Proton export upregulates aerobic glycolysis.
CA-IX
Cancer
Glycolysis
Metastasis
PMA1
Proton
Warburg
pH
Journal
BMC biology
ISSN: 1741-7007
Titre abrégé: BMC Biol
Pays: England
ID NLM: 101190720
Informations de publication
Date de publication:
15 07 2022
15 07 2022
Historique:
received:
09
04
2022
accepted:
30
05
2022
entrez:
15
7
2022
pubmed:
16
7
2022
medline:
20
7
2022
Statut:
epublish
Résumé
Aggressive cancers commonly ferment glucose to lactic acid at high rates, even in the presence of oxygen. This is known as aerobic glycolysis, or the "Warburg Effect." It is widely assumed that this is a consequence of the upregulation of glycolytic enzymes. Oncogenic drivers can increase the expression of most proteins in the glycolytic pathway, including the terminal step of exporting H To test this hypothesis, we stably transfected lowly glycolytic MCF-7, U2-OS, and glycolytic HEK293 cells to express proton-exporting systems: either PMA1 (plasma membrane ATPase 1, a yeast H Therefore, cancer cells which increase export of H
Identifiants
pubmed: 35840963
doi: 10.1186/s12915-022-01340-0
pii: 10.1186/s12915-022-01340-0
pmc: PMC9287933
doi:
Substances chimiques
Protons
0
Lactic Acid
33X04XA5AT
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
163Subventions
Organisme : NCI NIH HHS
ID : R01 CA077575
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA076292
Pays : United States
Organisme : NCI NIH HHS
ID : K00 CA234942
Pays : United States
Organisme : NCI NIH HHS
ID : F99 CA234942
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA193489
Pays : United States
Informations de copyright
© 2022. The Author(s).
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