Type 1 Innate Lymphoid Cells Are Proinflammatory Effector Cells in Ischemia-Reperfusion Injury of Steatotic Livers.
T-bet
Type 1 innate lymphoid cells
fatty liver disease
innate lymphoid cells
ischemia-reperfusion injury
liver transplantation
natural killer cells
phasor fluorescence lifetime imaging
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
24
03
2022
accepted:
24
05
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
16
7
2022
Statut:
epublish
Résumé
Innate lymphoid cells (ILCs), the most recently described family of lymphoid cells, play fundamental roles in tissue homeostasis through the production of key cytokine. Group 1 ILCs, comprised of conventional natural killer cells (cNKs) and type 1 ILCs (ILC1s), have been implicated in regulating immune-mediated inflammatory diseases. However, the role of ILC1s in nonalcoholic fatty liver disease (NAFLD) and ischemia-reperfusion injury (IRI) is unclear. Here, we investigated the role of ILC1 and cNK cells in a high-fat diet (HFD) murine model of partial warm IRI. We demonstrated that hepatic steatosis results in more severe IRI compared to non-steatotic livers. We further elicited that HFD-IRI mice show a significant increase in the ILC1 population, whereas the cNK population was unchanged. Since ILC1 and cNK are major sources of IFN-γ and TNF-α, we measured the level of
Identifiants
pubmed: 35833123
doi: 10.3389/fimmu.2022.899525
pmc: PMC9272906
doi:
Substances chimiques
Cytokines
0
Homeodomain Proteins
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
899525Informations de copyright
Copyright © 2022 Kang, Liggett, Patil, Ranjit, Loh, Duttargi, Cui, Oza, Frank, Kwon, Kallakury, Robson, Fishbein, Cui, Khan and Kroemer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Am J Transplant. 2021 Feb;21(2):787-797
pubmed: 32594614
Innate Immun. 2015 Aug;21(6):665-73
pubmed: 25977358
Int J Mol Sci. 2018 Jun 19;19(6):
pubmed: 29921749
Front Immunol. 2019 Sep 11;10:2180
pubmed: 31572388
Biophys J. 2014 Dec 16;107(12):2775-2785
pubmed: 25517145
Annu Rev Biophys. 2021 May 6;50:575-593
pubmed: 33957055
J Biomed Opt. 2012 Nov;17(11):116023
pubmed: 23214184
Nat Med. 2015 Jul;21(7):698-708
pubmed: 26121198
Am J Physiol Gastrointest Liver Physiol. 2013 Dec;305(12):G891-9
pubmed: 24136786
Immunol Rev. 2018 Nov;286(1):6-22
pubmed: 30294966
Microsc Res Tech. 2014 May;77(5):368-73
pubmed: 24610799
Cell Death Dis. 2018 Jan 26;9(2):132
pubmed: 29374146
Gut. 2022 Jun;71(6):1161-1175
pubmed: 34340996
J Immunol Res. 2020 Feb 25;2020:6056373
pubmed: 32185239
Nat Rev Nephrol. 2021 Feb;17(2):128-144
pubmed: 32948857
Immunity. 2020 Jan 14;52(1):96-108.e9
pubmed: 31810881
Biophys J. 2008 Jan 15;94(2):L14-6
pubmed: 17981902
Front Immunol. 2020 Jun 17;11:1060
pubmed: 32625201
Pathogens. 2020 Oct 24;9(11):
pubmed: 33114395
Am J Transplant. 2021 Feb;21(2):614-625
pubmed: 32713098
Surg Clin North Am. 2010 Aug;90(4):665-77
pubmed: 20637940
Arch Toxicol. 2020 Feb;94(2):439-448
pubmed: 32060585
Nat Rev Immunol. 2011 Oct 14;11(11):723-37
pubmed: 21997792
Nucleic Acids Res. 2015 Jul 1;43(W1):W566-70
pubmed: 25969447
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4560-5
pubmed: 15070757
J Autoimmun. 2016 Feb;67:29-35
pubmed: 26422992
J Immunol. 2008 Dec 1;181(11):7489-98
pubmed: 19017938
Nat Protoc. 2018 Sep;13(9):1979-2004
pubmed: 30190551
Curr Opin Immunol. 2016 Feb;38:86-93
pubmed: 26736074
Biomed Opt Express. 2017 Jun 01;8(7):3143-3154
pubmed: 28717559
Immunity. 2004 Apr;20(4):477-94
pubmed: 15084276
Front Immunol. 2019 May 28;10:1192
pubmed: 31191550
Front Immunol. 2021 Feb 18;12:640869
pubmed: 33679803
J Am Soc Nephrol. 2011 Apr;22(4):732-42
pubmed: 21436290
Sci Rep. 2015 May 20;5:9848
pubmed: 25993434
Front Immunol. 2021 Oct 06;12:754106
pubmed: 34691073
Clin Transl Immunology. 2021 Jun 05;10(6):e1287
pubmed: 34136217
Hepatology. 2010 May;51(5):1702-11
pubmed: 20146261
Nat Immunol. 2016 Jun 21;17(7):758-64
pubmed: 27328005
Immunity. 2013 Apr 18;38(4):769-81
pubmed: 23453631
Blood. 2009 May 28;113(22):5488-96
pubmed: 19234143
Proc Natl Acad Sci U S A. 2019 Jul 2;116(27):13533-13542
pubmed: 31196960
Front Immunol. 2021 Oct 05;12:761920
pubmed: 34675939
Nature. 2015 Jan 15;517(7534):293-301
pubmed: 25592534