Sirtuin 5 levels are limiting in preserving cardiac function and suppressing fibrosis in response to pressure overload.

Animals Cardiomegaly / metabolism Disease Models, Animal Fibrosis Heart Failure Mice Mice, Inbred C57BL Myocardium / metabolism Sirtuins / metabolism Ventricular Remodeling

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
18 07 2022
Historique:
received: 24 12 2021
accepted: 11 07 2022
entrez: 19 7 2022
pubmed: 20 7 2022
medline: 22 7 2022
Statut: epublish

Résumé

Heart failure (HF) is the inability of the heart to pump blood sufficiently to meet the metabolic demands of the body. HF with reduced systolic function is characterized by cardiac hypertrophy, ventricular fibrosis and remodeling, and decreased cardiac contractility, leading to cardiac functional impairment and death. Transverse aortic constriction (TAC) is a well-established model for inducing hypertrophy and HF in rodents. Mice globally deficient in sirtuin 5 (SIRT5), a NAD

Identifiants

DOI: 10.1038/s41598-022-16506-7 PMID: 35851833 PMC: PMC9293976
pubmed: 35851833
doi: 10.1038/s41598-022-16506-7
pii: 10.1038/s41598-022-16506-7
pmc: PMC9293976
doi:

Substances chimiques

SIRT5 protein, mouse 0
Sirtuins EC 3.5.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

12258

Subventions

Organisme : NIA NIH HHS
ID : R37AG028730
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32GM113900
Pays : United States
Organisme : NCI NIH HHS
ID : R01CA248160
Pays : United States
Organisme : NIA NIH HHS
ID : T32AG000114
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA244931
Pays : United States
Organisme : NIGMS NIH HHS
ID : R25GM086262
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM101171
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA046592
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL136695
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01GM101171
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00HL136695
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21ES032305
Pays : United States

Informations de copyright

© 2022. The Author(s).

Références

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Auteurs

Angela H Guo (AH)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.
Molecular and Cellular Pathology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.

Rachael Baliira (R)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Mary E Skinner (ME)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Surinder Kumar (S)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Anthony Andren (A)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.

Li Zhang (L)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.

Robert S Goldsmith (RS)

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Pharmacology Graduate Program, University of Michigan, Ann Arbor, MI, 48109, USA.

Shaday Michan (S)

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.
Rejuvenate Bio Inc, San Diego, CA, 92121, USA.

Norma J Davis (NJ)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Merissa W Maccani (MW)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA.

Sharlene M Day (SM)

Division of Cardiovascular Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

David A Sinclair (DA)

Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA.

Matthew J Brody (MJ)

Department of Pharmacology, University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

Costas A Lyssiotis (CA)

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA.
Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA.

Adam B Stein (AB)

Department of Internal Medicine, University of Michigan, Ann Arbor, MI, 48109, USA.

David B Lombard (DB)

Department of Pathology, University of Michigan, Ann Arbor, MI, 48109, USA. dbl68@miami.edu.
Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 48109, USA. dbl68@miami.edu.
Institute of Gerontology, University of Michigan, Ann Arbor, MI, 48109, USA. dbl68@miami.edu.
Department of Pathology and Laboratory Medicine, University of Miami Miller School of Medicine, 708 Biomedical Research Building, 1501 NW 10th Avenue, Miami, FL, 33136, USA. dbl68@miami.edu.
Sylvester Comprehensive Cancer Center, Miami, FL, 33136, USA. dbl68@miami.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Fibrose › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Maladies cardiovasculaires › Cardiopathies › Défaillance cardiaque › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Sirtuines › Sirtuin 5 levels are limiting in preserving...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Fonction ventriculaire › Remodelage ventriculaire › Sirtuin 5 levels are limiting in preserving...