Is there an unmet medical need for improved hearing restoration?
clinical translation
cochlear implant
gene therapy
hearing impairment
optogenetic hearing restoration
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
08 08 2022
08 08 2022
Historique:
revised:
12
05
2022
received:
28
01
2022
accepted:
02
06
2022
pubmed:
15
7
2022
medline:
10
8
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
Hearing impairment, the most prevalent sensory deficit, affects more than 466 million people worldwide (WHO). We presently lack causative treatment for the most common form, sensorineural hearing impairment; hearing aids and cochlear implants (CI) remain the only means of hearing restoration. We engaged with CI users to learn about their expectations and their willingness to collaborate with health care professionals on establishing novel therapies. We summarize upcoming CI innovations, gene therapies, and regenerative approaches and evaluate the chances for clinical translation of these novel strategies. We conclude that there remains an unmet medical need for improving hearing restoration and that we are likely to witness the clinical translation of gene therapy and major CI innovations within this decade.
Identifiants
pubmed: 35833443
doi: 10.15252/emmm.202215798
pmc: PMC9358394
doi:
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e15798Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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