Lack of COL6/collagen VI causes megakaryocyte dysfunction by impairing autophagy and inducing apoptosis.
Apoptosis
autophagy
collagen VI
endoplasmic reticulum stress
megakaryocytes
rapamycin
unfolded protein response
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
03 2023
03 2023
Historique:
pubmed:
21
7
2022
medline:
3
3
2023
entrez:
20
7
2022
Statut:
ppublish
Résumé
Endoplasmic reticulum stress is an emerging significant player in the molecular pathology of connective tissue disorders. In response to endoplasmic reticulum stress, cells can upregulate macroautophagy/autophagy, a fundamental cellular homeostatic process used by cells to degrade and recycle proteins or remove damaged organelles. In these scenarios, autophagy activation can support cell survival. Here we demonstrated by
Identifiants
pubmed: 35857791
doi: 10.1080/15548627.2022.2100105
pmc: PMC9980446
doi:
Substances chimiques
Phosphatidylinositol 3-Kinases
EC 2.7.1.-
Collagen Type VI
0
Apoptosis Regulatory Proteins
0
Endoplasmic Reticulum Chaperone BiP
0
Proto-Oncogene Proteins c-bcl-2
0
Sirolimus
W36ZG6FT64
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
984-999Références
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