The Therapeutic Potential of Kaemferol and Other Naturally Occurring Polyphenols Might Be Modulated by Nrf2-ARE Signaling Pathway: Current Status and Future Direction.
Nrf2 modulation
kaempferol
targeting Nrf2 modulation
therapeutic outcomes
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
28 Jun 2022
28 Jun 2022
Historique:
received:
21
04
2022
revised:
13
06
2022
accepted:
20
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Kaempferol is a natural flavonoid, which has been widely investigated in the treatment of cancer, cardiovascular diseases, metabolic complications, and neurological disorders. Nrf2 (nuclear factor erythroid 2-related factor 2) is a transcription factor involved in mediating carcinogenesis and other ailments, playing an important role in regulating oxidative stress. The activation of Nrf2 results in the expression of proteins and cytoprotective enzymes, which provide cellular protection against reactive oxygen species. Phytochemicals, either alone or in combination, have been used to modulate Nrf2 in cancer and other ailments. Among them, kaempferol has been recently explored for its anti-cancer and other anti-disease therapeutic efficacy, targeting Nrf2 modulation. In combating cancer, diabetic complications, metabolic disorders, and neurological disorders, kaempferol has been shown to regulate Nrf2 and reduce redox homeostasis. In this context, this review article highlights the current status of the therapeutic potential of kaempferol by targeting Nrf2 modulation in cancer, diabetic complications, neurological disorders, and cardiovascular disorders. In addition, we provide future perspectives on kaempferol targeting Nrf2 modulation as a potential therapeutic approach.
Identifiants
pubmed: 35807387
pii: molecules27134145
doi: 10.3390/molecules27134145
pmc: PMC9268049
pii:
doi:
Substances chimiques
Kaempferols
0
NF-E2-Related Factor 2
0
Polyphenols
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Med Res Rev. 2012 Jul;32(4):687-726
pubmed: 22549716
Int Immunopharmacol. 2017 Feb;43:236-242
pubmed: 28043032
J Steroid Biochem Mol Biol. 2014 Sep;143:11-8
pubmed: 24486718
Cell Death Discov. 2021 Jul 26;7(1):193
pubmed: 34312370
Biopharm Drug Dispos. 2015 Oct;36(7):440-51
pubmed: 25904312
Med Sci Monit. 2016 Dec 08;22:4803-4808
pubmed: 27928147
Int J Mol Sci. 2021 Apr 22;22(9):
pubmed: 33922165
Mol Carcinog. 2013 Oct;52(10):824-34
pubmed: 22593043
JCI Insight. 2018 Mar 8;3(5):
pubmed: 29515034
Braz J Med Biol Res. 2019 Feb 14;52(2):e7843
pubmed: 30785478
Hepatology. 2016 Jan;63(1):173-84
pubmed: 26403645
Pharmacol Res. 2018 Aug;134:92-99
pubmed: 29913224
J Nutr Biochem. 2021 Jul;93:108634
pubmed: 33794330
Food Chem Toxicol. 2015 Aug;82:19-26
pubmed: 25957741
Aging Dis. 2019 Jun 01;10(3):637-651
pubmed: 31165007
Cardiovasc Toxicol. 2019 Feb;19(1):23-35
pubmed: 29968071
Neurochem Int. 2011 Feb;58(2):153-60
pubmed: 21093515
J AOAC Int. 2019 Sep 1;102(5):1397-1400
pubmed: 31200785
Molecules. 2021 Mar 01;26(5):
pubmed: 33804548
Cell. 2019 Jul 11;178(2):316-329.e18
pubmed: 31257023
J Cardiovasc Pharmacol. 2019 Oct;74(4):326-335
pubmed: 31356553
Free Radic Biol Med. 2021 May 20;168:129-141
pubmed: 33794311
Drug Dev Res. 2019 May;80(3):294-309
pubmed: 30864233
Oncogene. 2013 Oct;32(40):4825-35
pubmed: 23108405
Cancers (Basel). 2018 Dec 03;10(12):
pubmed: 30513925
Int Immunopharmacol. 2019 Dec;77:105951
pubmed: 31634788
J Physiol Pharmacol. 2021 Jun;72(3):
pubmed: 34810287
Int J Mol Sci. 2019 Jan 24;20(3):
pubmed: 30678325
Can J Physiol Pharmacol. 2017 Mar;95(3):260-267
pubmed: 28177689
Life Sci. 2020 Aug 15;255:117481
pubmed: 32135183
J Cell Physiol. 2020 Nov;235(11):7696-7708
pubmed: 32324275
RSC Adv. 2018 Jan 10;8(5):2280-2292
pubmed: 35541453
J BUON. 2019 Jul-Aug;24(4):1555-1561
pubmed: 31646808
Biology (Basel). 2020 Sep 21;9(9):
pubmed: 32967203
Antioxidants (Basel). 2020 Feb 25;9(3):
pubmed: 32106613
