Variability of endogenous deoxyribonuclease activity and its pathophysiological consequences.
Cell-free DNA
DAMPs
Deoxyribonuclease
Mitochondrial DNA
Toll-like receptor 9
Journal
Molecular and cellular probes
ISSN: 1096-1194
Titre abrégé: Mol Cell Probes
Pays: England
ID NLM: 8709751
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
01
06
2022
revised:
01
07
2022
accepted:
01
07
2022
pubmed:
9
7
2022
medline:
9
9
2022
entrez:
8
7
2022
Statut:
ppublish
Résumé
Deoxyribonucleases (DNases) are enzymes that cleave DNA. Some DNases are secreted outside of cells where they can cleave extracellular DNA (ecDNA). High concentration of ecDNA is associated with diseases such as sepsis, preeclampsia, and systemic lupus. DNA can be released from dying cells and is immunogenic. DNases cleave ecDNA and might prevent activation of the immune system. Low DNase activity could be disadvantageous in diseases where high amounts of ecDNA are released from dying cells. The relationship between DNase activity and ecDNA remains unknown. The lack of standard values in DNase activity makes the studies difficult to compare. This review focuses on summarizing methods for DNase activity measurements, the possible implication of decreased DNase activity in diseases, and the impact on diseases associated with a high concentration of ecDNA.
Identifiants
pubmed: 35803442
pii: S0890-8508(22)00055-X
doi: 10.1016/j.mcp.2022.101844
pii:
doi:
Substances chimiques
DNA
9007-49-2
Deoxyribonucleases
EC 3.1.-
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101844Informations de copyright
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