Childhood body mass index and associations with infant gut metabolites and secretory IgA: findings from a prospective cohort study.


Journal

International journal of obesity (2005)
ISSN: 1476-5497
Titre abrégé: Int J Obes (Lond)
Pays: England
ID NLM: 101256108

Informations de publication

Date de publication:
09 2022
Historique:
received: 16 02 2022
accepted: 30 06 2022
revised: 28 06 2022
pubmed: 16 7 2022
medline: 25 8 2022
entrez: 15 7 2022
Statut: ppublish

Résumé

Differences in gut microbiota, metabolites and immune markers have been observed between individuals with and without obesity. Our study determined the temporal association between infant fecal gut metabolites, sIgA and body mass index (BMI) z score of preschool children, independent of pre/postnatal factors. The study includes a subset of 647 infants from the CHILD Cohort Study (recruited between January 1, 2009, and December 31, 2012). Fecal metabolites and sIgA were measured at 3-4 months of age, and age and sex adjusted BMI z scores at 1 and 3 years of age. Associations between the metabolites, IgA, and child BMI z scores at age 1 and 3 years were tested using linear regression adjusted for pre/postnatal factors (breastfeeding, birthweight-for-gestational age, birthmode and IAP, solid food introduction). Mean BMI z score for all infants was 0.34 (SD 1.16) at 1 year (N = 647) and 0.71 (SD 1.06) at 3 years (N = 573). High fecal formate in infancy was associated with a significantly lower BMI z score (adjusted mean difference -0.23 (95% CI -0.42, -0.04)) and high butyrate was associated with a higher BMI z score (adjusted mean difference 0.21 (95% CI 0.01, 0.41)) at age 3 years only. The influence of formate and butyrate on BMI z score at age 3 were seen only in those that were not exclusively breastfed at stool sample collection (adjusted mean difference for high formate/EBF- group: -0.33 (95%CI -0.55, -0.10) and 0.25 (95% CI 0.02, 0.47) for high butyrate/EBF- group). No associations were seen between sIgA and BMI z score at age 1 or 3 years in adjusted regression models. Differences in fecal metabolite levels in early infancy were associated with childhood BMI. This study identifies an important area of future research in understanding the pathogenesis of obesity.

Sections du résumé

BACKGROUND/OBJECTIVES
Differences in gut microbiota, metabolites and immune markers have been observed between individuals with and without obesity. Our study determined the temporal association between infant fecal gut metabolites, sIgA and body mass index (BMI) z score of preschool children, independent of pre/postnatal factors.
SUBJECTS/METHODS
The study includes a subset of 647 infants from the CHILD Cohort Study (recruited between January 1, 2009, and December 31, 2012). Fecal metabolites and sIgA were measured at 3-4 months of age, and age and sex adjusted BMI z scores at 1 and 3 years of age. Associations between the metabolites, IgA, and child BMI z scores at age 1 and 3 years were tested using linear regression adjusted for pre/postnatal factors (breastfeeding, birthweight-for-gestational age, birthmode and IAP, solid food introduction).
RESULTS
Mean BMI z score for all infants was 0.34 (SD 1.16) at 1 year (N = 647) and 0.71 (SD 1.06) at 3 years (N = 573). High fecal formate in infancy was associated with a significantly lower BMI z score (adjusted mean difference -0.23 (95% CI -0.42, -0.04)) and high butyrate was associated with a higher BMI z score (adjusted mean difference 0.21 (95% CI 0.01, 0.41)) at age 3 years only. The influence of formate and butyrate on BMI z score at age 3 were seen only in those that were not exclusively breastfed at stool sample collection (adjusted mean difference for high formate/EBF- group: -0.33 (95%CI -0.55, -0.10) and 0.25 (95% CI 0.02, 0.47) for high butyrate/EBF- group). No associations were seen between sIgA and BMI z score at age 1 or 3 years in adjusted regression models.
CONCLUSION AND RELEVANCE
Differences in fecal metabolite levels in early infancy were associated with childhood BMI. This study identifies an important area of future research in understanding the pathogenesis of obesity.

Identifiants

pubmed: 35840772
doi: 10.1038/s41366-022-01183-3
pii: 10.1038/s41366-022-01183-3
doi:

Substances chimiques

Butyrates 0
Formates 0
Immunoglobulin A, Secretory 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1712-1719

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Sarah L Bridgman (SL)

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Nilusha Malmuthuge (N)

Agriculture Agri-Food Canada, Lethbridge Research and Development Centre, Lethbridge, AB, Canada.

Rupasri Mandal (R)

Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

Catherine J Field (CJ)

Department of Agriculture, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada.

Andrea M Haqq (AM)

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Department of Agriculture, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada.

Piushkumar J Mandhane (PJ)

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.

Theo J Moraes (TJ)

Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

Stuart E Turvey (SE)

Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
BC Children's Hospital, Vancouver, BC, Canada.

Elinor Simons (E)

Developmental Origins of Chronic Diseases in Children Network (DEVOTION), Department of Pediatrics and Child Health, Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.

Padmaja Subbarao (P)

Department of Pediatrics and Physiology, Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.

James A Scott (JA)

Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.

David S Wishart (DS)

Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

Anita L Kozyrskyj (AL)

Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. kozyrsky@ualberta.ca.

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