Motor learning selectively strengthens cortical and striatal synapses of motor engram neurons.
corticostriatal circuit
dendritic spines
memory engram
motor learning
synaptic clustering
synaptic plasticity
two-photon imaging
Journal
Neuron
ISSN: 1097-4199
Titre abrégé: Neuron
Pays: United States
ID NLM: 8809320
Informations de publication
Date de publication:
07 09 2022
07 09 2022
Historique:
received:
26
10
2021
revised:
21
03
2022
accepted:
07
06
2022
pubmed:
10
7
2022
medline:
14
9
2022
entrez:
9
7
2022
Statut:
ppublish
Résumé
Learning and consolidation of new motor skills require plasticity in the motor cortex and striatum, two key motor regions of the brain. However, how neurons undergo synaptic changes and become recruited during motor learning to form a memory engram remains unknown. Here, we train mice on a motor learning task and use a genetic approach to identify and manipulate behavior-relevant neurons selectively in the primary motor cortex (M1). We find that the degree of M1 engram neuron reactivation correlates with motor performance. We further demonstrate that learning-induced dendritic spine reorganization specifically occurs in these M1 engram neurons. In addition, we find that motor learning leads to an increase in the strength of M1 engram neuron outputs onto striatal spiny projection neurons (SPNs) and that these synapses form clusters along SPN dendrites. These results identify a highly specific synaptic plasticity during the formation of long-lasting motor memory traces in the corticostriatal circuit.
Identifiants
pubmed: 35809573
pii: S0896-6273(22)00544-X
doi: 10.1016/j.neuron.2022.06.006
pmc: PMC9464700
mid: NIHMS1817035
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2790-2801.e5Subventions
Organisme : NINDS NIH HHS
ID : R01 NS091144
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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