Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study.
adaptive servo ventilation
central sleep apnea
periodic leg movements during sleep
polysomnography
systolic heart failure
Journal
Journal of sleep research
ISSN: 1365-2869
Titre abrégé: J Sleep Res
Pays: England
ID NLM: 9214441
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
23
06
2022
received:
23
02
2022
accepted:
23
06
2022
pubmed:
16
7
2022
medline:
11
11
2022
entrez:
15
7
2022
Statut:
ppublish
Résumé
This SERVE-HF (Treatment of Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure) sub study analysis evaluated polysomnography (PSG) data in patients with heart failure with reduced ejection fraction (HFrEF) and predominant central sleep apnea (CSA) randomised to guideline-based medical therapy, with or without adaptive servo ventilation (ASV). Patients underwent full overnight PSG at baseline and at 12 months. All PSG recordings were analysed by a core laboratory. Only data for patients with baseline and 3- or 12-month values were included. The sub study included 312 patients; the number with available PSG data differed for each variable (94-103 in the control group, 77-99 in the ASV group). After 12 months, baseline-adjusted respiratory measures were significantly better in the ASV group versus control. Although some between-group differences in sleep measures were seen at 12 months (e.g., better sleep efficiency in the ASV group), these were unlikely to be clinically significant. The number of periodic leg movements during sleep (PLMS) increased in the ASV group (p = 0.039). At 12 months, the respiratory arousal index was significantly lower in the ASV versus control group (p < 0.001), whilst the PLMS-related arousal index was significantly higher in the ASV group (p = 0.04 versus control). ASV attenuated the respiratory variables characterising sleep apnea in patients with HFrEF and predominant CSA in SERVE-HF. Sleep quality improvements during ASV therapy were small and unlikely to be clinically significant. The increase in PLMS and PLMS-related arousals during ASV warrants further investigation, particularly relating to their potential association with increased cardiovascular risk.
Identifiants
pubmed: 35840352
doi: 10.1111/jsr.13694
pmc: PMC9787165
doi:
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13694Informations de copyright
© 2022 The Authors. Journal of Sleep Research published by John Wiley & Sons Ltd on behalf of European Sleep Research Society.
Références
Am J Respir Crit Care Med. 2001 Aug 15;164(4):614-9
pubmed: 11520725
Am J Cardiol. 2019 Feb 15;123(4):632-637
pubmed: 30554649
Eur Heart J. 2016 Jul 14;37(27):2129-2200
pubmed: 27206819
Int Heart J. 2011;52(4):218-23
pubmed: 21828947
Chest. 1996 Jun;109(6):1497-502
pubmed: 8769500
Sleep Med. 2016 Jan;17:25-31
pubmed: 26847970
Circ J. 2017 Mar 24;81(4):495-500
pubmed: 28100870
Eur J Prev Cardiol. 2019 Oct 11;28(2):189–200
pubmed: 33611525
Sleep Med. 2008 Aug;9(6):652-9
pubmed: 18024166
Sleep. 2009 Jan;32(1):91-8
pubmed: 19189783
Sleep Breath. 2009 Mar;13(1):43-7
pubmed: 18592284
Sleep. 2003 Sep;26(6):717-20
pubmed: 14572125
Eur Heart J. 2011 Jan;32(1):61-74
pubmed: 20846992
N Engl J Med. 2005 Nov 10;353(19):2025-33
pubmed: 16282177
J Clin Sleep Med. 2012 Oct 15;8(5):597-619
pubmed: 23066376
Eur Respir J. 2013 Nov;42(5):1244-54
pubmed: 23222879
Sleep Med. 2013 Jun;14(6):502-9
pubmed: 23628241
N Engl J Med. 2015 Sep 17;373(12):1095-105
pubmed: 26323938
Am J Respir Crit Care Med. 1995 Aug;152(2):473-9
pubmed: 7633695
Am J Respir Crit Care Med. 2003 Nov 1;168(9):1109-14
pubmed: 12928310
Sleep Breath. 2010 Dec;14(4):359-63
pubmed: 20099083
Eur J Heart Fail. 2008 Jun;10(6):581-6
pubmed: 18486550
J Clin Neurophysiol. 2012 Aug;29(4):339-44
pubmed: 22854768
Heart. 2009 May;95(10):819-24
pubmed: 19131443
Clin Res Cardiol. 2016 Mar;105(3):189-95
pubmed: 26342603
Sleep Breath. 2017 Dec;21(4):919-927
pubmed: 28389910
Heart. 2006 Mar;92(3):337-42
pubmed: 15964943
Eur Respir J. 2017 Jan 18;49(1):
pubmed: 27920092
Eur J Heart Fail. 2007 Mar;9(3):251-7
pubmed: 17027333
Am J Cardiol. 2011 Feb 1;107(3):447-51
pubmed: 21257013
Sleep. 2013 Mar 01;36(3):363-8
pubmed: 23450252
Eur J Heart Fail. 2013 Aug;15(8):937-43
pubmed: 23535165
Respir Physiol Neurobiol. 2020 Jan;271:103286
pubmed: 31526873
Eur J Heart Fail. 2018 Mar;20(3):536-544
pubmed: 29193576
J Sleep Res. 2022 Dec;31(6):e13694
pubmed: 35840352