, Star RA, Kimmel PL. Acute kidney injury and chronic kidney disease as interconnected syndromes. N Engl J Med. 2014;371(1):58-66.
Mohsenin V. Practical approach to detection and management of acute kidney injury in critically ill patient. J Intens Care. 2017;5:57.
Coca SG, Singanamala S, Parikh CR. Chronic kidney disease after acute kidney injury: a systematic review and meta-analysis. Kidney Int. 2012;81(5):442-448.
Kentrup D, Reuter S, Schnöckel U, et al. Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury. PLoS One. 2011;6(10):e26419.
Mahfoudh-Boussaid A, Zaouali MA, Hauet T, et al. Attenuation of endoplasmic reticulum stress and mitochondrial injury in kidney with ischemic postconditioning application and trimetazidine treatment. J Biomed Sci. 2012;19:71.
Salvadori M, Rosso G, Bertoni E. Update on ischemia-reperfusion injury in kidney transplantation: pathogenesis and treatment. World J Transplant. 2015;5(2):52-67.
Baek J-H, Zeng R, Weinmann-Menke J, et al. IL-34 mediates acute kidney injury and worsens subsequent chronic kidney disease. J Clin Invest. 2015;125(8):3198-3214.
Kulkarni OP, Hartter I, Mulay SR, et al. Toll-like receptor 4-induced IL-22 accelerates kidney regeneration. J Am Soc Nephrol. 2014;25(5):978-989.
Xu M-J, Feng D, Wang H, Guan Y, Yan X, Gao B. IL-22 ameliorates renal ischemia-reperfusion injury by targeting proximal tubule epithelium. J Am Soc Nephrol. 2014;25(5):967-977.
Melnikov VY, Ecder T, Fantuzzi G, et al. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest. 2001;107(9):1145-1152.
Liu KD, Altmann C, Smits G, et al. Serum interleukin-6 and interleukin-8 are early biomarkers of acute kidney injury and predict prolonged mechanical ventilation in children undergoing cardiac surgery: a case-control study. Crit Care. 2009;13(4):R104.
Chen J, Hartono JR, John R, et al. Early interleukin 6 production by leukocytes during ischemic acute kidney injury is regulated by TLR4. Kidney Int. 2011;80(5):504-515.
Jiang H, Lin JJ, Su ZZ, Goldstein NI, Fisher PB. Subtraction hybridization identifies a novel melanoma differentiation associated gene, mda-7, modulated during human melanoma differentiation, growth and progression. Oncogene. 1995;11(12):2477-2486.
Buzas K, Oppenheim JJ, Zack Howard OM. Myeloid cells migrate in response to IL-24. Cytokine. 2011;55(3):429-434.
Wahl C, Müller W, Leithäuser F, et al. IL-20 receptor 2 signaling down-regulates antigen-specific T cell responses. J Immunol. 2009;182(2):802-810.
Wang M, Tan Z, Zhang R, Kotenko SV, Liang P. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J Biol Chem. 2002;277(9):7341-7347.
Hsu Y-H, Li H-H, Sung J-M, Chen W-T, Hou Y-C, Chang M-S. Interleukin-19 mediates tissue damage in murine ischemic acute kidney injury. PLoS One. 2013;8(2):e56028.
Wei C-C, Li H-H, Hsu Y-H, Hsing C-H, Sung J-M, Chang M-S. Interleukin-20 targets renal cells and is associated with chronic kidney disease. Biochem Biophys Res Commun. 2008;374(3):448-453.
Pap D, Veres-Székely A, Szebeni B, et al. Characterization of IL-19, −20, and −24 in acute and chronic kidney diseases reveals a pro-fibrotic role of IL-24. J Transl Med. 2020;18(1):172.
Tabata T, Sugiyama N, Otsuki Y, Kondo Y. Interleukin-24 is a novel diagnostic biomarker for the severity of acute kidney injury. Med Mol Morphol. 2020;53(2):115-123.
Wang M, Liang P. Interleukin-24 and its receptors. Immunology. 2005;114(2):166-170.
Persaud L, de Jesus D, Brannigan O, et al. Mechanism of action and applications of interleukin 24 in immunotherapy. Int J Mol Sci. 2016;17(6):869.
Menezes ME, Bhoopathi P, Pradhan AK, et al. Role of MDA-7/IL-24 a multifunction protein in human diseases. Adv Cancer Res. 2018;138:143-182.
Nagalakshmi ML, Murphy E, McClanahan T, de Waal Malefyt R. Expression patterns of IL-10 ligand and receptor gene families provide leads for biological characterization. Int Immunopharmacol. 2004;4(5):577-592.
Ma Y, Chen H-D, Wang Y, et al. Interleukin 24 as a novel potential cytokine immunotherapy for the treatment of mycobacterium tuberculosis infection. Microbes Infect. 2011;13(12-13):1099-1110.
