Does slow release oral morphine have impact on craving and impulsivity in heroin dependent individuals?
Journal
International clinical psychopharmacology
ISSN: 1473-5857
Titre abrégé: Int Clin Psychopharmacol
Pays: England
ID NLM: 8609061
Informations de publication
Date de publication:
01 01 2023
01 01 2023
Historique:
pubmed:
15
7
2022
medline:
15
12
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
Craving and impulsivity are addiction components which explain why heroin-dependant individuals (HDI), continue using heroin despite not wanting to do so. Opioid maintenance treatment (OMT), such as slow-release oral morphine (SROM), is the most effective treatment for opioid dependence. However, the impact of SROM on craving and impulsivity remains unclear. In this observational study, 23 HDI receiving SROM, their usual OMT, took part in the experiment. Each of the participants filled in the perceived level of craving with a visual analog scale. Their impulsivity was assessed via three laboratory tasks, the stop-signal reaction time, the Balloon Analogue Risk Task and delay discounting. Each evaluation was performed before and after SROM administration. Craving was significantly reduced after administration of SROM (difference 2.83; P = 0.0010), whereas there were no significant differences in performance in the three laboratory tasks. In the long term, we observed an improvement on delay discounting correlated with the duration and dosage of SROM. The acute impact of SROM appears to significantly reduce craving, without impacting impulsivity. Observation of the correlation between delay discounting and the duration and dosage of OMT is of great interest and should be studied further.
Identifiants
pubmed: 35833289
doi: 10.1097/YIC.0000000000000418
pii: 00004850-202301000-00004
pmc: PMC9722371
doi:
Substances chimiques
Heroin
70D95007SX
Morphine
76I7G6D29C
Types de publication
Observational Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-22Informations de copyright
Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc.
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