Both Disease Activity and HLA-B27 Status Are Associated With Gut Microbiome Dysbiosis in Spondyloarthritis Patients.
Journal
Arthritis & rheumatology (Hoboken, N.J.)
ISSN: 2326-5205
Titre abrégé: Arthritis Rheumatol
Pays: United States
ID NLM: 101623795
Informations de publication
Date de publication:
01 2023
01 2023
Historique:
revised:
27
04
2022
received:
28
10
2021
accepted:
30
06
2022
pubmed:
13
7
2022
medline:
30
12
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
Gut microbiome dysbiosis has previously been reported in spondyloarthritis (SpA) patients and could be critically involved in the pathogenesis of this disorder. The objectives of this study were to further characterize the microbiota structure in SpA patients and to investigate the relationship between dysbiosis and disease activity in light of the putative influence of the genetic background. Shotgun sequencing was performed on fecal DNA isolated from stool samples from 2 groups of adult volunteers: SpA patients (n = 102) and healthy controls (n = 63). A subset of the healthy controls comprised the age-matched siblings of patients whose HLA-B27 status was known. Changes in gut microbiota composition were assessed based on species diversity, enterotypes, and taxonomic and functional differences. Dysbiosis was confirmed in SpA patients as compared to healthy controls. The restriction of microbiota diversity was detected in patients with the most active disease, and the abundance of several bacterial species was correlated with Bath Ankylosing Spondylitis Disease Activity Index score. Among healthy controls, significant differences in microbiota composition were also detected between the HLA-B27-positive and the HLA-B27-negative siblings of SpA patients. We highlighted a decreased abundance of several species of bacteria in SpA patients, especially those bacteria belonging to the Clostridiales order. Among the few species of bacteria showing increased abundance, Ruminococcus gnavus was one of the top differentiating species. These findings reveal that genetic background and level of disease activity are likely to influence the composition of the gut microbiota of patients with SpA. It may be appropriate for further research on chronic arthritis to focus on these key parameters.
Identifiants
pubmed: 35818337
doi: 10.1002/art.42289
pmc: PMC10099252
doi:
Substances chimiques
HLA-B27 Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
41-52Informations de copyright
© 2022 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
Références
ISME J. 2013 Jul;7(7):1256-61
pubmed: 23677008
Front Immunol. 2018 Dec 18;9:2933
pubmed: 30619293
Arthritis Care Res (Hoboken). 2016 Sep;68(9):1320-31
pubmed: 26713432
Nat Microbiol. 2019 Apr;4(4):623-632
pubmed: 30718848
Curr Opin Rheumatol. 2021 Jul 1;33(4):341-347
pubmed: 33973546
Nat Methods. 2015 Jan;12(1):59-60
pubmed: 25402007
Nat Biotechnol. 2014 Aug;32(8):822-8
pubmed: 24997787
Genome Med. 2021 Feb 28;13(1):35
pubmed: 33648559
PLoS One. 2013;8(2):e57923
pubmed: 23460914
Genome Med. 2017 Nov 28;9(1):103
pubmed: 29183332
Arthritis Rheum. 2000 Jun;43(6):1356-65
pubmed: 10857795
Int J Syst Evol Microbiol. 2020 Jan;70(1):23-34
pubmed: 31782700
Arthritis Rheumatol. 2019 Oct;71(10):1642-1650
pubmed: 31038287
Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):12672-12677
pubmed: 31182571
PLoS One. 2012;7(2):e30126
pubmed: 22319561
Forensic Sci Int Genet. 2020 May;46:102257
pubmed: 32058299
Nucleic Acids Res. 2001 Jan 1;29(1):41-3
pubmed: 11125044
Front Microbiol. 2015 Aug 04;6:771
pubmed: 26300854
Immunity. 2014 Jun 19;40(6):843-54
pubmed: 24950204
Proc Natl Acad Sci U S A. 2008 Oct 28;105(43):16731-6
pubmed: 18936492
Nature. 2010 Mar 4;464(7285):59-65
pubmed: 20203603
PLoS One. 2020 Feb 13;15(2):e0228899
pubmed: 32053657
Best Pract Res Clin Rheumatol. 2019 Dec;33(6):101495
pubmed: 32173258
Arthritis Rheumatol. 2015 Mar;67(3):686-691
pubmed: 25417597
Ann Rheum Dis. 2019 Jul;78(7):947-956
pubmed: 30782585
N Engl J Med. 2016 Jun 30;374(26):2563-74
pubmed: 27355535
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Ann Rheum Dis. 2011 Jan;70(1):25-31
pubmed: 21109520
Ann Rheum Dis. 2020 Jan;79(1):132-140
pubmed: 31662318
Arthritis Rheum. 1984 Apr;27(4):361-8
pubmed: 6231933
Arthritis Rheumatol. 2017 Jan;69(1):114-121
pubmed: 27390077
Bioinformatics. 2019 May 1;35(9):1544-1552
pubmed: 30252023
Sci Rep. 2021 Feb 4;11(1):3030
pubmed: 33542369
Nature. 2013 Aug 29;500(7464):541-6
pubmed: 23985870
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Genome Biol. 2012 Apr 16;13(9):R79
pubmed: 23013615
Gut Microbes. 2016 Jul 3;7(4):302-312
pubmed: 27223845
J Autoimmun. 2020 Feb;107:102360
pubmed: 31806420
Genome Biol. 2017 Jul 27;18(1):142
pubmed: 28750650
Microbiome. 2018 Dec 13;6(1):221
pubmed: 30545401
Arthritis Rheum. 2001 Dec;45(6):478-84
pubmed: 11762681
Nat Microbiol. 2016 Jun 13;1(8):16088
pubmed: 27573110
Arthritis Rheumatol. 2015 Jan;67(1):128-39
pubmed: 25319745
Nucleic Acids Res. 2016 Jan 4;44(D1):D286-93
pubmed: 26582926
Ann Rheum Dis. 2017 Sep;76(9):1614-1622
pubmed: 28606969