Renal inflamm-aging provokes intra-graft inflammation following experimental kidney transplantation.
inflamm-aging
kidney transplantation
senescence
senolytic drug
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
11 2022
11 2022
Historique:
revised:
14
06
2022
received:
08
11
2021
accepted:
14
07
2022
pubmed:
20
7
2022
medline:
10
11
2022
entrez:
19
7
2022
Statut:
ppublish
Résumé
Donor age is a major risk factor for allograft outcome in kidney transplantation. The underlying cellular mechanisms and the recipient's immune response within an aged allograft have yet not been analyzed. A comprehensive immunophenotyping of naïve and transplanted young versus aged kidneys revealed that naïve aged murine kidneys harbor significantly higher frequencies of effector/memory T cells, whereas regulatory T cells were reduced. Aged kidney-derived CD8
Identifiants
pubmed: 35851547
doi: 10.1111/ajt.17154
pii: S1600-6135(22)29970-5
doi:
Substances chimiques
navitoclax
XKJ5VVK2WD
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2529-2547Informations de copyright
© 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
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