Quantitative CT Evaluation of Small Pulmonary Vessels Has Functional and Prognostic Value in Pulmonary Hypertension.

Aged Female Humans Computed Tomography Angiography Heart Diseases Hypertension, Pulmonary Lung Prognosis Pulmonary Arterial Hypertension Pulmonary Artery / diagnostic imaging Retrospective Studies

Journal

Radiology
ISSN: 1527-1315
Titre abrégé: Radiology
Pays: United States
ID NLM: 0401260

Informations de publication

Date de publication:
11 2022
Historique:
pubmed: 13 7 2022
medline: 27 10 2022
entrez: 12 7 2022
Statut: ppublish

Résumé

Background The in vivo relationship between peel pulmonary vessels, small pulmonary vessels, and pulmonary hypertension (PH) is not fully understood. Purpose To quantitatively assess peel pulmonary vessel volumes (PPVVs) and small pulmonary vessel volumes (SPVVs) as estimated from CT pulmonary angiography (CTPA) in different subtypes of PH compared with controls, their relationship to pulmonary function and right heart catheter metrics, and their prognostic value. Materials and Methods In this retrospective single-center study performed from January 2008 to February 2018, quantitative CTPA analysis of total SPVV (TSPVV) (0.4- to 2-mm vessel diameter) and PPVV (within 15, 30, and 45 mm from the lung surface) was performed. Results A total of 1823 patients (mean age, 69 years ± 13 [SD]; 1192 women [65%]) were retrospectively analyzed; 1593 patients with PH (mean pulmonary arterial pressure [mPAP], 43 mmHg ± 13 [SD]) were compared with 230 patient controls (mPAP, 19 mm Hg ± 3). The mean vessel volumes in pulmonary peels at 15-, 30-, and 45-mm depths were higher in pulmonary arterial hypertension (PAH) and PH secondary to lung disease compared with chronic thromboembolic PH (45-mm peel, mean difference: 6.4 mL [95% CI: 1, 11] [

Identifiants

DOI: 10.1148/radiol.210482 PMID: 35819325 PMC: PMC9619204
pubmed: 35819325
doi: 10.1148/radiol.210482
pmc: PMC9619204
doi:

Banques de données

ClinicalTrials.gov
['NCT02565030']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

431-440

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 205188/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008894/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/14/6/31350
Pays : United Kingdom

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Auteurs

Yousef Shahin (Y)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0001-7425-7798

Samer Alabed (S)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0002-9960-7587

Dheyaa Alkhanfar (D)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).

Juerg Tschirren (J)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0001-9108-6353

Alex M K Rothman (AMK)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).

Robin Condliffe (R)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).

James M Wild (JM)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0002-7246-8660

David G Kiely (DG)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0003-0184-6502

Andrew J Swift (AJ)

From the Department of Infection, Immunity and Cardiovascular Disease (Y.S., S.A., D.A., A.M.K.R., J.M.W., D.G.K., A.J.S.) and INSIGNEO, Institute for in silico Medicine (D.G.K., A.J.S.), University of Sheffield, Glossop Rd, Sheffield S10 2JF, England; Department of Clinical Radiology, Sheffield Teaching Hospitals, Sheffield, England (Y.S., S.A., A.J.S.); VIDA Diagnostics, Coralville, Iowa (J.T.); and Sheffield Pulmonary Vascular Disease Unit, Royal Hallamshire Hospital, Sheffield, England (R.C., D.G.K.).
ORCID: 0000-0002-8772-409X

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Angiographie par tomodensitométrie › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Appareil respiratoire › Poumon › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Diagnostic › Pronostic › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Hypertension artérielle pulmonaire › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artère pulmonaire › Quantitative CT Evaluation of Small Pulmonary...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Quantitative CT Evaluation of Small Pulmonary...