Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease.
2-oxoglutarate/alpha-ketoglutarate dependent oxygenases
Alzheimer's disease
JmjC demethylases
epigenetics
hydroxylases
hypoxia-inducible factor
synapse loss
Journal
Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
revised:
12
05
2022
received:
19
01
2022
accepted:
10
06
2022
pubmed:
20
7
2022
medline:
3
1
2023
entrez:
19
7
2022
Statut:
ppublish
Résumé
Hypoxia, that is, an inadequate oxygen supply, is linked to neurodegeneration and patients with cardiovascular disease are prone to Alzheimer's disease (AD). 2-Oxoglutarate and ferrous iron-dependent oxygenases (2OGDD) play a key role in the regulation of oxygen homeostasis by acting as hypoxia sensors. 2OGDD also have roles in collagen biosynthesis, lipid metabolism, nucleic acid repair, and the regulation of transcription and translation. Many biological processes in which the >60 human 2OGDD are involved are altered in AD patient brains, raising the question as to whether 2OGDD are involved in the transition from normal aging to AD. Here we give an overview of human 2OGDD and critically discuss their potential roles in AD, highlighting possible relationships with synapse dysfunction/loss. 2OGDD may regulate neuronal/glial differentiation through enzyme activity-dependent mechanisms and modulation of their activity has potential to protect against synapse loss. Work linking 2OGDD and AD is at an early stage, especially from a therapeutic perspective; we suggest integrated pathology and in vitro discovery research to explore their roles in AD is merited. We hope to help enable long-term research on the roles of 2OGDD and, more generally, oxygen/hypoxia in AD. We also suggest shorter term empirically guided clinical studies concerning the exploration of 2OGDD/oxygen modulators to help maintain synaptic viability are of interest for AD treatment.
Identifiants
pubmed: 35852137
doi: 10.1002/alz.12733
pmc: PMC10083964
doi:
Substances chimiques
Oxygenases
EC 1.13.-
Ketoglutaric Acids
0
Oxygen
S88TT14065
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2637-2668Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 106244/Z/14/Z
Pays : United Kingdom
Informations de copyright
© 2022 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
Références
Nat Neurosci. 2014 Mar;17(3):357-66
pubmed: 24464041
J Biol Chem. 2015 Aug 21;290(34):20734-20742
pubmed: 26152727
Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21623-8
pubmed: 21115819
Neurosci Bull. 2019 Apr;35(2):179-182
pubmed: 30843142
Alzheimers Res Ther. 2020 Mar 2;12(1):21
pubmed: 32122400
Am J Med Genet B Neuropsychiatr Genet. 2013 Dec;162B(8):789-99
pubmed: 24038819
Free Radic Biol Med. 2019 Mar;133:221-233
pubmed: 30266679
Neurochem Res. 1995 Jun;20(6):705-11
pubmed: 7566367
Alzheimers Dement. 2020 Mar 10;:
pubmed: 32157811
Mech Ageing Dev. 2013 Oct;134(10):486-95
pubmed: 24012631
J Biol Chem. 2014 Oct 3;289(40):27924-36
pubmed: 25122757
