Meconium-stained amniotic fluid during labor may be a protective factor for the offspring's childhood wheezing up to 3 years of age: the Japan Environment and Children's Study.
Birth cohort study
Childhood wheezing
Labor
Meconium-stained amniotic fluid
Perinatal outcome
Journal
European journal of pediatrics
ISSN: 1432-1076
Titre abrégé: Eur J Pediatr
Pays: Germany
ID NLM: 7603873
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
received:
25
11
2021
accepted:
12
06
2022
revised:
10
03
2022
pubmed:
20
7
2022
medline:
9
8
2022
entrez:
19
7
2022
Statut:
ppublish
Résumé
We aimed to evaluate the association between meconium-stained amniotic fluid during labor and offspring's childhood wheezing. This study analyzed the data of participants enrolled in the Japan Environment and Children's Study, a nationwide prospective birth cohort study, between 2011 and 2014. Data of women with singleton live births between 22 and 40 weeks' gestation were analyzed. Participants were categorized into two groups according to the presence or absence of meconium-stained amniotic fluid. The primary outcome measure was the offspring's childhood wheezing up to 3 years of age. A logistic regression model was used to calculate the adjusted odds ratio for childhood wheezing in children of women with meconium-stained amniotic fluid, considering those without meconium-stained amniotic fluid as a reference, taking into account the potential confounding factors affecting the incidence of wheezing. We analyzed data from 61,991 participants: 1796 (2.9%) participants had meconium-stained amniotic fluid during labor and 18,919 (30.5%) of the offspring had childhood wheezing. The adjusted odds ratios for the offspring's childhood wheezing were 0.89 (95% confidence interval, 0.79-0.99) in total participants, 0.87 (95% confidence interval, 0.78-0.97) in term births, and 2.00 (95% confidence interval, 0.98-4.09) in preterm births. This study revealed a decreased incidence of childhood wheezing among the children of women with meconium-stained amniotic fluid in term births. By yet unknown mechanisms, meconium-stained amniotic fluid was associated with a decreased incidence of childhood wheezing in the offspring. Further studies are required to clarify the mechanism of one's own meconium in affecting their health condition. • Meconium-stained amniotic fluid during labor is associated with several adverse perinatal outcomes, and meconium aspiration syndrome is associated with offspring's childhood asthma and wheezing. • Meconium-stained amniotic fluid during labor could be an independent protective factor for the offspring's dermatitis and skin rash. • Whole cases with meconium-stained amniotic fluid during labor were associated with a decreased incidence of offspring's childhood wheezing up to 3 years of age. • This study may shed light on the effects of simple meconium-stained amniotic fluid on offspring's childhood health.
Identifiants
pubmed: 35852596
doi: 10.1007/s00431-022-04530-8
pii: 10.1007/s00431-022-04530-8
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3153-3162Informations de copyright
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Références
Romero R, Yoon BH, Chaemsaithong P, Cortez J, Park CW, Gonzalez R, Behnke E, Hassan SS, Chaiworapongsa T, Yeo L (2014) Bacteria and endotoxin in meconium-stained amniotic fluid at term: could intra-amniotic infection cause meconium passage? J Matern Fetal Neonatal Med 27:775–788. https://doi.org/10.3109/14767058.2013.844124
doi: 10.3109/14767058.2013.844124
pubmed: 24028637
Caughey AB, Musci TJ (2004) Complications of term pregnancies beyond 37 weeks of gestation. Obstet Gynecol 103:14704245. https://doi.org/10.1097/01.AOG.0000109216.24211.D4