He M, Liang P. IL-24 transgenic mice: in vivo evidence of overlapping functions for IL-20, IL-22, and IL-24 in the epidermis. J Immunol. 2010;184(4):1793-1798.
Menezes ME, Bhatia S, Bhoopathi P, et al. MDA-7/IL-24: multifunctional cancer killing cytokine. Adv Exp Med Biol. 2014;818:127-153.
Lebedeva IV, Sauane M, Gopalkrishnan RV, et al. Mda-7/IL-24: exploiting cancer's Achilles' heel. Mol Ther. 2005;11(1):4-18.
Sauane M, Su Z-Z, Gupta P, et al. Autocrine regulation of mda-7/IL-24 mediates cancer-specific apoptosis. Proc Natl Acad Sci USA. 2008;105(28):9763-9768.
Schütte-Nütgen K, Edeling M, Mendl G, et al. Getting a notch closer to renal dysfunction: activated notch suppresses expression of the adaptor protein Disabled-2 in tubular epithelial cells. FASEB J. 2019;33(1):821-832.
Di Marco GS, Reuter S, Kentrup D, et al. Treatment of established left ventricular hypertrophy with fibroblast growth factor receptor blockade in an animal model of CKD. Nephrol Dial Transplant. 2014;29(11):2028-2035.
Zarbock A, Schmidt C, van Aken H, et al. Effect of remote ischemic preconditioning on kidney injury among high-risk patients undergoing cardiac surgery: a randomized clinical trial. Jama. 2015;313(21):2133-2141.
Schulze U, Vollenbröker B, Braun DA, et al. The Vac14-interaction network is linked to regulators of the endolysosomal and autophagic pathway. Mol Cell Proteom. 2014;13(6):1397-1411.
Taketani S, Kohno H, Tokunaga R. Expression and phosphorylation of transferrin receptors in mitogen-activated peripheral blood lymphocytes. J Biochem. 1985;98(6):1639-1646.
Mishra J, Ma Q, Prada A, et al. Identification of neutrophil gelatinase-associated lipocalin as a novel early urinary biomarker for ischemic renal injury. J Am Soc Nephrol. 2003;14(10):2534-2543.
Li H-H, Hsu Y-H, Wei C-C, Lee P-T, Chen W-C, Chang M-S. Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure. Genes Immun. 2008;9(5):395-404.
Jordan WJ, Eskdale J, Boniotto M, et al. Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10. Eur J Immunol. 2005;35(5):1576-1582.
Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol. 2001;167(7):3545-3549.
Hsu T, Möröy T, Etiemble J, et al. Activation of c-myc by woodchuck hepatitis virus insertion in hepatocellular carcinoma. Cell. 1988;55(4):627-635.
Coca SG, Yusuf B, Shlipak MG, Garg AX, Parikh CR. Long-term risk of mortality and other adverse outcomes after acute kidney injury: a systematic review and meta-analysis. Am J Kidney Dis. 2009;53(6):961-973.
Lo LJ, Go AS, Chertow GM, et al. Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease. Kidney Int. 2009;76(8):893-899.
Chawla LS, Amdur RL, Amodeo S, Kimmel PL, Palant CE. The severity of acute kidney injury predicts progression to chronic kidney disease. Kidney Int. 2011;79(12):1361-1369.
Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11(4):381-389.
Yan M, Shu S, Guo C, Tang C, Dong Z. Endoplasmic reticulum stress in ischemic and nephrotoxic acute kidney injury. Ann Med. 2018;50(5):381-390.
Do W, Herrera C, Mighty J, Shumskaya M, Redenti SM, Sauane M. Sigma 1 receptor plays a prominent role in IL-24-induced cancer-specific apoptosis. Biochem Biophys Res Commun. 2013;439(2):215-220.
Ortega-Roldan JL, Ossa F, Schnell JR. Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions. J Biol Chem. 2013;288(29):21448-21457.
Hosszu A, Antal Z, Lenart L, et al. σ1-receptor agonism protects against renal ischemia-reperfusion injury. J Am Soc Nephrol. 2017;28(1):152-165.
Hasnain SZ, Borg DJ, Harcourt BE, et al. Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nat Med. 2014;20(12):1417-1426.
Wang J, Hu B, Zhao Z, et al. Intracellular XBP1-IL-24 axis dismantles cytotoxic unfolded protein response in the liver. Cell Death Dis. 2020;11(1):17.
Inagi R. Endoplasmic reticulum stress as a progression factor for kidney injury. Curr Opin Pharmacol. 2010;10(2):156-165.
Iurlaro R, Muñoz-Pinedo C. Cell death induced by endoplasmic reticulum stress. FEBS J. 2016;283(14):2640-2652.