COVID-19 Infections in Gonads: Consequences on Fertility?
Journal
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme
ISSN: 1439-4286
Titre abrégé: Horm Metab Res
Pays: Germany
ID NLM: 0177722
Informations de publication
Date de publication:
Aug 2022
Aug 2022
Historique:
pubmed:
20
7
2022
medline:
12
8
2022
entrez:
19
7
2022
Statut:
ppublish
Résumé
COVID-19 may influence human fertility and sexuality in several ways. Different cell types in gonads show a constitutive expression of angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine subtype 2 (TMPRSS2), which provide potential entry pathways for SARS-CoV-2. In addition to the biological effects of a COVID-19 infection on the gonads, the impact of the ongoing COVID-19 pandemic on mental health issues and sexual behavior may affect reproduction. This review summarizes the current knowledge on the influence of COVID-19 on the gonads and discusses possible consequences on human fertility. In this context, the close interaction between the hypothalamic-pituitary-adrenal axis and the hypothalamic-pituitary-gonadal axis in response to COVID-19-related stress is discussed. Some women noticed changes in their menstrual cycle during the COVID-19 pandemic, which could be due to psychological stress, for example. In addition, occasional cases of reduced oocyte quality and ovarian function are described after COVID-19 infection. In men, COVID-19 may cause a short-term decrease in fertility by damaging testicular tissue and/or impairing spermatogenesis. Moreover, decreased ratio testosterone/LH and FSH/LH in COVID-19 compared to aged-matched healthy men has been reported. Available data do not suggest any effect of the available SARS-CoV-2 vaccines on fertility. The effects of long COVID on human fertility have been reported and include cases with premature ovarian failure and oligomenorrhoea in women and erectile dysfunction in men. Despite the increasing knowledge about the effects of COVID-19 infections on human gonads and fertility, the long-term consequences of the COVID-19 pandemic cannot yet be assessed in this context.
Identifiants
pubmed: 35853464
doi: 10.1055/a-1891-6621
pmc: PMC9363149
doi:
Substances chimiques
COVID-19 Vaccines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
549-555Informations de copyright
The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).
Déclaration de conflit d'intérêts
The authors declare that they have no conflict of interest.
Références
J Med Virol. 2021 Jan;93(1):456-462
pubmed: 32621617
Eur J Clin Microbiol Infect Dis. 2021 Jul;40(7):1559-1567
pubmed: 33555444
Nat Commun. 2021 Feb 10;12(1):915
pubmed: 33568665
Front Endocrinol (Lausanne). 2021 Mar 22;12:642755
pubmed: 33841334
Biol Reprod. 2006 Feb;74(2):410-6
pubmed: 16237152
Sci Rep. 2019 Oct 21;9(1):15052
pubmed: 31636313
BMC Med. 2020 Jul 15;18(1):220
pubmed: 32664957
Cancer Res. 1999 Sep 1;59(17):4180-4
pubmed: 10485450
Int J Gynaecol Obstet. 2021 Jul;154(1):179-180
pubmed: 33896002
Cell Mol Immunol. 2021 Feb;18(2):487-489
pubmed: 33318629
Am J Epidemiol. 2022 Jul 23;191(8):1383-1395
pubmed: 35051292
Cell Res. 2021 Aug;31(8):836-846
pubmed: 34135479
Obstet Gynecol. 2022 Apr 1;139(4):481-489
pubmed: 34991109
N Engl J Med. 2015 Dec 17;373(25):2448-54
pubmed: 26465384
Sex Med Rev. 2022 Apr;10(2):271-285
pubmed: 34933829
Reproduction. 2021 Mar;161(3):319-331
pubmed: 33522983
Biochem Pharmacol. 2021 Jun;188:114517
