Ibuprofen Alleviates Acute Pancreatitis- (AP-) Induced Myocardial Injury by Inhibiting AIM2.
Journal
Computational and mathematical methods in medicine
ISSN: 1748-6718
Titre abrégé: Comput Math Methods Med
Pays: United States
ID NLM: 101277751
Informations de publication
Date de publication:
2022
2022
Historique:
received:
05
03
2022
accepted:
08
04
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
20
7
2022
Statut:
epublish
Résumé
The lack of certain trace elements such as selenium, molybdenum, magnesium or related nutrients in the soil, water quality and food in the disease area, which caused disturbance of myocardium metabolism and resulted in injury and necrosis. The aim of the study was to explore the mechanism of ibuprofen alleviating myocardial injury caused by acute pancreatitis (AP). We have established AP cell model and rat model. HE staining is used for histological examination. ELISA is used to determine the levels of proinflammatory cytokines (TNF- The expression level of AIM2 was significantly increased in AP cells; downregulation of AIM2 alleviated inflammation and myocardial injury induced by AP cells; ibuprofen could inhibit the expression of AIM2 and alleviate inflammation and myocardial injury induced by AP cells. In vivo experiments have found that ibuprofen can inhibit the expression of AIM2 to alleviate myocardial injury in AP rat. Ibuprofen can alleviate myocardial injury caused by acute pancreatitis by inhibiting the expression of AIM2.
Identifiants
pubmed: 35844444
doi: 10.1155/2022/8801484
pmc: PMC9286933
doi:
Substances chimiques
AIM2 protein, rat
0
DNA-Binding Proteins
0
Tumor Necrosis Factor-alpha
0
Ibuprofen
WK2XYI10QM
Types de publication
Journal Article
Retracted Publication
Langues
eng
Sous-ensembles de citation
IM
Pagination
8801484Commentaires et corrections
Type : RetractionIn
Informations de copyright
Copyright © 2022 Ke Chen and Shaohua Wang.
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests.
Références
Free Radic Biol Med. 2020 Aug 1;155:69-80
pubmed: 32445866
Q J Med. 1983 Summer;52(207):289-96
pubmed: 6359225
Br J Pharmacol. 2018 Jan;175(2):335-347
pubmed: 28542719
Cell Cycle. 2020 Jul;19(13):1665-1676
pubmed: 32449438
Mol Med Rep. 2021 Nov;24(5):
pubmed: 34498715
PLoS One. 2021 Jan 25;16(1):e0242706
pubmed: 33493150
World J Gastroenterol. 2021 Aug 14;27(30):5019-5036
pubmed: 34497432
Drug Res (Stuttg). 2022 Jan;72(1):18-22
pubmed: 34416778
Ecotoxicol Environ Saf. 2021 Dec 1;225:112757
pubmed: 34509164
Pediatr Int. 2021 Feb;63(2):137-149
pubmed: 32745358
Cell Signal. 2021 Nov;87:110141
pubmed: 34487815
Mol Med Rep. 2020 Jun;21(6):2615-2623
pubmed: 32323789
Pancreatology. 2017 May - Jun;17(3):364-371
pubmed: 28342645
Med Sci Monit. 2017 Nov 27;23:5650-5656
pubmed: 29176547
J Vis Exp. 2021 Jun 28;(172):
pubmed: 34251363
Chemosphere. 2022 Jan;286(Pt 3):131849
pubmed: 34426267