Biochim Biophys Acta. 2008 Oct;1783(10):1847-56
pubmed: 18585411
Cell Death Dis. 2020 Aug 20;11(8):663
pubmed: 32814771
Eur J Pharmacol. 2019 Jan 15;843:12-26
pubmed: 30359563
Semin Cancer Biol. 2021 Nov;76:110-119
pubmed: 34020028
Molecules. 2020 Nov 23;25(22):
pubmed: 33238435
Cell Mol Biol Lett. 2014 Sep;19(3):500-16
pubmed: 25169438
Mol Cell Biochem. 2021 Feb;476(2):525-533
pubmed: 33064289
Antioxidants (Basel). 2021 Nov 23;10(12):
pubmed: 34942962
Int J Mol Sci. 2021 Jul 26;22(15):
pubmed: 34360732
Cancer Prev Res (Phila). 2019 Mar;12(3):135-146
pubmed: 30651293
Foods. 2021 Sep 08;10(9):
pubmed: 34574234
Neurosci Lett. 2020 Jan 18;716:134633
pubmed: 31743752
Oxid Med Cell Longev. 2019 Apr 11;2019:8592348
pubmed: 31097977
J Nutr Biochem. 2019 Dec;74:108228
pubmed: 31678747
Toxicol Lett. 2019 May 15;306:53-60
pubmed: 30769083
Front Pharmacol. 2020 Jul 22;11:1118
pubmed: 32792954
Neurochem Res. 2020 Feb;45(2):295-309
pubmed: 31768814
Oncotarget. 2016 Nov 8;7(45):73593-73606
pubmed: 27713154
FASEB J. 2013 Feb;27(2):414-23
pubmed: 23109674
Redox Biol. 2017 Aug;12:311-324
pubmed: 28285192
Front Mol Neurosci. 2018 Oct 04;11:310
pubmed: 30337853
Med Sci Monit. 2017 Aug 14;23:3925-3931
pubmed: 28806392
Adv Food Nutr Res. 2019;90:183-257
pubmed: 31445596
Curr Pharmacol Rep. 2019;5(4):255-280
pubmed: 32226726
Arch Biochem Biophys. 2021 Jan 15;697:108700
pubmed: 33271149
Biomed Rep. 2018 May;8(5):461-465
pubmed: 29732149
Oxid Med Cell Longev. 2019 Jul 14;2019:9372182
pubmed: 31396308
Toxicol In Vitro. 2020 Jun;65:104799
pubmed: 32070777
Trends Endocrinol Metab. 2021 Jan;32(1):7-19
pubmed: 33243626
Pestic Biochem Physiol. 2018 Nov;152:29-37
pubmed: 30497708
Nutr Cancer. 2022;74(3):996-1011
pubmed: 34120541
Int J Mol Sci. 2022 Mar 05;23(5):
pubmed: 35269986
Anal Cell Pathol (Amst). 2019 Dec 1;2019:1907698
pubmed: 31871879
Drug Des Devel Ther. 2019 Oct 07;13:3497-3514
pubmed: 31631974
Oxid Med Cell Longev. 2017;2017:9237263
pubmed: 29104732
Arch Physiol Biochem. 2021 Feb 24;:1-14
pubmed: 33625930
Cell Death Dis. 2018 Jan 11;9(1):15
pubmed: 29323103
Cancers (Basel). 2019 Nov 08;11(11):
pubmed: 31717324
Carcinogenesis. 2020 Jun 17;41(4):405-416
pubmed: 32347301
Biochem Biophys Res Commun. 2011 Apr 29;408(1):1-5
pubmed: 21439933
Toxicology. 2020 Jan 15;429:152338
pubmed: 31785310
Br J Nutr. 2013 Dec;110(12):2138-49
pubmed: 23769299
Pharmacol Res. 2022 Jan;175:106005
pubmed: 34843960
Cell Biochem Funct. 2017 Dec;35(8):518-526
pubmed: 29214656
Phytother Res. 2019 Feb;33(2):263-275
pubmed: 30402931
Int Immunopharmacol. 2012 Oct;14(2):209-16
pubmed: 22835426
Biomed Pharmacother. 2022 Jan;145:112395
pubmed: 34775239
Antioxidants (Basel). 2021 Sep 05;10(9):
pubmed: 34573051
Nat Rev Cardiol. 2021 Feb;18(2):117-135
pubmed: 32999450
Pharmaceutics. 2022 Apr 18;14(4):
pubmed: 35456721
Mol Biol Rep. 2021 Feb;48(2):1745-1761
pubmed: 33515348
Int J Mol Sci. 2021 Jul 30;22(15):
pubmed: 34360990
Pharm Biol. 2021 Dec;59(1):1106-1116
pubmed: 34403325
J Nutr Biochem. 2016 Jul;33:54-62
pubmed: 27260468
Int J Mol Sci. 2017 May 15;18(5):
pubmed: 28505121
Biomed Res Int. 2020 Oct 21;2020:5891016
pubmed: 33145355
Ann N Y Acad Sci. 2017 Aug;1401(1):114-135
pubmed: 28662306
Food Chem Toxicol. 2014 Oct;72:303-11
pubmed: 25111660
Arch Biochem Biophys. 2015 Jan 15;566:76-84
pubmed: 25528168
J Biochem. 2022 May 11;171(5):567-578
pubmed: 35137113
Biofactors. 2018 Jan;44(1):36-49
pubmed: 29193412
Int Immunopharmacol. 2015 Sep;28(1):328-36
pubmed: 26122134
Food Chem. 2013 Nov 1;141(1):313-9
pubmed: 23768363
Oxid Med Cell Longev. 2022 Mar 23;2022:7848811
pubmed: 35368867
Dig Dis Sci. 2012 Feb;57(2):355-63
pubmed: 21901258
Biomol Ther (Seoul). 2018 Jan 1;26(1):57-68
pubmed: 29212307
Antioxid Redox Signal. 2017 Oct 1;27(10):684-712
pubmed: 28398072
Metab Brain Dis. 2019 Apr;34(2):485-494
pubmed: 30762138
Cardiovasc Toxicol. 2018 Feb;18(1):1-8
pubmed: 28389765
Exp Ther Med. 2019 Oct;18(4):2759-2776
pubmed: 31572524