doi: 10.1097/01.AOG.0000109216.24211.D4
Balchin I, Whittaker JC, Lamont RF, Steer PJ (2011) Maternal and fetal characteristics associated with meconium-stained amniotic fluid. Obstet Gynecol 117:828–835. https://doi.org/10.1097/AOG.0b013e3182117a26
doi: 10.1097/AOG.0b013e3182117a26
pubmed: 21383642
Berkus MD, Langer O, Samueloff A, Xenakis EM, Field NT, Ridgway LE (1994) Meconium-stained amniotic fluid: increased risk for adverse neonatal outcome. Obstet Gynecol 84:8008304
Oyelese Y, Culin A, Ananth CV, Kaminsky LM, Vintzileos A, Smulian JC (2006) Meconium-stained amniotic fluid across gestation and neonatal acid–base status. Obstet Gynecol 108:16880305. https://doi.org/10.1097/01.AOG.0000226853.85609.8d
doi: 10.1097/01.AOG.0000226853.85609.8d
Ohana O, Holcberg G, Sergienko R, Sheiner E (2011) Risk factors for intrauterine fetal death (1988–2009. J Matern Fetal Neonatal Med 24:21314292. https://doi.org/10.3109/14767058.2010.545918
doi: 10.3109/14767058.2010.545918
Dargaville PA, Copnell B, Australian NNZN (2006) The epidemiology of meconium aspiration syndrome: incidence, risk factors, therapies, and outcome. Pediatrics 117:16651329. https://doi.org/10.1542/peds.2005-2215
doi: 10.1542/peds.2005-2215
Khazardoost S, Hantoushzadeh S, Khooshideh M, Borna S (2007) Risk factors for meconium aspiration in meconium stained amniotic fluid. J Obstet Gynaecol 27:17896254. https://doi.org/10.1080/01443610701469636
doi: 10.1080/01443610701469636
Lilja M, Palva T, Ramsay H, Laitinen K, Andersson S (2006) Meconium contaminated amniotic fluid and infant otitis media. Is it a risk factor in children surviving aspiration and initial distress of respiration? Int J Pediatr Otorhinolaryngol 70:655–662. https://doi.org/10.1016/j.ijporl.2005.08.019
doi: 10.1016/j.ijporl.2005.08.019
pubmed: 16188327
Vázquez Nava F, Salas Ramírez E, Sánchez Núncio HR, Saldivar González AH, Beltrán Saldaña J, Cadena Mata D, Pérez Rodŕiguez P, Pérez Martin J, Almeida VM, Guidos Fogelbach G (2006) Meconium aspiration syndrome, parental atopy and asthma symptoms in children under two years old. Rev Alerg Mex 53:130–135
pubmed: 17137188
Gupta AK, Anand NK (1991) Wheezy baby syndrome—a possible sequelae of neonatal meconium aspiration syndrome. Indian J Pediatr 58:525–527. https://doi.org/10.1007/BF02750935
doi: 10.1007/BF02750935
pubmed: 1800335
Djemal N, Ben Ammar H, Masmoudi K, Rguaieg R, Trigui L, Ben Hmad A, Kannou M, Hmida N, Gargouri A, Zouari N, Rekik A (2008) Fonction respiratoire des enfants ayant des antécédents d’inhalation méconiale [Pulmonary function in children after neonatal meconium aspiration syndrome]. Arch Pediatr 15:105–110. https://doi.org/10.1016/j.arcped.2007.10.026
doi: 10.1016/j.arcped.2007.10.026
pubmed: 18207713
Matalon R, Wainstock T, Walfisch A, Sheiner E (2021) Exposure to meconium-stained amniotic fluid and long-term neurological-related hospitalizations throughout childhood. Am J Perinatol 38:1513–1518. https://doi.org/10.1055/s-0040-1713863
doi: 10.1055/s-0040-1713863
pubmed: 32620023
Krieger Y, Horev A, Wainstock T, Sheiner E, Walfisch A (2020) Meconium-stained amniotic fluid as a protective factor against childhood dermatitis and skin rash-related hospitalization in the offspring - a population-based cohort analysis. J Eur Acad Dermatol Venereol 34:319–324. https://doi.org/10.1111/jdv.15881
doi: 10.1111/jdv.15881
pubmed: 31419350
Strina A, Barreto ML, Cooper PJ, Rodrigues LC (2014) Risk factors for non-atopic asthma/wheeze in children and adolescents: a systematic review. Emerg Themes Epidemiol. https://doi.org/10.1186/1742-7622-11-5
doi: 10.1186/1742-7622-11-5
pubmed: 24963333
pmcid: 4068161
