Alternative splicing as a source of phenotypic diversity.
Journal
Nature reviews. Genetics
ISSN: 1471-0064
Titre abrégé: Nat Rev Genet
Pays: England
ID NLM: 100962779
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
accepted:
13
06
2022
pubmed:
13
7
2022
medline:
20
10
2022
entrez:
12
7
2022
Statut:
ppublish
Résumé
A major goal of evolutionary genetics is to understand the genetic processes that give rise to phenotypic diversity in multicellular organisms. Alternative splicing generates multiple transcripts from a single gene, enriching the diversity of proteins and phenotypic traits. It is well established that alternative splicing contributes to key innovations over long evolutionary timescales, such as brain development in bilaterians. However, recent developments in long-read sequencing and the generation of high-quality genome assemblies for diverse organisms has facilitated comparisons of splicing profiles between closely related species, providing insights into how alternative splicing evolves over shorter timescales. Although most splicing variants are probably non-functional, alternative splicing is nonetheless emerging as a dynamic, evolutionarily labile process that can facilitate adaptation and contribute to species divergence.
Identifiants
pubmed: 35821097
doi: 10.1038/s41576-022-00514-4
pii: 10.1038/s41576-022-00514-4
doi:
Substances chimiques
Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
697-710Subventions
Organisme : Wellcome Trust
ID : 206194
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 218328
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/R007500/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 209368/Z/17/Z
Pays : United Kingdom
Informations de copyright
© 2022. Springer Nature Limited.
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