Very low birth weight newborn with diabetes mellitus due to pancreas agenesis managed with insulin pump reservoir filled with undiluted insulin: 16-month follow-up.
Diabetes in infancy
Hybrid closed loop systems
Insulin dilution
Insulin pump
Neonatal diabetes mellitus
Journal
Diabetes & metabolic syndrome
ISSN: 1878-0334
Titre abrégé: Diabetes Metab Syndr
Pays: Netherlands
ID NLM: 101462250
Informations de publication
Date de publication:
Jul 2022
Jul 2022
Historique:
received:
19
04
2022
revised:
27
05
2022
accepted:
27
06
2022
pubmed:
10
7
2022
medline:
5
8
2022
entrez:
9
7
2022
Statut:
ppublish
Résumé
When very low doses of insulin are used insulin dilution, a procedure prone to errors, is recommended. We managed a neonate with pancreas agenesis with insulin pump therapy from the first days of life to 16 months of age without insulin dilution. Predictive low glucose suspend mode first and then closed loop control were used. No episodes of severe hypoglycemia were observed. Though limited to a single patient with pancreas agenesis we believe that the use of pump should be warranted in patients with permanent neonatal diabetes mellitus and intestinal malabsorption, even with undiluted insulin.
Sections du résumé
BACKGROUND
BACKGROUND
When very low doses of insulin are used insulin dilution, a procedure prone to errors, is recommended.
CASE PRESENTATION
METHODS
We managed a neonate with pancreas agenesis with insulin pump therapy from the first days of life to 16 months of age without insulin dilution. Predictive low glucose suspend mode first and then closed loop control were used. No episodes of severe hypoglycemia were observed.
CONCLUSIONS
CONCLUSIONS
Though limited to a single patient with pancreas agenesis we believe that the use of pump should be warranted in patients with permanent neonatal diabetes mellitus and intestinal malabsorption, even with undiluted insulin.
Identifiants
pubmed: 35809554
pii: S1871-4021(22)00175-8
doi: 10.1016/j.dsx.2022.102561
pii:
doi:
Substances chimiques
Blood Glucose
0
Hypoglycemic Agents
0
Insulin
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
102561Informations de copyright
Copyright © 2022 Diabetes India. Published by Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest A.Z., A.P., S.C., R. S., A.S.R., E.M.G., F.B. and D.I. have no financial or other relationships that could lead to a conflict of interest. V.T. is an employee of Medtronic.