Comparison of cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil and tiletamine-zolazepam-xylazine in miniature pigs.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2022
2022
Historique:
received:
23
02
2022
accepted:
28
06
2022
entrez:
12
7
2022
pubmed:
13
7
2022
medline:
15
7
2022
Statut:
epublish
Résumé
Effective and adequate anesthesia is conducive to better restrain for pigs during surgical or diagnostic procedures This study aimed to evaluate cardiorespiratory and anesthetic effects of ketamine-midazolam-xylazine-sufentanil or tiletamine-zolazepam-xylazine as general anesthetics in miniature pigs. In phase 1, one of the combinations was administered intramuscularly to miniature pigs. The KMXS protocol combined 10 mg kg-1 ketamine, 0.5 mg kg-1 midazolam, and 2 mg kg-1 xylazine with 2 μg kg-1 sufentanil. The TZX protocol combined 2.2 mg kg-1 tiletamine, 2.2 mg kg-1 zolazepam, and 1.4 mg kg-1 xylazine. After treatment, the mean arterial pressure, systolic arterial pressure, diastolic arterial pressure, heart rate, respiratory rate, peripheral hemoglobin oxygen saturation, rectal temperature, and anesthesia quality were recorded. In phase 2, the feasibility of KMXS and TZX as general anesthetics were evaluated for pig castration. In phase 1, both drug combinations provided smooth induction with similar anesthetic effects. The KMXS protocol provided moderate anesthesia for 60-70 minutes in pigs, while the TZX protocol provided 30-45 minutes. In phase 2, castration was completed smoothly in all pigs with little fluctuation in physiological variables. The KMXS protocol is better for medium-term anesthesia, while the TZX protocol is preferable for short-term anesthesia in pigs.
Identifiants
pubmed: 35819978
doi: 10.1371/journal.pone.0271325
pii: PONE-D-22-05351
pmc: PMC9275679
doi:
Substances chimiques
Anesthetics, General
0
Drug Combinations
0
Xylazine
2KFG9TP5V8
Tiletamine
2YFC543249
Ketamine
690G0D6V8H
Sufentanil
AFE2YW0IIZ
Zolazepam
G1R474U58U
Midazolam
R60L0SM5BC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0271325Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Emerg Med. 2006 May;30(4):407-10
pubmed: 16740450
Can Vet J. 2020 Feb;61(2):173-177
pubmed: 32020937
Vet Anaesth Analg. 2017 Jan;44(1):114-120
pubmed: 27352003
Vet Anaesth Analg. 2018 May;45(3):295-308
pubmed: 29655977
Forensic Sci Int. 2003 Jun 24;134(1):25-8
pubmed: 12842353
Vet Rec. 2010 Sep 25;167(13):489-92
pubmed: 20871083
J S Afr Vet Assoc. 2008 Dec;79(4):205-7
pubmed: 19496321
J Am Vet Med Assoc. 1988 Jun 1;192(11):1612-4
pubmed: 2900824
Vet J. 2015 Sep;205(3):364-8
pubmed: 26070949
Vet Rec. 2010 Aug 14;167(7):245-9
pubmed: 20710032
Vet Anaesth Analg. 2006 Nov;33(6):399-407
pubmed: 17083612
J Am Assoc Lab Anim Sci. 2017 Mar 1;56(2):142-147
pubmed: 28315642
Vet Anaesth Analg. 2020 Sep;47(5):595-603
pubmed: 32792272
Anesthesiology. 2018 May;128(5):912-920
pubmed: 29494402
Animal. 2009 Nov;3(11):1488-96
pubmed: 22444982
Vet Anaesth Analg. 2003 Jan;30(1):24-9
pubmed: 14498914
Vet Rec. 2007 Nov 3;161(18):620-4
pubmed: 17982141
Vet Anaesth Analg. 2006 Sep;33(5):313-27
pubmed: 16916354
Vet Anaesth Analg. 2017 May;44(3):594-599
pubmed: 28533108
Acta Vet Scand. 2020 Mar 12;62(1):14
pubmed: 32164761
Lab Anim. 2015 Apr;49(2):111-6
pubmed: 25378139
Anim Health Res Rev. 2014 Jun;15(1):39-62
pubmed: 25605278
Am J Vet Res. 1979 Dec;40(12):1777-80
pubmed: 525899
Vet Anaesth Analg. 2009 Mar;36(2):151-7
pubmed: 19239653
Shock. 2013 Oct;40(4):247-73
pubmed: 23856921
Vet Anaesth Analg. 2011 Jul;38(4):301-9
pubmed: 21672125
J Neurochem. 1991 Mar;56(3):890-7
pubmed: 1847186
Res Vet Sci. 2019 Aug;125:36-42
pubmed: 31125820
Vet Clin North Am Small Anim Pract. 2011 Sep;41(5):1023-39, viii
pubmed: 21889699
Vet Anaesth Analg. 2007 Mar;34(2):117-24
pubmed: 17316392
Am J Vet Res. 2019 Jan;80(1):33-44
pubmed: 30605029