Interleukin-7 regulates CD127 expression and promotes CD8

CD8-Positive T-Lymphocytes Humans Interleukin-7 / metabolism Interleukin-7 Receptor alpha Subunit / metabolism Melanoma / metabolism Phosphatidylinositol 3-Kinases RNA, Messenger / metabolism Skin Neoplasms / metabolism Melanoma, Cutaneous Malignant
CD127 CD8+ T lymphocytes Immune regulation Interleukin-7 Melanoma

Journal

BMC immunology
ISSN: 1471-2172
Titre abrégé: BMC Immunol
Pays: England
ID NLM: 100966980

Informations de publication

Date de publication:
18 07 2022
Historique:
received: 29 12 2021
accepted: 06 07 2022
entrez: 19 7 2022
pubmed: 20 7 2022
medline: 22 7 2022
Statut: epublish

Résumé

Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8 Healthy controls and primary cutaneous melanoma patients were enrolled. Membrane-bound CD127 (mCD127) expression on CD8 Plasma sCD127 was lower in melanoma patients compared with controls. The percentage of CD8 The current data suggested that insufficient IL-7 secretion might contribute to CD8

Sections du résumé

BACKGROUND
Interleukin (IL)-7 signaling through CD127 is impaired in lymphocytes in cancers and chronic infections, resulting in CD8
METHODS
Healthy controls and primary cutaneous melanoma patients were enrolled. Membrane-bound CD127 (mCD127) expression on CD8
RESULTS
Plasma sCD127 was lower in melanoma patients compared with controls. The percentage of CD8
CONCLUSION
The current data suggested that insufficient IL-7 secretion might contribute to CD8

Identifiants

DOI: 10.1186/s12865-022-00509-0 PMID: 35850640 PMC: PMC9295418
pubmed: 35850640
doi: 10.1186/s12865-022-00509-0
pii: 10.1186/s12865-022-00509-0
pmc: PMC9295418
doi:

Substances chimiques

IL7R protein, human 0
Interleukin-7 0
Interleukin-7 Receptor alpha Subunit 0
RNA, Messenger 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

35

Informations de copyright

© 2022. The Author(s).

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Auteurs

Hongxia He (H)

Department of Dermatology, The First Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030000, Shanxi, China. fwxz2019@163.com.

Binjun Qiao (B)

Department of Emergency, The First Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China.

Shuping Guo (S)

Department of Dermatology, The First Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030000, Shanxi, China.

Hongzhou Cui (H)

Department of Dermatology, The First Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030000, Shanxi, China.

Ziyan Zhang (Z)

Department of Dermatology, The First Hospital of Shanxi Medical University, 85 South Jiefang Road, Taiyuan, 030000, Shanxi, China.

Junxia Qin (J)

Department of Dermatology, The Affiliated Shanxi Provincial People's Hospital of Shanxi Medical University, Taiyuan, 030000, Shanxi, China.

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Classifications MeSH

questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-7 › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-7 › Sous-unité alpha du récepteur à l'interleukine-7 › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Naevus et mélanomes › Mélanome › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Phosphatidylinositol 3-kinases › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Interleukin-7 regulates CD127 expression and...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › Interleukin-7 regulates CD127 expression and...