Imaging Glioblastoma Metabolism by Using Hyperpolarized [1-

Bicarbonates Glioblastoma / diagnostic imaging Humans Lactate Dehydrogenase 5 Lactic Acid Male Middle Aged Prospective Studies Pyruvic Acid / metabolism

Cancer Glioblastoma Hyperpolarized 13C MRI MRI Metabolism Neuro-oncology

Journal

Radiology. Imaging cancer

ISSN: 2638-616X

Titre abrégé: Radiol Imaging Cancer

Pays: United States

ID NLM: 101765309

Informations de publication

Date de publication:
07 2022

Historique:

entrez: 15 7 2022

pubmed: 16 7 2022

medline: 20 7 2022

Statut: ppublish

Résumé

Purpose To evaluate glioblastoma (GBM) metabolism by using hyperpolarized carbon 13 (

Identifiants

DOI: 10.1148/rycan.210076 PMID: 35838532 PMC: PMC9360994

pubmed: 35838532

doi: 10.1148/rycan.210076

pmc: PMC9360994

doi:

Substances chimiques

Bicarbonates 0

Lactic Acid 33X04XA5AT

Pyruvic Acid 8558G7RUTR

Lactate Dehydrogenase 5 EC 1.1.1.27.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e210076

Subventions

Organisme : Wellcome Trust

Pays : United Kingdom

Organisme : Cancer Research UK

ID : C19212/A16628

Pays : United Kingdom

Organisme : Cancer Research UK

ID : C19212/A911376

Pays : United Kingdom

Organisme : Cancer Research UK

ID : C8742/A18097

Pays : United Kingdom

Organisme : Cancer Research UK

ID : C197/A16465

Pays : United Kingdom

Organisme : Cancer Research UK

ID : A25040

Pays : United Kingdom

Organisme : Cancer Research UK

ID : A29580

Pays : United Kingdom

Organisme : Cancer Research UK

ID : C9685/A25177

Pays : United Kingdom

Organisme : Department of Health

ID : BRC-1215-20014

Pays : United Kingdom

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Auteurs

Fulvio Zaccagna (F)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0001-6838-9532

Mary A McLean (MA)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-3752-0179

James T Grist (JT)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0001-7223-4031

Joshua Kaggie (J)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0001-6706-3442

Richard Mair (R)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Frank Riemer (F)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Ramona Woitek (R)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-9146-9159

Andrew B Gill (AB)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Surrin Deen (S)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-6206-7337

Charlie J Daniels (CJ)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Stephan Ursprung (S)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-2476-178X

Rolf F Schulte (RF)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-1334-1264

Kieren Allinson (K)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Anita Chhabra (A)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-9899-8010

Marie-Christine Laurent (MC)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Matthew Locke (M)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-3481-2691

Amy Frary (A)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Sarah Hilborne (S)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-0790-020X

Ilse Patterson (I)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Bruno D Carmo (BD)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-2944-0766

Rhys Slough (R)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Ian Wilkinson (I)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Bristi Basu (B)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

James Wason (J)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Jonathan H Gillard (JH)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Tomasz Matys (T)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-2285-5715

Colin Watts (C)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Stephen J Price (SJ)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0002-7535-3009

Thomas Santarius (T)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Martin J Graves (MJ)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Sarah Jefferies (S)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

Kevin M Brindle (KM)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-3883-6287

Ferdia A Gallagher (FA)

From the Departments of Radiology (F.Z., J.T.G., J.K., F.R., R.W., A.B.G., S.D., C.J.D., S.U., M.C.L., M.L., A.F., S.H., J.H.G., T.M., M.J.G., F.A.G.), Clinical Neurosciences (R.M., C.W., S.J.P., T.S.), and Medicine (I.W.), University of Cambridge School of Clinical Medicine, Cambridge, England; Cancer Research UK Cambridge Institute (M.A.M., S.U., K.M.B.), Medical Research Council Biostatistics Unit (J.W.), and Department of Biochemistry (K.M.B.), University of Cambridge, Li Ka Shing Centre, Robinson Way, Cambridge, CB2 0RE, England; Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria (R.W.); GE Healthcare, Munich, Germany (R.F.S.); Department of Pathology (K.A.), Cambridge Cancer Trials Centre (A.C.), Department of Radiology (I.P., B.D.C., R.S.), and Department of Oncology (B.B., S.J.), Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, England; and Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, England (J.W.).

ORCID: 0000-0003-4784-5230

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Classifications MeSH

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