J Biol Chem. 2011 Sep 23;286(38):33061-9
pubmed: 21757686
Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7565-73
pubmed: 21873682
J Biol Chem. 2014 Jun 20;289(25):17299-311
pubmed: 24778178
J Cell Biochem. 2012 May;113(5):1663-70
pubmed: 22189873
J Korean Med Sci. 2019 Aug 26;34(33):e225
pubmed: 31436053
J Biol Chem. 2014 Apr 25;289(17):11571-11583
pubmed: 24616105
J Alzheimers Dis. 2021;80(3):949-961
pubmed: 33612545
Neurosci Lett. 1988 Sep 12;91(3):259-64
pubmed: 2972943
Nature. 2006 Feb 16;439(7078):811-6
pubmed: 16362057
Brain. 2019 Mar 1;142(3):787-807
pubmed: 30668640
Mol Cell. 2011 May 6;42(3):330-41
pubmed: 21549310
Proc Natl Acad Sci U S A. 2009 Oct 27;106(43):18367-72
pubmed: 19837693
Nat Rev Mol Cell Biol. 2014 May;15(5):313-26
pubmed: 24713629
Nat Commun. 2020 Mar 9;11(1):1313
pubmed: 32152318
Alzheimers Dement. 2018 Feb;14(2):215-229
pubmed: 28923553
Science. 2007 Oct 19;318(5849):444-7
pubmed: 17947579
J Neurochem. 2002 Mar;80(5):727-35
pubmed: 11948235
Physiol Genomics. 2006 May 16;25(3):435-49
pubmed: 16507782
Alzheimers Dement. 2020 Feb;16(2):345-353
pubmed: 31786126
Mol Psychiatry. 2020 Jan;25(1):148-167
pubmed: 31391546
J Biol Chem. 2019 Dec 13;294(50):19424-19435
pubmed: 31699893
Cell Rep. 2014 Sep 11;8(5):1290-9
pubmed: 25176653
J Neurochem. 2019 Jul;150(2):113-137
pubmed: 30802950
Nat Commun. 2019 Oct 28;10(1):4910
pubmed: 31659163
J Biol Chem. 2012 Jan 13;287(3):2130-43
pubmed: 22065580
Mol Neurobiol. 2019 Aug;56(8):5436-5455
pubmed: 30612333
J Cell Mol Med. 2009 Mar;13(3):508-21
pubmed: 18298658
Hum Mol Genet. 2020 Jul 21;29(11):1833-1852
pubmed: 31943063
Am J Hum Genet. 2008 Oct;83(4):495-503
pubmed: 18834968
PLoS One. 2013 Jun 25;8(6):e67403
pubmed: 23825659
Mol Cell. 2012 Nov 30;48(4):491-507
pubmed: 23200123
J Clin Endocrinol Metab. 2015 Jan;100(1):E148-54
pubmed: 25303482
J Neurochem. 2010 Jan;112(1):1-12
pubmed: 19845827
Biochem Biophys Res Commun. 2022 Apr 30;602:156-162
pubmed: 35276556
Curr Neuropharmacol. 2019;17(11):1071-1095
pubmed: 31161981
Brain Behav Immun. 2011 Mar;25(3):539-47
pubmed: 21167930
Neurobiol Aging. 2014 Jan;35(1):64-71
pubmed: 23969178
Arch Neurol. 2005 Oct;62(10):1556-60
pubmed: 16216938
Matrix Biol. 2003 Mar;22(1):15-24
pubmed: 12714038
FEBS Lett. 2008 Oct 15;582(23-24):3313-9
pubmed: 18775698
FASEB J. 2020 Dec;34(12):16364-16382
pubmed: 33058355
Scand J Clin Lab Invest. 1982 Oct;42(6):477-85
pubmed: 7156861
Alcohol Clin Exp Res. 2017 Dec;41(12):2015-2024
pubmed: 28940624
Neuropathol Appl Neurobiol. 2006 Apr;32(2):119-30
pubmed: 16599941
J Alzheimers Dis. 2013;34(2):399-405
pubmed: 23234877
Exp Neurol. 1973 Jul;40(1):114-25
pubmed: 4714036
J Nutr Health Aging. 2015 Jan;19(1):58-63
pubmed: 25560817
Biochem Biophys Res Commun. 2011 May 20;408(4):553-8
pubmed: 21530488
EMBO J. 2016 Oct 4;35(19):2104-2119
pubmed: 27497299
Nat Struct Mol Biol. 2010 Jan;17(1):38-43
pubmed: 20023638
Annu Rev Biochem. 2018 Jun 20;87:585-620
pubmed: 29494239
