A quantitative biophysical principle to explain the 3D cellular connectivity in curved epithelia.
bioimage analysis
computational geometry
developmental systems biology
mathematical/biophysical modeling
tissue/cellular biophysics
Journal
Cell systems
ISSN: 2405-4720
Titre abrégé: Cell Syst
Pays: United States
ID NLM: 101656080
Informations de publication
Date de publication:
17 08 2022
17 08 2022
Historique:
received:
13
04
2021
revised:
15
02
2022
accepted:
15
06
2022
pubmed:
15
7
2022
medline:
23
8
2022
entrez:
14
7
2022
Statut:
ppublish
Résumé
Epithelial cell organization and the mechanical stability of tissues are closely related. In this context, it has been recently shown that packing optimization in bended or folded epithelia is achieved by an energy minimization mechanism that leads to a complex cellular shape: the "scutoid". Here, we focus on the relationship between this shape and the connectivity between cells. We use a combination of computational, experimental, and biophysical approaches to examine how energy drivers affect the three-dimensional (3D) packing of tubular epithelia. We propose an energy-based stochastic model that explains the 3D cellular connectivity. Then, we challenge it by experimentally reducing the cell adhesion. As a result, we observed an increment in the appearance of scutoids that correlated with a decrease in the energy barrier necessary to connect with new cells. We conclude that tubular epithelia satisfy a quantitative biophysical principle that links tissue geometry and energetics with the average cellular connectivity.
Identifiants
pubmed: 35835108
pii: S2405-4712(22)00273-3
doi: 10.1016/j.cels.2022.06.003
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
631-643.e8Informations de copyright
Copyright © 2022. Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.