Historical perspective of tumor glycolysis: A century with Otto Warburg.
Aerobic glycolysis
Historical perspective
Reverse Warburg effect
Tumor metabolism
Warburg effect
Journal
Seminars in cancer biology
ISSN: 1096-3650
Titre abrégé: Semin Cancer Biol
Pays: England
ID NLM: 9010218
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
received:
10
05
2022
revised:
27
06
2022
accepted:
05
07
2022
pubmed:
10
7
2022
medline:
18
11
2022
entrez:
9
7
2022
Statut:
ppublish
Résumé
Tumors have long been known to rewire their metabolism to endorse their proliferation, growth, survival, and invasiveness. One of the common characteristics of these alterations is the enhanced glucose uptake and its subsequent transformation into lactic acid by means of glycolysis, regardless the availability of oxygen or the mitochondria effectiveness. This phenomenon is called the "Warburg effect", which has turned into a century of age now, since its first disclosure by German physiologist Otto Heinrich Warburg. Since then, this peculiar metabolic switch in tumors has been addressed by extensive studies covering several areas of research. In this historical perspective, we aim at illustrating the evolution of these studies over time and their implication in various fields of science.
Identifiants
pubmed: 35809880
pii: S1044-579X(22)00162-6
doi: 10.1016/j.semcancer.2022.07.003
pii:
doi:
Substances chimiques
Oxygen
S88TT14065
Lactic Acid
33X04XA5AT
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-333Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.