J Mol Cell Biol. 2013 Jun;5(3):194-203
pubmed: 23572141
Redox Biol. 2020 May;32:101494
pubmed: 32199332
Mol Cell Biol. 2010 May;30(10):2449-59
pubmed: 20308323
J Cell Biochem. 2014 Sep;115(9):1528-38
pubmed: 24619877
J Biol Chem. 2008 Jul 11;283(28):19432-9
pubmed: 18487197
Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1261-6
pubmed: 19164591
Neurobiol Aging. 2015 Dec;36(12):3121-3129
pubmed: 26553823
Nat Commun. 2016 Jun 23;7:11974
pubmed: 27337104
Chem Commun (Camb). 2014 Feb 21;50(15):1794-6
pubmed: 24287551
Nat Rev Mol Cell Biol. 2008 Apr;9(4):285-96
pubmed: 18285802
Nat Rev Genet. 2006 Sep;7(9):715-27
pubmed: 16983801
Genet Med. 2019 Oct;21(10):2355-2363
pubmed: 30940925
Cell. 2016 Nov 3;167(4):897-914
pubmed: 27814520
J Virol. 2009 Dec;83(23):12009-17
pubmed: 19759154
J Alzheimers Dis. 2011;23(3):461-9
pubmed: 21098976
Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7175-80
pubmed: 17438271
Neurobiol Dis. 2021 Jan;147:105145
pubmed: 33127469
Biol Chem. 2013 Apr;394(4):435-48
pubmed: 23324380
Development. 2021 Jun 15;148(12):
pubmed: 34081130
J Biol Chem. 2019 May 10;294(19):7917-7930
pubmed: 30936201
Immunity. 2014 Jun 19;40(6):865-79
pubmed: 24856900
Hum Mol Genet. 2007 Jan 1;16(1):15-23
pubmed: 17135279
J Biol Chem. 2005 Nov 25;280(47):39448-59
pubmed: 16174769
Nat Rev Mol Cell Biol. 2004 May;5(5):343-54
pubmed: 15122348
Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4031-6
pubmed: 24550447
Am J Pathol. 2020 Aug;190(8):1584-1595
pubmed: 32339495
Nat Commun. 2018 Oct 26;9(1):4456
pubmed: 30367042
Acta Neuropathol. 2011 Sep;122(3):271-83
pubmed: 21594711
Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14767-72
pubmed: 17003112
Chemistry. 2020 Sep 21;26(53):12101-12110
pubmed: 32207199
Genes Dev. 2013 May 15;27(10):1089-100
pubmed: 23666923
J Neurochem. 2021 Sep;158(5):1032-1057
pubmed: 34278579
Aging Dis. 2016 Mar 15;7(2):180-200
pubmed: 27114850
Trends Endocrinol Metab. 2018 Apr;29(4):249-259
pubmed: 29501229
Nature. 2003 Feb 20;421(6925):859-63
pubmed: 12594517
J Biol Chem. 2011 Sep 30;286(39):34088-100
pubmed: 21832049
Proc Natl Acad Sci U S A. 2010 May 25;107(21):9671-6
pubmed: 20457893
Blood. 2014 Sep 25;124(13):e21-32
pubmed: 25097177
J Biol Chem. 2002 Jun 21;277(25):23084-91
pubmed: 11956192
J Biol Chem. 2016 Sep 23;291(39):20661-73
pubmed: 27502280
PLoS One. 2017 Jan 18;12(1):e0170345
pubmed: 28099462
PLoS One. 2014 Jan 07;9(1):e84767
pubmed: 24409307
Nature. 2015 Sep 17;525(7569):389-393
pubmed: 26287468
Mol Cell Biol. 2010 Apr;30(8):2006-16
pubmed: 20154146
Science. 2019 Mar 15;363(6432):1222-1226
pubmed: 30872526
Stem Cell Reports. 2018 Apr 10;10(4):1193-1207
pubmed: 29551674
J Biol Chem. 2013 Apr 12;288(15):10819-29
pubmed: 23423382
Nat Commun. 2020 Jan 20;11(1):382
pubmed: 31959746
Adv Chronic Kidney Dis. 2019 Jul;26(4):253-266
pubmed: 31477256
Neuron. 2008 Dec 26;60(6):988-1009
pubmed: 19109907
Ageing Res Rev. 2021 Jul;68:101343
pubmed: 33862277
