Conjoint analysis of OPRPN and SMR3A protein expression as potential predictive biomarkers for head and neck squamous cell carcinoma after radiotherapy.

Androgens Biomarkers, Tumor / metabolism Carcinoma, Squamous Cell / genetics Cohort Studies Head and Neck Neoplasms / genetics Humans Prognosis Retrospective Studies Squamous Cell Carcinoma of Head and Neck / radiotherapy Submandibular Gland / chemistry
OPRPN fractionated IR head and neck squamous cell carcinoma opiorphin gene family prognostic biomarker radioresistance submaxillary gland androgen‑regulated protein 3A tissue microarray

Journal

Oncology reports
ISSN: 1791-2431
Titre abrégé: Oncol Rep
Pays: Greece
ID NLM: 9422756

Informations de publication

Date de publication:
Sep 2022
Historique:
received: 25 01 2022
accepted: 26 05 2022
entrez: 20 7 2022
pubmed: 21 7 2022
medline: 22 7 2022
Statut: ppublish

Résumé

Increased submaxillary gland androgen‑regulated protein 3A (SMR3A) expression was previously shown to serve as an independent risk factor for oropharyngeal squamous cell carcinoma (OPSCC) and as a surrogate biomarker for active estrogen receptor 2 signaling in radioresistant tumor cells. In the present study, it was aimed to unravel the expression and clinical significance of another member of the opiorphin family, opiorphin prepropeptide (OPRPN), in the radiotherapy for head and neck squamous cell carcinoma (HNSCC). Expression of SMR3A and OPRPN were analyzed for the prior and post fractionated irradiation (4x2 Gy) by double immunofluorescence staining in established HNSCC cell lines as well as by immunohistochemical (IHC) staining in

Identifiants

DOI: 10.3892/or.2022.8374 PMID: 35856431
pubmed: 35856431
doi: 10.3892/or.2022.8374
pii: 159
doi:
pii:

Substances chimiques

Androgens 0
Biomarkers, Tumor 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Chao Rong (C)

Department of Pathology, School of Biology and Basic Medical Sciences, Suzhou Medical College of Soochow University, Suzhou 215123, P.R. China.

Jennifer Grünow (J)

Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Julia Thierauf (J)

Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Carlota Lucena-Porcel (C)

Institute of Pathology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Gerald Major (G)

Department of Radiation Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Dana Holzinger (D)

Molecular Diagnostics of Oncogenic Infections, German Cancer Research Center (DKFZ), D‑69120 Heidelberg, Germany.

Gerhard Dyckhoff (G)

Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Johann Kern (J)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim of Heidelberg University, D‑68167 Mannheim, Germany.

Anne Lammert (A)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim of Heidelberg University, D‑68167 Mannheim, Germany.

Claudia Scherl (C)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim of Heidelberg University, D‑68167 Mannheim, Germany.

Nicole Rotter (N)

Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Mannheim, Medical Faculty Mannheim of Heidelberg University, D‑68167 Mannheim, Germany.

Peter K Plinkert (PK)

Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

Annette Affolter (A)

Department of Otorhinolaryngology, Head and Neck Surgery, Experimental Head and Neck Oncology, Heidelberg University Hospital, D‑69120 Heidelberg, Germany.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs épidermoïdes › Carcinome épidermoïde › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Diagnostic › Pronostic › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Tumeurs › Tumeurs par siège › Tumeurs de la tête et du cou › Carcinome épidermoïde de la tête et du cou › Conjoint analysis of OPRPN and SMR3A protein...
questionsmedicales.fr › Système stomatognathique › Bouche › Glandes salivaires › Glande submandibulaire › Conjoint analysis of OPRPN and SMR3A protein...