Kawamoto T, Nitta H, Murata K, Toda E, Tsukamoto N, Hasegawa M, Yamagata Z, Kayama F, Kishi R, Ohya Y, Saito H, Sago H, Okuyama M, Ogata T, Yokoya S, Koresawa Y, Shibata Y, Nakayama S, Michikawa T, Takeuchi A, Satoh H, Working Group of the Epidemiological Research for Children’s Environmental Health (2014) Rationale and study design of the Japan environment and children’s study (JECS). BMC Public Health 14:25. https://doi.org/10.1186/1471-2458-14-25
doi: 10.1186/1471-2458-14-25
pubmed: 24410977
pmcid: 3893509
Michikawa T, Nitta H, Nakayama SF, Yamazaki S, Isobe T, Tamura K, Suda E, Ono M, Yonemoto J, Iwai-Shimada M, Kobayashi Y, Suzuki G, Kawamoto T, Japan Environment and Children’s Study (JECS) (2018) Baseline profile of participants in the Japan Environment and Children’s Study (JECS). J Epidemiol 28:99–104. https://doi.org/10.2188/jea.JE20170018
doi: 10.2188/jea.JE20170018
pubmed: 29093304
pmcid: 5792233
Asher MI, Keil U, Anderson HR, Beasley R, Crane J, Martinez F, Mitchell EA, Pearce N, Sibbald B, Stewart AW et al (1995) International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. Eur Respir J 8:483–491. https://doi.org/10.1183/09031936.95.08030483
doi: 10.1183/09031936.95.08030483
pubmed: 7789502
Weiland SK, Björkstén B, Brunekreef B, Cookson WO, Mutius E, Strachan DP (2004) The international study of asthma and allergies in childhood phase II study group. Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods. Eur Respir J 24:406–412. https://doi.org/10.1183/09031936.04.00090303
doi: 10.1183/09031936.04.00090303
pubmed: 15358699
Ellwood P, Asher MI, Beasley R, Clayton TO, Stewart AW, Committee ISAACS (2005) The International Study of Asthma and Allergies in Childhood (ISAAC): phase Three rationale and methods. Int J Tuberc Lung Dis 9:15675544
Kyozuka H, Fujimori K, Hosoya M, Yasumura S, Yokoyama T, Sato A, Hashimoto K, Japan Environment and Children’s Study (JECS) Group (2019) The effect of maternal age at the first childbirth on gestational age and birth weight: the Japan Environment and Children’s Study (JECS). J Epidemiol 29:187–191. https://doi.org/10.2188/jea.JE20170283
doi: 10.2188/jea.JE20170283
pubmed: 30078812
pmcid: 6445800
Murata T, Kyozuka H, Yamaguchi A, Fukuda T, Yasuda S, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K, Japan Environment and Children’s Study (JECS) Group (2021) Maternal pre-pregnancy body mass index and foetal acidosis in vaginal and caesarean deliveries: the Japan Environment and Children’s Study. Sci Rep 11(11):4350. https://doi.org/10.1038/s41598-020-79178-1
doi: 10.1038/s41598-020-79178-1
pubmed: 33623113
pmcid: 7902605
Murata T, Kyozuka H, Yasuda S, Fukuda T, Yamaguchi A, Maeda H, Sato A, Ogata Y, Shinoki K, Hosoya M, Yasumura S, Hashimoto K, Nishigori H, Fujimori K, Japan Environment, Children’s Study (JECS) Group (2021) Association between maternal ritodrine hydrochloride administration during pregnancy and childhood wheezing up to three years of age: The Japan environment and children’s study. Pediatr Allergy Immunol 32:1455–1463. https://doi.org/10.1111/pai.13545
doi: 10.1111/pai.13545
pubmed: 34013624
Baumfeld Y, Walfisch A, Wainstock T, Segal I, Sergienko R, Landau D, Sheiner E (2018) Elective cesarean delivery at term and the long-term risk for respiratory morbidity of the offspring. Eur J Pediatr 177:1653–1659. https://doi.org/10.1007/s00431-018-3225-8
doi: 10.1007/s00431-018-3225-8
pubmed: 30091110
Mikolka P, Kopincova J, Tomcikova Mikusiakova L, Kosutova P, Antosova M, Calkovska A, Mokra D (2016) Effects of surfactant/budesonide therapy on oxidative modifications in the lung in experimental meconium-induced lung injury. J Physiol Pharmacol 67:57–65
pubmed: 27010895
Grommes J, Soehnlein O (2011) Contribution of neutrophils to acute lung injury. Mol Med 17:293–307. https://doi.org/10.2119/molmed.2010.00138
