SIRT3-mediated deacetylation protects inner hair cell synapses in a H

Hair Cells, Auditory, Inner / metabolism Hydrogen Peroxide / metabolism Oxidative Stress Reactive Oxygen Species / metabolism Sirtuin 3 / genetics Superoxide Dismutase / genetics Synapses / metabolism
Deacetylation FOXO3a Ribbon synapses SOD2 Sirtuin 3

Journal

Experimental cell research
ISSN: 1090-2422
Titre abrégé: Exp Cell Res
Pays: United States
ID NLM: 0373226

Informations de publication

Date de publication:
15 09 2022
Historique:
received: 27 04 2022
revised: 06 07 2022
accepted: 07 07 2022
pubmed: 15 7 2022
medline: 12 8 2022
entrez: 14 7 2022
Statut: ppublish

Résumé

Oxidative stress is considered a driving event in the damage to inner hair cell (IHC) synapses. Mitochondrial deacetylase sirtuin 3 (SIRT3) is an important regulator of reactive oxygen species (ROS) production. However, the effect of SIRT3 on IHC synapses remains elusive. In this study, we treated cochlear basilar membrane (CBM) with hydrogen peroxide (H

Identifiants

DOI: 10.1016/j.yexcr.2022.113280 PMID: 35835175
pubmed: 35835175
pii: S0014-4827(22)00273-7
doi: 10.1016/j.yexcr.2022.113280
pii:
doi:

Substances chimiques

Reactive Oxygen Species 0
Hydrogen Peroxide BBX060AN9V
Superoxide Dismutase EC 1.15.1.1
Sirtuin 3 EC 3.5.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

113280

Informations de copyright

Copyright © 2022 Elsevier Inc. All rights reserved.

Auteurs

Chunli Zhao (C)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China.

Wenqi Liang (W)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China.

Zijing Yang (Z)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China.

Zhongrui Chen (Z)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China.

Zhengde Du (Z)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China. Electronic address: duzhengde@ccmu.edu.cn.

Shusheng Gong (S)

Department of Otolaryngology Head and Neck Surgery, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China; Clinical Center for Hearing Loss, Capital Medical University, Beijing, 100050, China. Electronic address: gongss@ccmu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Cellules neuroépithéliales › Cellules ciliées auditives › Cellules ciliées auditives internes › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Peroxydes › Peroxyde d'hydrogène › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines mitochondriales › Sirtuine-3 › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › SIRT3-mediated deacetylation protects inner...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Jonctions intercellulaires › Synapses › SIRT3-mediated deacetylation protects inner...