pubmed: 33722535
Eur J Endocrinol. 2021 May;184(5):637-645
pubmed: 33635829
Eur J Clin Microbiol Infect Dis. 2021 Feb;40(2):451-455
pubmed: 33245471
Fertil Steril. 2001 Feb;75(2):237-48
pubmed: 11172821
Cells. 2020 Apr 09;9(4):
pubmed: 32283711
Prehosp Disaster Med. 2020 Dec;35(6):688-689
pubmed: 32959752
Spermatogenesis. 2015 Jan 26;4(2):e996025
pubmed: 26413400
Mol Psychiatry. 2022 Jan;27(1):34-37
pubmed: 34140635
Cell. 2021 Feb 4;184(3):775-791.e14
pubmed: 33503446
Stress. 2017 Sep;20(5):476-494
pubmed: 28859530
Clin Sci (Lond). 2020 Nov 27;134(22):2929-2941
pubmed: 33196086
Cell Rep. 2020 Sep 22;32(12):108175
pubmed: 32946807
Front Med (Lausanne). 2022 Feb 09;9:778489
pubmed: 35223894
Int J Gynaecol Obstet. 2020 Jul;150(1):98-102
pubmed: 32392400
iScience. 2023 Apr 21;26(4):106401
pubmed: 36987520
Reprod Biol Endocrinol. 2021 May 13;19(1):69
pubmed: 33985514
J Endocrinol Invest. 2021 Dec;44(12):2675-2684
pubmed: 33929709
Fertil Steril. 2022 Feb;117(2):287-296
pubmed: 34937665
Lancet. 2021 Jan 16;397(10270):220-232
pubmed: 33428867
Minerva Endocrinol. 2010 Jun;35(2):109-25
pubmed: 20595939
Nat Rev Dis Primers. 2016 Aug 11;2:16057
pubmed: 27510637
World J Mens Health. 2021 Jan;39(1):65-74
pubmed: 33151050
Genomics. 2021 Nov;113(6):3449-3460
pubmed: 34418496
Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):603-614
pubmed: 31773182
JAMA. 2021 Jul 20;326(3):273-274
pubmed: 34137808
BMC Infect Dis. 2021 Apr 10;21(1):337
pubmed: 33838657
Fertil Steril. 2007 Oct;88(4):970.e1-7
pubmed: 17434502
Hum Reprod. 2021 Aug 18;36(9):2506-2513
pubmed: 34364311
PLoS Med. 2018 Jul 24;15(7):e1002611
pubmed: 30040845
Folia Histochem Cytobiol. 2001;39(2):173-4
pubmed: 11374811
Nat Rev Immunol. 2021 Apr;21(4):200-201
pubmed: 33658707
Reprod Toxicol. 2021 Aug;103:28-35
pubmed: 34058573
Science. 2020 Jul 24;369(6502):370-371
pubmed: 32703862
Reprod Sci. 2009 Mar;16(3):247-56
pubmed: 19164480
Ann Rheum Dis. 2015 Nov;74(11):1968-75
pubmed: 24919467
World J Mens Health. 2021 Jul;39(3):466-469
pubmed: 33988001
Lancet Diabetes Endocrinol. 2022 Mar;10(3):221-230
pubmed: 35114136
Sci China Life Sci. 2020 Jul;63(7):1006-1015
pubmed: 32361911
Front Med (Lausanne). 2021 Mar 19;8:635255
pubmed: 33816526
EClinicalMedicine. 2021 Aug;38:101013
pubmed: 34250457
EClinicalMedicine. 2020 Nov;28:100604
pubmed: 33134901
Nat Rev Urol. 2022 Feb;19(2):116-127
pubmed: 34837081
Am J Reprod Immunol. 2017 Apr;77(4):
pubmed: 28120470
Biol Reprod. 2020 Aug 21;103(3):449-451
pubmed: 32427288
Cell Mol Immunol. 2014 Sep;11(5):428-37
pubmed: 24954222
EClinicalMedicine. 2020 Dec;29:100670
pubmed: 33283179
J Endocrinol Invest. 2021 Jul;44(7):1379-1386
pubmed: 33512688
Sex Med. 2021 Oct;9(5):100408
pubmed: 34333225
Front Cell Dev Biol. 2020 Aug 19;8:783
pubmed: 32974340
Am J Physiol Regul Integr Comp Physiol. 2008 Dec;295(6):R1953-61
pubmed: 18945956
PLoS One. 2021 May 20;16(5):e0251916
pubmed: 34015003
Am Fam Physician. 2000 Aug 15;62(4):782-6
pubmed: 10969857
Nat Rev Mol Cell Biol. 2022 Jan;23(1):3-20
pubmed: 34611326
Int J Mol Sci. 2013 Oct 21;14(10):21071-86
pubmed: 24152441
Reprod Biomed Online. 2022 Apr;44(4):685-688
pubmed: 35279377
Andrology. 2022 Jan;10(1):13-23
pubmed: 34196475
Andrology. 2021 Jan;9(1):23-26
pubmed: 32453494
Sex Med. 2021 Aug;9(4):100367
pubmed: 34146832
JAMA Netw Open. 2020 May 1;3(5):e208292
pubmed: 32379329
Infect Dis Poverty. 2020 Apr 28;9(1):45
pubmed: 32345362