doi: 10.2119/molmed.2010.00138
pubmed: 21046059
Williams AE, Chambers RC (2014) The mercurial nature of neutrophils: still an enigma in ARDS? Am J Physiol Lung Cell Mol Physiol 306:L217–L230. https://doi.org/10.1152/ajplung.00311.2013
doi: 10.1152/ajplung.00311.2013
pubmed: 24318116
Hooper LV, Littman DR, Macpherson AJ (2012) Interactions between the microbiota and the immune system. Science 336:22674334. https://doi.org/10.1126/science.1223490
doi: 10.1126/science.1223490
Longman RS, Littman DR (2015) The functional impact of the intestinal microbiome on mucosal immunity and systemic autoimmunity. Curr Opin Rheumatol 27:381–387. https://doi.org/10.1097/BOR.0000000000000190
doi: 10.1097/BOR.0000000000000190
pubmed: 26002030
pmcid: 4929006
Penders J, Stobberingh EE, Brandt PA, Thijs C (2007) The role of the intestinal microbiota in the development of atopic disorders. Allergy 62:1223–1236. https://doi.org/10.1111/j.1398-9995.2007.01462.x
doi: 10.1111/j.1398-9995.2007.01462.x
pubmed: 17711557
West CE (2014) Gut microbiota and allergic disease: new findings. Curr Opin Clin Nutr Metab Care 17:261–266. https://doi.org/10.1097/MCO.0000000000000044
doi: 10.1097/MCO.0000000000000044
pubmed: 24535216
Azad MB, Konya T, Guttman DS, Field CJ, Sears MR, HayGlass KT, Mandhane PJ, Turvey SE, Subbarao P, Becker AB, Scott JA, Kozyrskyj AL, Investigators CHILDS (2015) Infant gut microbiota and food sensitization: associations in the first year of life. Clin Exp Allergy 45:632–643. https://doi.org/10.1111/cea.12487
doi: 10.1111/cea.12487
pubmed: 25599982
Jiménez E, Marín ML, Martín R, Odriozola JM, Olivares M, Xaus J, Fernández L, Rodríguez JM (2008) Is meconium from healthy newborns actually sterile? Res Microbiol 159:187–193. https://doi.org/10.1016/j.resmic.2007.12.007
doi: 10.1016/j.resmic.2007.12.007
pubmed: 18281199
Collado MC, Rautava S, Aakko J, Isolauri E, Salminen S (2016) Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid. Sci Rep 6:27001291. https://doi.org/10.1038/srep23129
doi: 10.1038/srep23129
Walker RW, Clemente JC, Peter I, Loos RJF (2017) The prenatal gut microbiome: are we colonized with bacteria in utero? Pediatr Obes 1:3–17. https://doi.org/10.1111/ijpo.12217
doi: 10.1111/ijpo.12217
Damm JA, Smith B, Greisen G, Krogfelt KA, Clausen ML, Agner T (2017) The influence of probiotics for preterm neonates on the incidence of atopic dermatitis-results from a historically controlled cohort study. Arch Dermatol Res 309:259–264. https://doi.org/10.1007/s00403-017-1725-4
doi: 10.1007/s00403-017-1725-4
pubmed: 28271213
Reddel HK, Bateman ED, Becker A, Boulet LP, Cruz AA, Drazen JM, Haahtela T, Hurd SS, Inoue H, Jongste JC, Lemanske RF, Levy ML, O’Byrne PM, Paggiaro P, Pedersen SE, Pizzichini E, Soto-Quiroz M, Szefler SJ, Wong GW, FitzGerald JM (2015) A summary of the new GINA strategy: a roadmap to asthma control. Eur Respir J 46:622–639. https://doi.org/10.1183/13993003.00853-2015
doi: 10.1183/13993003.00853-2015
pubmed: 26206872
pmcid: 4554554
Lebold KM, Jacoby DB, Drake MG (2020) Inflammatory mechanisms linking maternal and childhood asthma. J Leukoc Biol 108:113–121. https://doi.org/10.1002/JLB.3MR1219-338R
doi: 10.1002/JLB.3MR1219-338R
pubmed: 32040236
Black M, Bhattacharya S, Philip S, Norman JE, McLernon DJ (2015) Planned cesarean delivery at term and adverse outcomes in childhood health. JAMA 314:2271–2279. https://doi.org/10.1001/jama.2015.16176
doi: 10.1001/jama.2015.16176
pubmed: 26624826
pmcid: 5055095
Rutayisire E, Huang K, Liu Y, Tao F (2016) The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants’ life: a systematic review. BMC Gastroenterol 16:86. https://doi.org/10.1186/s12876-016-0498-0
doi: 10.1186/s12876-016-0498-0
pubmed: 27475754
pmcid: 4967522