Am J Physiol Regul Integr Comp Physiol. 2014 Nov 15;307(10):R1181-97
pubmed: 25231353
Cell Stem Cell. 2012 Jun 14;10(6):657-659
pubmed: 22704503
Sci Rep. 2016 Sep 27;6:34125
pubmed: 27671354
PLoS One. 2014 Feb 03;9(2):e87982
pubmed: 24498420
Int J Biochem Cell Biol. 2015 Oct;67:148-57
pubmed: 26193001
Oxid Med Cell Longev. 2010 Sep-Oct;3(5):347-56
pubmed: 21150341
NeuroRx. 2004 Jan;1(1):26-35
pubmed: 15717005
Nat Rev Neurosci. 2011 Nov 03;12(12):723-38
pubmed: 22048062
Cell Rep. 2021 May 11;35(6):109121
pubmed: 33979625
J Mol Cell Cardiol. 2006 Jul;41(1):68-77
pubmed: 16765982
J Neurochem. 2021 May;157(3):656-665
pubmed: 32797675
Front Aging Neurosci. 2018 Feb 23;10:41
pubmed: 29527164
Nat Med. 2008 Jun;14(6):681-7
pubmed: 18516051
Cancer Discov. 2020 Nov;10(11):1706-1721
pubmed: 32690540
Alzheimers Dement. 2014 Nov;10(6):637-645.e1
pubmed: 24656848
Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16660-5
pubmed: 12486230
Crit Rev Biochem Mol Biol. 2004 Jan-Feb;39(1):21-68
pubmed: 15121720
Alzheimers Dement. 2022 Dec;18(12):2637-2668
pubmed: 35852137
J Mol Biol. 2010 Aug 13;401(2):211-22
pubmed: 20684070
J Biol Chem. 2015 Aug 21;290(34):20712-20722
pubmed: 26152730
Alzheimers Dement. 2021 Mar;17(3):327-406
pubmed: 33756057
Ann N Y Acad Sci. 2009 Oct;1177:9-18
pubmed: 19845602
PLoS One. 2010 Oct 29;5(10):e13769
pubmed: 21060799
Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):E7717-E7726
pubmed: 28847961
Adv Protein Chem Struct Biol. 2015;101:125-48
pubmed: 26572978
Genes Dev. 2002 Jun 15;16(12):1466-71
pubmed: 12080085
Brain Sci. 2020 Nov 09;10(11):
pubmed: 33182385
Angew Chem Int Ed Engl. 2021 Jun 21;60(26):14657-14663
pubmed: 33887099
Int J Mol Sci. 2016 Oct 10;17(10):
pubmed: 27735865
Mol Biol Cell. 2004 Apr;15(4):1816-32
pubmed: 14742713
Matrix Biol. 2000 Feb;19(1):37-46
pubmed: 10686424
Neurotox Res. 2010 May;17(4):360-79
pubmed: 19760337
Int J Biochem Cell Biol. 2005 Apr;37(4):775-83
pubmed: 15694837
Exp Neurol. 2016 Dec;286:93-106
pubmed: 27720797
Prog Neurobiol. 2015 Aug;131:1-20
pubmed: 26001589
Neuroscience. 2001;104(3):653-65
pubmed: 11440799
Front Neurosci. 2020 Feb 28;14:98
pubmed: 32184705
Gene. 2011 Apr 1;475(1):1-9
pubmed: 21145952
J Biol Chem. 2000 Jun 23;275(25):18724-31
pubmed: 10751411
FEBS J. 2022 Dec;289(24):7776-7787
pubmed: 34536985
Vaccine. 2015 Mar 3;33(10):1256-66
pubmed: 25629522
Epigenomics. 2014 Feb;6(1):89-120
pubmed: 24579949
J Biol Chem. 2007 Aug 17;282(33):24027-38
pubmed: 17573339
PLoS One. 2012;7(12):e52417
pubmed: 23251711
Sci Rep. 2017 Dec 19;7(1):17762
pubmed: 29259249
Chemosphere. 2020 Apr;244:125445
pubmed: 31835052
Transl Psychiatry. 2014 Jun 10;4:e396
pubmed: 26126179
Cells. 2019 May 08;8(5):
pubmed: 31072055
Cell. 2016 Oct 20;167(3):816-828.e16
pubmed: 27745969
Hum Mutat. 2012 Mar;33(3):521-9
pubmed: 22190428
Blood. 2012 Oct 18;120(16):3336-44
pubmed: 22955912
Nat Rev Neurosci. 2019 Mar;20(3):148-160
pubmed: 30737462
Elife. 2021 Mar 17;10:
pubmed: 33729157
