Microglia deficiency accelerates prion disease but does not enhance prion accumulation in the brain.

Animals Astrocytes / metabolism Brain / metabolism Mice Microglia / metabolism Prion Diseases / metabolism Prions / genetics
central nervous system microglia neurodegeneration prion disease reactive astrocyte

Journal

Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785

Informations de publication

Date de publication:
11 2022
Historique:
revised: 24 06 2022
received: 05 04 2022
accepted: 30 06 2022
pubmed: 20 7 2022
medline: 15 9 2022
entrez: 19 7 2022
Statut: ppublish

Résumé

Prion diseases are transmissible, neurodegenerative disorders associated with misfolding of the prion protein. Previous studies show that reduction of microglia accelerates central nervous system (CNS) prion disease and increases the accumulation of prions in the brain, suggesting that microglia provide neuroprotection by phagocytosing and destroying prions. In Csf1r

Identifiants

DOI: 10.1002/glia.24244 PMID: 35852018 PMC: PMC9544114
pubmed: 35852018
doi: 10.1002/glia.24244
pmc: PMC9544114
doi:

Substances chimiques

Prions 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2169-2187

Subventions

Organisme : Medical Research Council
ID : MR/M019969/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/S005471/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/20002173
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BBS/E/D/10002071
Pays : United Kingdom

Informations de copyright

© 2022 The Authors. GLIA published by Wiley Periodicals LLC.

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Auteurs

Barry M Bradford (BM)

The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK.

Lynne I McGuire (LI)

The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK.

David A Hume (DA)

Mater Research Institute-University of Queensland, Translational Research Institute, Woolloongabba, Queensland, Australia.

Clare Pridans (C)

Simons Initiative for the Developing Brain, Centre for Discovery Brain Sciences, University of Edinburgh, Hugh Robson Building, Edinburgh, UK.
Centre for Inflammation Research, The Queen's Medical Research Institute, Edinburgh BioQuarter, Edinburgh, UK.

Neil A Mabbott (NA)

The Roslin Institute and R(D)SVS, University of Edinburgh, Easter Bush Campus, Midlothian, UK.
ORCID: 0000-0001-7395-1796

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Cellules › Névroglie › Microglie › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Maladies à prions › Microglia deficiency accelerates prion disease...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Prions › Microglia deficiency accelerates prion disease...