The association of age at menarche and adult height with mammographic density in the International Consortium of Mammographic Density.
Breast cancer
Height
Mammographic density
Menarche
Journal
Breast cancer research : BCR
ISSN: 1465-542X
Titre abrégé: Breast Cancer Res
Pays: England
ID NLM: 100927353
Informations de publication
Date de publication:
14 07 2022
14 07 2022
Historique:
received:
07
02
2022
accepted:
29
06
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk. Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche. In pooled analyses, later age at menarche was associated with higher per cent density (β In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.
Sections du résumé
BACKGROUND
Early age at menarche and tall stature are associated with increased breast cancer risk. We examined whether these associations were also positively associated with mammographic density, a strong marker of breast cancer risk.
METHODS
Participants were 10,681 breast-cancer-free women from 22 countries in the International Consortium of Mammographic Density, each with centrally assessed mammographic density and a common set of epidemiologic data. Study periods for the 27 studies ranged from 1987 to 2014. Multi-level linear regression models estimated changes in square-root per cent density (√PD) and dense area (√DA) associated with age at menarche and adult height in pooled analyses and population-specific meta-analyses. Models were adjusted for age at mammogram, body mass index, menopausal status, hormone therapy use, mammography view and type, mammographic density assessor, parity and height/age at menarche.
RESULTS
In pooled analyses, later age at menarche was associated with higher per cent density (β
CONCLUSIONS
In one of the largest international studies to date, later age at menarche was positively associated with mammographic density. This is in contrast to its association with breast cancer risk, providing little evidence of mediation. Increased height was also positively associated with mammographic density, particularly dense area. These results suggest a complex relationship between growth and development, mammographic density and breast cancer risk. Future studies should evaluate the potential mediation of the breast cancer effects of taller stature through absolute breast density.
Identifiants
pubmed: 35836268
doi: 10.1186/s13058-022-01545-9
pii: 10.1186/s13058-022-01545-9
pmc: PMC9284807
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
49Subventions
Organisme : NCI NIH HHS
ID : R03 CA167771
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177150
Pays : United States
Organisme : NCI NIH HHS
ID : N01 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA097396
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA054281
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA116201
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA186107
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015083
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA085265
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA131332
Pays : United States
Organisme : NCI NIH HHS
ID : UM1 CA176726
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA124865
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA140286
Pays : United States
Informations de copyright
© 2022. The Author(s).
Références
Breast Cancer Res. 2016 Sep 21;18(1):94
pubmed: 27654859
Am J Epidemiol. 2011 Oct 15;174(8):909-18
pubmed: 21911827
Breast Dis. 1998 Aug;10(3-4):113-26
pubmed: 15687568
Int J Cancer. 2006 Nov 1;119(9):2231-5
pubmed: 16823843
Cancer Epidemiol Biomarkers Prev. 2004 Nov;13(11 Pt 1):1751-8
pubmed: 15533903
Am J Phys Anthropol. 2005 Sep;128(1):220-9
pubmed: 15761809
Best Pract Res Clin Endocrinol Metab. 2002 Jun;16(2):225-41
pubmed: 12064890
Breast Cancer Res. 2006;8(4):R43
pubmed: 16859501
Int J Environ Res Public Health. 2017 Oct 24;14(10):
pubmed: 29064384
Cancer Epidemiol Biomarkers Prev. 2006 Mar;15(3):449-55
pubmed: 16537700
Bonekey Rep. 2013 Oct 02;2:437
pubmed: 24422135
Cancer Epidemiol Biomarkers Prev. 2006 Jun;15(6):1159-69
pubmed: 16775176
J Natl Cancer Inst. 2015 Aug 20;107(11):
pubmed: 26296642
Breast Cancer Res. 2017 Feb 7;19(1):13
pubmed: 28173872
Cancer Epidemiol. 2016 Feb;40:141-51
pubmed: 26724463
Cancer Epidemiol Biomarkers Prev. 2006 Nov;15(11):2086-92
pubmed: 17119032
Br J Cancer. 2002 Oct 7;87(8):876-82
pubmed: 12373602
Semin Cell Dev Biol. 2021 Jun;114:143-158
pubmed: 33309487
Cancer Epidemiol Biomarkers Prev. 2005 May;14(5):1065-73
pubmed: 15894654
JAMA Oncol. 2015 Aug;1(5):611-21
pubmed: 26182172
Lancet Oncol. 2012 Nov;13(11):1141-51
pubmed: 23084519
J Adolesc Health. 2021 Mar;68(3):517-522
pubmed: 32888770
Br J Cancer. 1998 Nov;78(9):1233-8
pubmed: 9820186
Hum Genet. 2006 Nov;120(4):571-80
pubmed: 16933140
Nat Rev Cancer. 2004 Jul;4(7):505-18
pubmed: 15229476
Cancer Epidemiol Biomarkers Prev. 2007 Oct;16(10):2144-9
pubmed: 17932363
Hum Mol Genet. 2015 Mar 15;24(6):1791-800
pubmed: 25429064
Lancet Oncol. 2010 Jun;11(6):530-42
pubmed: 20472501
Cancer Causes Control. 2004 Nov;15(9):947-55
pubmed: 15577297
PLoS One. 2015 Jul 21;10(7):e0133761
pubmed: 26196859
Am J Epidemiol. 2005 Oct 1;162(7):623-32
pubmed: 16107566
J Public Health (Oxf). 2016 Sep;38(3):607-613
pubmed: 26036702
Cancer Epidemiol Biomarkers Prev. 2019 Jan;28(1):22-31
pubmed: 30206060
Breast Cancer Res. 2014 Jan 20;16(1):R4
pubmed: 24443815
Breast Cancer Res. 2016 Dec 19;18(1):130
pubmed: 27993168
PLoS Med. 2017 Jun 30;14(6):e1002335
pubmed: 28666001
Breast Cancer Res Treat. 2014 Apr;144(3):479-502
pubmed: 24615497
Phys Med Biol. 1994 Oct;39(10):1629-38
pubmed: 15551535