Protein Sci. 2019 Aug;28(8):1387-1399
pubmed: 31095801
Nat Chem Biol. 2011 Oct 16;7(12):885-7
pubmed: 22002720
Int J Mol Sci. 2015 Dec 21;16(12):30483-543
pubmed: 26703582
Curr Alzheimer Res. 2019;16(7):596-612
pubmed: 31345147
J Biol Chem. 2009 Oct 30;284(44):30350-9
pubmed: 19726677
J Neurochem. 2005 Oct;95(1):68-78
pubmed: 16181413
J Clin Invest. 2017 Sep 1;127(9):3240-3249
pubmed: 28862638
Genes Dev. 2016 Apr 1;30(7):733-50
pubmed: 27036965
Front Cell Dev Biol. 2018 Jun 28;6:66
pubmed: 30003082
Prog Neurobiol. 2010 Apr;90(4):498-510
pubmed: 20097254
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2018 May;34(5):434-441
pubmed: 30043735
J Biol Chem. 2010 Nov 5;285(45):34503-7
pubmed: 20739293
Prog Neurobiol. 2017 Sep;156:189-213
pubmed: 28587768
Nat Med. 2019 Apr;25(4):554-560
pubmed: 30911133
Nat Chem Biol. 2018 Jul;14(7):688-695
pubmed: 29915238
Neurochem Res. 2017 Jun;42(6):1661-1675
pubmed: 28508995
Mol Cell. 2014 Feb 20;53(4):645-54
pubmed: 24486019
J Biol Chem. 2020 Jun 5;295(23):7826-7838
pubmed: 32107312
Mol Cell. 2013 Jan 10;49(1):18-29
pubmed: 23177736
Nat Neurosci. 2013 Sep;16(9):1299-305
pubmed: 23933749
Cell Rep. 2014 Aug 21;8(4):1077-92
pubmed: 25131208
J Alzheimers Dis. 2015;47(2):373-83
pubmed: 26401560
Brain Behav Immun. 2019 Jul;79:159-173
pubmed: 30763768
J Alzheimers Dis. 2012;29(2):241-54
pubmed: 22433776
Nat Commun. 2018 Mar 21;9(1):1180
pubmed: 29563586
Am J Physiol Cell Physiol. 2007 Feb;292(2):C641-57
pubmed: 17092996
Matrix Biol. 2002 Nov;21(7):559-66
pubmed: 12475640
Cell Res. 2010 Aug;20(8):908-18
pubmed: 20548336
Nat Commun. 2011 Feb 01;2:172
pubmed: 21285950
Biochim Biophys Acta Rev Cancer. 2019 Apr;1871(2):406-418
pubmed: 31034925
Nat Commun. 2013;4:1832
pubmed: 23673617
Neurochem Int. 2011 Nov;59(6):880-8
pubmed: 21854819
Mol Neurodegener. 2014 Nov 14;9:48
pubmed: 25394486
Antioxid Redox Signal. 2008 Dec;10(12):1989-98
pubmed: 18774900
J Biol Chem. 2007 Oct 19;282(42):30544-52
pubmed: 17726031
J Biol Chem. 2002 Jul 19;277(29):26351-5
pubmed: 12042299
Neuroreport. 2002 Dec 20;13(18):2429-32
pubmed: 12499843
Nat Chem Biol. 2012 Dec;8(12):960-962
pubmed: 23103944
Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):279-84
pubmed: 24344305
Cell Cycle. 2009 Jul 1;8(13):2101-9
pubmed: 19502796
Neurobiol Aging. 2013 Sep;34(9):2081-90
pubmed: 23582659
Arch Pharm Res. 2019 May;42(5):393-406
pubmed: 30739266
EMBO Rep. 2017 Dec;18(12):2131-2143
pubmed: 28982940
Alzheimers Res Ther. 2019 Nov 28;11(1):93
pubmed: 31779690
Biochim Biophys Acta Mol Cell Res. 2019 Sep;1866(9):1463-1474
pubmed: 31199931
Brief Funct Genomics. 2015 May;14(3):169-79
pubmed: 25305461
J Am Soc Nephrol. 2020 Mar;31(3):501-516
pubmed: 31996410
Alzheimers Dement. 2021 Jul;17(7):1244-1256
pubmed: 33491917
J Biol Chem. 2008 Sep 5;283(36):25046-56
pubmed: 18603530
J Am Geriatr Soc. 2005 Jul;53(7):1101-7
pubmed: 16108925
Cell Rep. 2019 Oct 15;29(3):697-713.e8
pubmed: 31618637
Exp Neurobiol. 2010 Jun;19(1):1-14
pubmed: 22110336
