Micro-environment alterations through time leading to myeloid malignancies.

ageing bone marrow microenvironment haematopoiesis

Journal

British journal of pharmacology

ISSN: 1476-5381

Titre abrégé: Br J Pharmacol

Pays: England

ID NLM: 7502536

Informations de publication

Date de publication:
18 Jul 2022

Historique:

revised: 22 03 2022

received: 04 11 2021

accepted: 30 06 2022

pubmed: 19 7 2022

medline: 19 7 2022

entrez: 18 7 2022

Statut: aheadofprint

Résumé

The micro-environment plays a critical role in haematopoietic stem cell (HSC) development, self-renewal, differentiation and maintenance by providing a supportive cellular framework and essential molecular cues to sustain homeostasis. In ageing and development of age-related clonal haematopoiesis, the combined contribution of intrinsic alterations in haematopoietic stem cells and their surrounding micro-environment can promote myeloid skewing and release of pro-inflammatory cytokines. A pro-inflammatory micro-environment is a common feature in the initiation and sustenance of several myeloid malignancies. Furthermore, remodelling of the micro-environment is recognized to potentiate the survival of malignant over normal cells. This review explores micro-environmental interactions in the haematopoietic system of adults, especially how the bone marrow micro-environment is impacted by ageing, the onset of age-related clonal haematopoiesis and the development of myeloid malignancies. In addition, we also discuss the possible role age-related clonal haematopoiesis and chronic inflammatory conditions play in altering the bone marrow micro-environment dynamics. Finally, we explore the importance of in vitro models that accurately mimic different aspects of the bone marrow micro-environment in order to study normal and malignant haematopoiesis.

Identifiants

DOI: 10.1111/bph.15924 PMID: 35844165

pubmed: 35844165

doi: 10.1111/bph.15924

doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : Helen Higgins Bequest

Informations de copyright

Références

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