Fluid structure computational model of simulating mitral valve motion in a contracting left ventricle.

Chordae Tendineae Heart Valve Prosthesis Heart Ventricles Humans Mitral Valve Mitral Valve Insufficiency
Computational model Fluid structure interaction Left ventricle Mitral valve Regurgitation

Journal

Computers in biology and medicine
ISSN: 1879-0534
Titre abrégé: Comput Biol Med
Pays: United States
ID NLM: 1250250

Informations de publication

Date de publication:
09 2022
Historique:
received: 20 12 2021
revised: 24 06 2022
accepted: 04 07 2022
pubmed: 12 7 2022
medline: 31 8 2022
entrez: 11 7 2022
Statut: ppublish

Résumé

Fluid structure interaction simulations h hold promise in studying normal and abnormal cardiac function, including the effect of fluid dynamics on mitral valve (MV) leaflet motion. The goal of this study was to develop a 3D fluid structure interaction computational model to simulate bileaflet MV when interacting with blood motion in left ventricle (LV). The model consists of ideal geometric-shaped MV leaflets and the LV, with MV dimensions based on human anatomical measurements. An experimentally-based hyperelastic isotropic material was used to model the mechanical behaviour of the MV leaflets, with chordae tendineae and papillary muscle tips also incorporated. LV myocardial tissue was prescribed using a transverse isotropic hyperelastic formulation. Incompressible Navier-Stokes fluid formulations were used to govern the blood motion, and the Arbitrary Lagrangian Eulerian (ALE) method was employed to determine the mesh deformation of the fluid and solid domains due to trans-valvular pressure on MV boundaries and the resulting leaflet movement. The LV-MV generic model was able to reproduce physiological MV leaflet opening and closing profiles resulting from the time-varying atrial and ventricular pressures, as well as simulating normal and prolapsed MV states. Additionally, the model was able to simulate blood flow patterns after insertion of a prosthetic MV with and without left ventricular outflow tract flow obstruction. In the MV-LV normal model, the regurgitant blood flow fraction was 10.1 %, with no abnormality in cardiac function according to the mitral regurgitation severity grades reported by the American Society of Echocardiography. Our simulation approach provides insights into intraventricular fluid dynamics in a contracting LV with normal and prolapsed MV function, as well as aiding in the understanding of possible complications after transcatheter MV implantation prior to clinical trials.

Sections du résumé

BACKGROUND
Fluid structure interaction simulations h hold promise in studying normal and abnormal cardiac function, including the effect of fluid dynamics on mitral valve (MV) leaflet motion. The goal of this study was to develop a 3D fluid structure interaction computational model to simulate bileaflet MV when interacting with blood motion in left ventricle (LV).
METHODS
The model consists of ideal geometric-shaped MV leaflets and the LV, with MV dimensions based on human anatomical measurements. An experimentally-based hyperelastic isotropic material was used to model the mechanical behaviour of the MV leaflets, with chordae tendineae and papillary muscle tips also incorporated. LV myocardial tissue was prescribed using a transverse isotropic hyperelastic formulation. Incompressible Navier-Stokes fluid formulations were used to govern the blood motion, and the Arbitrary Lagrangian Eulerian (ALE) method was employed to determine the mesh deformation of the fluid and solid domains due to trans-valvular pressure on MV boundaries and the resulting leaflet movement.
RESULTS
The LV-MV generic model was able to reproduce physiological MV leaflet opening and closing profiles resulting from the time-varying atrial and ventricular pressures, as well as simulating normal and prolapsed MV states. Additionally, the model was able to simulate blood flow patterns after insertion of a prosthetic MV with and without left ventricular outflow tract flow obstruction. In the MV-LV normal model, the regurgitant blood flow fraction was 10.1 %, with no abnormality in cardiac function according to the mitral regurgitation severity grades reported by the American Society of Echocardiography.
CONCLUSION
Our simulation approach provides insights into intraventricular fluid dynamics in a contracting LV with normal and prolapsed MV function, as well as aiding in the understanding of possible complications after transcatheter MV implantation prior to clinical trials.

Identifiants

DOI: 10.1016/j.compbiomed.2022.105834 PMID: 35816854
pubmed: 35816854
pii: S0010-4825(22)00590-X
doi: 10.1016/j.compbiomed.2022.105834
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

105834

Informations de copyright

Copyright © 2022 Elsevier Ltd. All rights reserved.

Auteurs

Yousef Alharbi (Y)

College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia; Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. Electronic address: y.alharbi@psau.edu.sa.

Amr Al Abed (A)

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. Electronic address: amra@unsw.edu.au.

Azam Ahmad Bakir (AA)

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia; University of Southampton Malaysia Campus, Iskandar Puteri, Johor, Malaysia. Electronic address: a.ahmad-bakir@soton.ac.uk.

Nigel H Lovell (NH)

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. Electronic address: n.lovell@unsw.edu.au.

David W M Muller (DWM)

Victor Chang Cardiac Research Institute, Sydney, Australia; Department of Cardiology and Cardiothoracic Surgery, St Vincent's Hospital, Sydney, Australia. Electronic address: david.muller@svha.org.au.

James Otton (J)

Victor Chang Cardiac Research Institute, Sydney, Australia; Department of Cardiology, Liverpool Hospital, Sydney, Australia. Electronic address: j.otton@unsw.edu.au.

Socrates Dokos (S)

Graduate School of Biomedical Engineering, University of New South Wales, Sydney, Australia. Electronic address: s.dokos@unsw.edu.au.

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Classifications MeSH

questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Cordages tendineux › Fluid structure computational model of...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Prothèse valvulaire cardiaque › Fluid structure computational model of...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Ventricules cardiaques › Fluid structure computational model of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Fluid structure computational model of...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Valves cardiaques › Valve atrioventriculaire gauche › Fluid structure computational model of...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Valvulopathies › Insuffisance mitrale › Fluid structure computational model of...