DNA minicircles as novel STAT3 decoy oligodeoxynucleotides endowed with anticancer activity in triple-negative breast cancer.
DNA minicircle
MT: Oligonucleotides: Therapies and Applications
STAT3
breast cancer
decoy
therapeutic oligonucleotide
transcription factor
Journal
Molecular therapy. Nucleic acids
ISSN: 2162-2531
Titre abrégé: Mol Ther Nucleic Acids
Pays: United States
ID NLM: 101581621
Informations de publication
Date de publication:
13 Sep 2022
13 Sep 2022
Historique:
received:
13
01
2022
accepted:
15
06
2022
entrez:
18
7
2022
pubmed:
19
7
2022
medline:
19
7
2022
Statut:
epublish
Résumé
Decoy technology is a versatile and specific DNA oligonucleotide-based targeting strategy of pathogenic transcription factors (TFs). Chemical modifications of linear decoy oligonucleotides have been made to decrease nuclease sensitivity because of the presence of free ends but at the cost of new limitations that affect their use as therapeutic drugs. Although a short DNA minicircle is a phosphodiester nucleic acid without free ends, its potential therapeutic activity as a TF decoy oligonucleotide has not yet been investigated. Here we describe the
Identifiants
pubmed: 35847174
doi: 10.1016/j.omtn.2022.06.012
pii: S2162-2531(22)00164-0
pmc: PMC9263874
doi:
Types de publication
Journal Article
Langues
eng
Pagination
162-175Informations de copyright
© 2022 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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