Noncytotoxic Roles of Granzymes in Health and Disease.

Humans Granzymes / metabolism Wound Healing Serine Proteases Inflammation
barrier dysfunction granzymes inflammation serine proteases wound healing

Journal

Physiology (Bethesda, Md.)
ISSN: 1548-9221
Titre abrégé: Physiology (Bethesda)
Pays: United States
ID NLM: 101208185

Informations de publication

Date de publication:
01 11 2022
Historique:
pubmed: 13 7 2022
medline: 12 10 2022
entrez: 12 7 2022
Statut: ppublish

Résumé

Granzymes are serine proteases previously believed to play exclusive and somewhat redundant roles in lymphocyte-mediated target cell death. However, recent studies have challenged this paradigm. Distinct substrate profiles and functions have since emerged for each granzyme while their dysregulated proteolytic activities have been linked to diverse pathologies.

Identifiants

DOI: 10.1152/physiol.00011.2022 PMID: 35820180
pubmed: 35820180
doi: 10.1152/physiol.00011.2022
doi:

Substances chimiques

Granzymes EC 3.4.21.-
Serine Proteases EC 3.4.-

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

323-348

Subventions

Organisme : CIHR
Pays : Canada

Auteurs

Katlyn C Richardson (KC)

International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Karen Jung (K)

International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

Julian Pardo (J)

Fundación Instituto de Investigación Sanitaria Aragón (IIS Aragón), Biomedical Research Centre of Aragon (CIBA), Zaragoza, Spain.
Department of Microbiology, Radiology, Pediatrics and Public Health, University of Zaragoza, Zaragoza, Spain.
CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Zaragoza, Spain.

Christopher T Turner (CT)

Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Melbourne, Victoria, Australia.
Future Industries Institute, University of South Australia, Adelaide, South Australia, Australia.
ORCID: 0000-0001-7409-4386

David J Granville (DJ)

International Collaboration on Repair Discoveries (ICORD), British Columbia Professional Firefighters' Wound Healing Laboratory, Vancouver Coastal Health Research Institute, Vancouver, British Columbia, Canada.
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
ORCID: 0000-0001-6985-2816

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Noncytotoxic Roles of Granzymes in Health and Disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Granzymes › Noncytotoxic Roles of Granzymes in Health and Disease.
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cicatrisation de plaie › Noncytotoxic Roles of Granzymes in Health and Disease.
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Noncytotoxic Roles of Granzymes in Health and Disease.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Noncytotoxic Roles of Granzymes in Health and Disease.