Volatilomic Signatures of AGS and SNU-1 Gastric Cancer Cell Lines.
AGS
GC-MS
GES-1
SNU-1
chemical footprint
gastric cancer
volatile organic compounds
volatilome
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
22 Jun 2022
22 Jun 2022
Historique:
received:
17
05
2022
revised:
18
06
2022
accepted:
18
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
In vitro studies can help reveal the biochemical pathways underlying the origin of volatile indicators of numerous diseases. The key objective of this study is to identify the potential biomarkers of gastric cancer. For this purpose, the volatilomic signatures of two human gastric cancer cell lines, AGS (human gastric adenocarcinoma) and SNU-1 (human gastric carcinoma), and one normal gastric mucosa cell line (GES-1) were investigated. More specifically, gas chromatography mass spectrometry has been applied to pinpoint changes in cell metabolism triggered by cancer. In total, ten volatiles were found to be metabolized, and thirty-five were produced by cells under study. The volatiles consumed were mainly six aldehydes and two heterocyclics, whereas the volatiles released embraced twelve ketones, eight alcohols, six hydrocarbons, three esters, three ethers, and three aromatic compounds. The SNU-1 cell line was found to have significantly altered metabolism in comparison to normal GES-1 cells. This was manifested by the decreased production of alcohols and ketones and the upregulated emission of esters. The AGS cells exhibited the increased production of methyl ketones containing an odd number of carbons, namely 2-tridecanone, 2-pentadecanone, and 2-heptadecanone. This study provides evidence that the cancer state modifies the volatilome of human cells.
Identifiants
pubmed: 35807254
pii: molecules27134012
doi: 10.3390/molecules27134012
pmc: PMC9268292
pii:
doi:
Substances chimiques
Alcohols
0
Esters
0
Ketones
0
Volatile Organic Compounds
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Union
ID : 824986
Organisme : National Science Centre, Poland
ID : 2021/41/N/ST4/02307
Références
Theranostics. 2014 Jan 05;4(2):154-62
pubmed: 24465273
Gastric Cancer. 2019 Nov;22(6):1193-1203
pubmed: 31111275
J Breath Res. 2018 Jul 30;12(4):046005
pubmed: 29893713
Chem Biol Interact. 2005 Feb 10;151(3):203-11
pubmed: 15733541
Cancer Cell Int. 2013 Jul 17;13(1):72
pubmed: 23870484
BMC Cancer. 2016 Jul 07;16:400
pubmed: 27388016
Biosensors (Basel). 2020 Jul 25;10(8):
pubmed: 32722438
Nephrol Dial Transplant. 2004 Oct;19(10):2576-83
pubmed: 15280519
Free Radic Biol Med. 2000 Mar 15;28(6):880-6
pubmed: 10802218
Clin Chim Acta. 2008 Sep;395(1-2):1-5
pubmed: 18505683
Dig Dis Sci. 2008 Aug;53(8):2101-5
pubmed: 18231859
Front Mol Biosci. 2021 Jan 11;7:607904
pubmed: 33585559
Br J Surg. 2019 Aug;106(9):1122-1125
pubmed: 31259390
Int J Oncol. 2016 Aug;49(2):611-22
pubmed: 27279633
Metabolomics. 2018 Apr 17;14(5):62
pubmed: 30830384
Sci Rep. 2018 Apr 3;8(1):5539
pubmed: 29615722
Sci Rep. 2017 Mar 03;7:43969
pubmed: 28256598
Clin Chim Acta. 2001 Apr;306(1-2):51-61
pubmed: 11282094
ScientificWorldJournal. 2014;2014:215783
pubmed: 25143966
Chem Res Toxicol. 2013 Jan 18;26(1):6-25
pubmed: 23061605
Nucleic Acids Res. 2021 Jan 8;49(D1):D1074-D1082
pubmed: 33219674
Food Chem Toxicol. 2017 Feb;100:217-224
pubmed: 28007454
J Biomol Tech. 2018 Jul;29(2):25-38
pubmed: 29805321
J Breath Res. 2015 Feb 10;9(2):027103
pubmed: 25667342
Curr Med Chem. 2016;23(20):2112-31
pubmed: 27160536
PeerJ. 2021 Apr 16;9:e11146
pubmed: 33959414
J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Dec 1;1006:158-166
pubmed: 26551208
J Breath Res. 2020 Nov 19;15(1):
pubmed: 33105106
Cancer. 2021 Apr 15;127(8):1286-1292
pubmed: 33739456
ACS Nano. 2017 Jan 24;11(1):112-125
pubmed: 28000444
Free Radic Biol Med. 1994 Aug;17(2):127-60
pubmed: 7959173
Hoppe Seylers Z Physiol Chem. 1970 Aug;351(8):903-12
pubmed: 4393760
Biochemistry. 1984 Dec 18;23(26):6363-8
pubmed: 6397223
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jul 15;931:90-6
pubmed: 23770738
Anticancer Res. 2009 Jan;29(1):419-26
pubmed: 19331181
Chemosphere. 2010 Dec;81(11):1544-8
pubmed: 20822795
J Biomed Biotechnol. 2012;2012:891961
pubmed: 22919278
Cancer Epidemiol Biomarkers Prev. 2010 Jan;19(1):182-95
pubmed: 20056637
Chem Rev. 2010 Feb 10;110(2):932-48
pubmed: 19769330
Br J Cancer. 2013 Mar 5;108(4):941-50
pubmed: 23462808
Proc Nutr Soc. 2004 Feb;63(1):49-63
pubmed: 15099407
World J Exp Med. 2015 May 20;5(2):84-102
pubmed: 25992323
Chem Res Toxicol. 2020 Feb 17;33(2):669-677
pubmed: 31957442
J Chromatogr Sci. 2006 Aug;44(7):387-93
pubmed: 16925936
Toxicol Lett. 2001 Oct 15;124(1-3):37-45
pubmed: 11684356
Analyst. 2012 Jul 21;137(14):3278-85
pubmed: 22662321
Cancer Biomark. 2012;11(4):129-37
pubmed: 23144150
J Chromatogr B Analyt Technol Biomed Life Sci. 2019 Jan 1;1104:256-261
pubmed: 30537625
World J Gastroenterol. 2016 Feb 28;22(8):2460-74
pubmed: 26937134
Biochemistry. 1996 Apr 9;35(14):4457-67
pubmed: 8605195
Int J Oncol. 2013 Apr;42(4):1437-42
pubmed: 23440340
J Breath Res. 2016 Sep 28;10(4):047101
pubmed: 27677863
Front Mol Biosci. 2020 Jun 30;7:116
pubmed: 32695794
Cell Biochem Biophys. 2015 Jan;71(1):323-9
pubmed: 25123840
J Biomed Biotechnol. 2011;2011:603925
pubmed: 21188172