Biochem J. 2013 Jun 15;452(3):509-18
pubmed: 23577621
Chem Sci. 2017 Nov 1;8(11):7651-7668
pubmed: 29435217
J Med Genet. 2008 Dec;45(12):787-93
pubmed: 18697827
J Invest Dermatol. 2005 May;124(5):914-8
pubmed: 15854030
Arterioscler Thromb Vasc Biol. 2016 Jul;36(7):1425-33
pubmed: 27199445
Sci Rep. 2018 Feb 19;8(1):3275
pubmed: 29459673
Life Sci. 2015 Sep 1;136:108-19
pubmed: 26159898
Nat Commun. 2021 Sep 1;12(1):5220
pubmed: 34471104
Antioxid Redox Signal. 2010 Apr;12(4):435-43
pubmed: 19659431
J Neuroinflammation. 2019 Apr 5;16(1):74
pubmed: 30953557
Resuscitation. 2013 Mar;84(3):351-6
pubmed: 22885094
Synapse. 2007 Sep;61(9):741-7
pubmed: 17568411
Neurosci Bull. 2019 Apr;35(2):270-276
pubmed: 30411305
Proc Natl Acad Sci U S A. 1981 Sep;78(9):5722-3
pubmed: 6946511
J Biol Chem. 2005 Feb 11;280(6):4491-7
pubmed: 15561723
Epigenetics. 2021 Jan;16(1):14-27
pubmed: 32609604
Hum Mol Genet. 2014 Dec 1;23(23):6286-301
pubmed: 24990149
Science. 2019 Mar 15;363(6432):1217-1222
pubmed: 30872525
Alzheimers Dement. 2020 Jul;16(7):974-982
pubmed: 32400950
Neuroscience. 2019 Oct 15;418:15-24
pubmed: 31442565
Biochem Biophys Res Commun. 2016 Apr 8;472(3):551-6
pubmed: 26970303
Blood. 2016 Nov 24;128(21):2550-2560
pubmed: 27683416
Cell Rep. 2021 Feb 16;34(7):108753
pubmed: 33596422
Ann N Y Acad Sci. 2009 Oct;1177:169-77
pubmed: 19845619
Biochem J. 2008 Dec 15;416(3):387-94
pubmed: 18713068
J Biol Chem. 2012 Apr 13;287(16):12994-3004
pubmed: 22375008
Front Oncol. 2021 Mar 25;11:619300
pubmed: 33842321
Cell. 2014 Feb 27;156(5):1072-83
pubmed: 24561062
J Biol Chem. 1996 Apr 19;271(16):9398-402
pubmed: 8621606
J Mol Graph Model. 2014 Nov;54:123-30
pubmed: 25459764
Nat Commun. 2018 Nov 1;9(1):4563
pubmed: 30385828
Neurobiol Aging. 2011 Jul;32(7):1188-91
pubmed: 21497948
Front Aging Neurosci. 2022 Mar 22;14:830569
pubmed: 35391749
Biochem Biophys Res Commun. 2018 Mar 25;498(1):234-239
pubmed: 29501742
Biochem Biophys Res Commun. 2018 May 15;499(3):711-718
pubmed: 29605300
Angew Chem Int Ed Engl. 2010 Nov 15;49(47):8885-8
pubmed: 20583019
Nat Commun. 2018 Aug 8;9(1):3163
pubmed: 30089812
Cell. 2012 May 25;149(5):1060-72
pubmed: 22632970
PLoS One. 2007 Aug 01;2(8):e690
pubmed: 17668068
Int J Mol Epidemiol Genet. 2011;2(2):156-62
pubmed: 21686130
Cell Mol Life Sci. 2015 Oct;72(20):3897-914
pubmed: 26118662
PLoS One. 2011 Jan 14;6(1):e16210
pubmed: 21264265
Int J Geriatr Psychiatry. 1998 Nov;13(11):749-54
pubmed: 9850871
EMBO J. 2010 Jan 6;29(1):68-79
pubmed: 19927124
J Am Coll Cardiol. 2019 Jul 2;73(25):3326-3344
pubmed: 31248555
J Neurochem. 2017 Feb;140(4):536-549
pubmed: 27987381
Adv Drug Deliv Rev. 2003 Nov 28;55(12):1531-46
pubmed: 14623400
Neurosci Biobehav Rev. 2019 Jul;102:337-344
pubmed: 31078565
Hum Mol Genet. 2020 Jan 1;29(1):149-158
pubmed: 31814020
EMBO J. 2015 Jun 12;34(12):1687-703
pubmed: 25944111
Nat Rev Cancer. 2020 Dec;20(12):710-726
pubmed: 33087883
Acc Chem Res. 2019 Jul 16;52(7):2026-2035
pubmed: 31274278